Search Results - "KAGAN, E"

Drug repurposing from the perspective of pharmaceutical companies by Cha, Y, Erez, T, Reynolds, I J, Kumar, D, Ross, J, Koytiger, G, Kusko, R, Zeskind, B, Risso, S, Kagan, E, Papapetropoulos, S, Grossman, I, Laifenfeld, D

“…Drug repurposing holds the potential to bring medications with known safety profiles to new patient populations. Numerous examples exist for the identification…”
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Regulation of lipid peroxidation and ferroptosis in diverse species by Conrad, Marcus, Kagan, Valerian E, Bayir, Hülya, Pagnussat, Gabriela C, Head, Brian, Traber, Maret G, Stockwell, Brent R

“…Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin…”
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Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury by Kenny, Elizabeth M., Fidan, Emin, Yang, Qin, Anthonymuthu, Tamil S., New, Lee Ann, Meyer, Elizabeth A., Wang, Hong, Kochanek, Patrick M., Dixon, C. Edward, Kagan, Valerian E., Bayir, Hülya

“…OBJECTIVES:Traumatic brain injury triggers multiple cell death pathways, possibly including ferroptosis—a recently described cell death pathway that results…”
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Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis by Bayır, Hülya, Anthonymuthu, Tamil S, Tyurina, Yulia Y, Patel, Sarju J, Amoscato, Andrew A, Lamade, Andrew M, Yang, Qin, Vladimirov, Georgy K, Philpott, Caroline C, Kagan, Valerian E

“…Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions leading to neuronal death, including programs of regulated death, are…”
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Fatty acid transport protein 2 reprograms neutrophils in cancer by Veglia, Filippo, Tyurin, Vladimir A., Blasi, Maria, De Leo, Alessandra, Kossenkov, Andrew V., Donthireddy, Laxminarasimha, To, Tsun Ki Jerrick, Schug, Zach, Basu, Subhasree, Wang, Fang, Ricciotti, Emanuela, DiRusso, Concetta, Murphy, Maureen E., Vonderheide, Robert H., Lieberman, Paul M., Mulligan, Charles, Nam, Brian, Hockstein, Neil, Masters, Gregory, Guarino, Michael, Lin, Cindy, Nefedova, Yulia, Black, Paul, Kagan, Valerian E., Gabrilovich, Dmitry I.

“…Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses…”
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis by Kagan, Valerian E, Mao, Gaowei, Qu, Feng, Angeli, Jose Pedro Friedmann, Doll, Sebastian, Croix, Claudette St, Dar, Haider Hussain, Liu, Bing, Tyurin, Vladimir A, Ritov, Vladimir B, Kapralov, Alexandr A, Amoscato, Andrew A, Jiang, Jianfei, Anthonymuthu, Tamil, Mohammadyani, Dariush, Yang, Qin, Proneth, Bettina, Klein-Seetharaman, Judith, Watkins, Simon, Bahar, Ivet, Greenberger, Joel, Mallampalli, Rama K, Stockwell, Brent R, Tyurina, Yulia Y, Conrad, Marcus, Bayır, Hülya

“…Arachidonyl and adrenoyl PE phospholipids generated by ACSL4, an acyl-CoA synthase, are doubly or triply oxidized by lipoxygenases and other iron-containing…”
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Necroptotic cell death in anti‐cancer therapy by Krysko, Olga, Aaes, Tania Løve, Kagan, Valerian E., D'Herde, Katharina, Bachert, Claus, Leybaert, Luc, Vandenabeele, Peter, Krysko, Dmitri V.

“…Summary Necroptosis is one the best‐characterized forms of regulated necrosis. Necroptosis is mediated by the kinase activities of receptor interacting protein…”
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease by Stockwell, Brent R., Friedmann Angeli, José Pedro, Bayir, Hülya, Bush, Ashley I., Conrad, Marcus, Dixon, Scott J., Fulda, Simone, Gascón, Sergio, Hatzios, Stavroula K., Kagan, Valerian E., Noel, Kay, Jiang, Xuejun, Linkermann, Andreas, Murphy, Maureen E., Overholtzer, Michael, Oyagi, Atsushi, Pagnussat, Gabriela C., Park, Jason, Ran, Qitao, Rosenfeld, Craig S., Salnikow, Konstantin, Tang, Daolin, Torti, Frank M., Torti, Suzy V., Toyokuni, Shinya, Woerpel, K.A., Zhang, Donna D.

