Search Results - "KAFATOS, Fotis C"

Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites by Meister, Stephan, Agianian, Bogos, Turlure, Fanny, Relógio, Angela, Morlais, Isabelle, Kafatos, Fotis C, Christophides, George K

“…Recognition of peptidoglycan (PGN) is paramount for insect antibacterial defenses. In the fruit fly Drosophila melanogaster, the transmembrane PGN Recognition…”
Get full text

Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes by Waterhouse, Robert M, Kriventseva, Evgenia V, Meister, Stephan, Xi, Zhiyong, Alvarez, Kanwal S, Bartholomay, Lyric C, Barillas-Mury, Carolina, Bian, Guowu, Blandin, Stephanie, Christensen, Bruce M, Dong, Yuemei, Jiang, Haobo, Kanost, Michael R, Koutsos, Anastasios C, Levashina, Elena A, Li, Jianyong, Ligoxygakis, Petros, MacCallum, Robert M, Mayhew, George F, Mendes, Antonio, Michel, Kristin, Osta, Mike A, Paskewitz, Susan, Shin, Sang Woon, Vlachou, Dina, Wang, Lihui, Wei, Weiqi, Zheng, Liangbiao, Zou, Zhen, Severson, David W, Raikhel, Alexander S, Kafatos, Fotis C, Dimopoulos, George, Zdobnov, Evgeny M, Christophides, George K

“…Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and…”
Get full text

Functional Genomic Analysis of Midgut Epithelial Responses in Anopheles during Plasmodium Invasion by Vlachou, Dina, Schlegelmilch, Timm, Christophides, George K., Kafatos, Fotis C.

“…Background: The malaria parasite Plasmodium must complete a complex developmental life cycle within Anopheles mosquitoes before it can be transmitted into the…”
Get full text

Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae by Christophides, George K., Vlachou, Dina, Kafatos, Fotis C.

“…In much of Africa, the mosquito Anopheles gambiae is the major vector of human malaria, a devastating infectious disease caused by Plasmodium parasites. Vector…”
Get full text

Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae by Pinto, Sofia B, Lombardo, Fabrizio, Koutsos, Anastasios C, Waterhouse, Robert M, McKay, Krista, An, Chunju, Ramakrishnan, Chandra, Kafatos, Fotis C, Michel, Kristin

“…Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation and also secrete immune factors such as opsonins,…”
Get full text

Two C-type Lectins Cooperate to Defend Anopheles gambiae against Gram-negative Bacteria by Schnitger, Anna K.D., Yassine, Hassan, Kafatos, Fotis C., Osta, Mike A.

“…C-type lectins (CTLs) are a family of proteins that share a common structural motif, the carbohydrate recognition domain, and may act as receptors in pathogen…”
Get full text

Comprehensive genetic dissection of the hemocyte immune response in the malaria mosquito Anopheles gambiae by Lombardo, Fabrizio, Ghani, Yasmeen, Kafatos, Fotis C, Christophides, George K

“…Reverse genetics in the mosquito Anopheles gambiae by RNAi mediated gene silencing has led in recent years to an advanced understanding of the mosquito immune…”
Get full text

Phylogenetic Perspectives in Innate Immunity by Hoffmann, Jules A., Kafatos, Fotis C., Janeway, Charles A., Ezekowitz, R. A. B.

“…The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent…”
Get full text

Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae by Meister, S, Kanzok, S.M, Zheng, X.I, Luna, C, Li, T.R, Hoa, N.T, Clayton, J.R, White, K.P, Kafatos, F.C, Christophides, G.K

“…We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-kappaB-like transcription factor orthologous to…”
Get full text

role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae by Kumar, S, Christophides, G.K, Cantera, R, Charles, B, Han, Y.S, Meister, S, Dimopoulos, G, Kafatos, F.C, Barillas-Mury, C

“…Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected…”
Get full text

The Melanization Reaction Is Not Required for Survival of Anopheles gambiae Mosquitoes after Bacterial Infections by Schnitger, Anna K.D., Kafatos, Fotis C., Osta, Mike A.

“…The melanization reaction of insects requires activation of pro-phenoloxidase by a proteolytic cascade leading to melanin production. Studies in adult…”
Get full text

Infection Intensity-Dependent Responses of Anopheles gambiae to the African Malaria Parasite Plasmodium falciparum by MENDES, Antonio M, AWONO-AMBENE, Parfait H, NSANGO, Sandrine E, COHUET, Anna, FONTENILLE, Didier, KAFATOS, Fotis C, CHRISTOPHIDES, George K, MORLAIS, Isabelle, VLACHOU, Dina

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites by Abraham, E.G, Pinto, S.B, Ghosh, A, Vanlandingham, D.L, Budd, A, Higgs, S, Kafatos, F.C, Jacobs-Lorena, M, Michel, K

“…We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi and Anopheles gambiae using phylogenetic, molecular, reverse genetic, and…”
Get full text

Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa by Mendes, Antonio M, Schlegelmilch, Timm, Cohuet, Anna, Awono-Ambene, Parfait, De Iorio, Maria, Fontenille, Didier, Morlais, Isabelle, Christophides, George K, Kafatos, Fotis C, Vlachou, Dina

“…In