“…Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence…”
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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma by Hassannia, Behrouz, Wiernicki, Bartosz, Ingold, Irina, Qu, Feng, Van Herck, Simon, Tyurina, Yulia Y, Bayır, Hülya, Abhari, Behnaz A, Angeli, Jose Pedro Friedmann, Choi, Sze Men, Meul, Eline, Heyninck, Karen, Declerck, Ken, Chirumamilla, Chandra Sekhar, Lahtela-Kakkonen, Maija, Van Camp, Guy, Krysko, Dmitri V, Ekert, Paul G, Fulda, Simone, De Geest, Bruno G, Conrad, Marcus, Kagan, Valerian E, Vanden Berghe, Wim, Vandenabeele, Peter, Vanden Berghe, Tom

“…High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural…”
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Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis by Wiernicki, Bartosz, Dubois, Hanne, Tyurina, Yulia Y., Hassannia, Behrouz, Bayir, Hülya, Kagan, Valerian E., Vandenabeele, Peter, Wullaert, Andy, Vanden Berghe, Tom

“…Lipid peroxidation (LPO) drives ferroptosis execution. However, LPO has been shown to contribute also to other modes of regulated cell death (RCD). To clarify…”
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Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation by Li, Wenjun, Feng, Guoshuai, Gauthier, Jason M, Lokshina, Inessa, Higashikubo, Ryuji, Evans, Sarah, Liu, Xinping, Hassan, Adil, Tanaka, Satona, Cicka, Markus, Hsiao, Hsi-Min, Ruiz-Perez, Daniel, Bredemeyer, Andrea, Gross, Richard W, Mann, Douglas L, Tyurina, Yulia Y, Gelman, Andrew E, Kagan, Valerian E, Linkermann, Andreas, Lavine, Kory J, Kreisel, Daniel

“…Non-apoptotic forms of cell death can trigger sterile inflammation through the release of danger-associated molecular patterns, which are recognized by innate…”
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Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress by Shvedova, Anna A., Pietroiusti, Antonio, Fadeel, Bengt, Kagan, Valerian E.

“…Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also…”
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Long-term glycaemic improvement with the initiation of an automated insulin delivery system in insulin pump-naïve older adults with type 1 diabetes by Karakus, Kagan E, Mason, Emma, Akturk, Halis K

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Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1 by Beatty, Alexander, Singh, Tanu, Tyurina, Yulia Y., Tyurin, Vladimir A., Samovich, Svetlana, Nicolas, Emmanuelle, Maslar, Kristen, Zhou, Yan, Cai, Kathy Q., Tan, Yinfei, Doll, Sebastian, Conrad, Marcus, Subramanian, Aravind, Bayır, Hülya, Kagan, Valerian E., Rennefahrt, Ulrike, Peterson, Jeffrey R.

“…Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione…”
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Tirzepatide-Induced Rapid Weight Loss-Related Thyrotoxicosis by Karakus, Kagan E, Shah, Viral N, Akturk, Halis K

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Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis by Protchenko, Olga, Baratz, Ethan, Jadhav, Shyamalagauri, Li, Fengmin, Shakoury‐Elizeh, Minoo, Gavrilova, Oksana, Ghosh, Manik C., Cox, James E., Maschek, J. Alan, Tyurin, Vladimir A., Tyurina, Yulia Y., Bayir, Hülya, Aron, Allegra T., Chang, Christopher J., Kagan, Valerian E., Philpott, Caroline C.

“…Background and Aims Iron is essential yet also highly chemically reactive and potentially toxic. The mechanisms that allow cells to use iron safely are not…”
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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation by Gaschler, Michael M., Andia, Alexander A., Liu, Hengrui, Csuka, Joleen M., Hurlocker, Brisa, Vaiana, Christopher A., Heindel, Daniel W., Zuckerman, Dylan S., Bos, Pieter H., Reznik, Eduard, Ye, Ling F., Tyurina, Yulia Y., Lin, Annie J., Shchepinov, Mikhail S., Chan, Amy Y., Peguero-Pereira, Eveliz, Fomich, Maksim A., Daniels, Jacob. D., Bekish, Andrei V., Shmanai, Vadim V., Kagan, Valerian E., Mahal, Lara K., Woerpel, K. A., Stockwell, Brent R.

“…Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO 2 is an…”
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PLA2G6 guards placental trophoblasts against ferroptotic injury by Beharier, Ofer, Tyurin, Vladimir A., Goff, Julie P., Guerrero-Santoro, Jennifer, Kajiwara, Kazuhiro, Chu, Tianjiao, Tyurina, Yulia Y., St Croix, Claudette M., Wallace, Callen T., Parry, Samuel, Parks, W. Tony, Kagan, Valerian E., Sadovsky, Yoel

“…The recently identified ferroptotic cell death is characterized by excessive accumulation of hydroperoxy-arachidonoyl (C20:4)- or adrenoyl (C22:4)-…”
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Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney by Bayır, Hülya, Dixon, Scott J., Tyurina, Yulia Y., Kellum, John A., Kagan, Valerian E.

“…Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can be…”
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Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer by Veglia, Filippo, Tyurin, Vladimir A., Mohammadyani, Dariush, Blasi, Maria, Duperret, Elizabeth K., Donthireddy, Laxminarasimha, Hashimoto, Ayumi, Kapralov, Alexandr, Amoscato, Andrew, Angelini, Roberto, Patel, Sima, Alicea-Torres, Kevin, Weiner, David, Murphy, Maureen E., Klein-Seetharaman, Judith, Celis, Esteban, Kagan, Valerian E., Gabrilovich, Dmitry I.

“…Cross-presentation is a critical function of dendritic cells (DCs) required for induction of antitumor immune responses and success of cancer immunotherapy. It…”
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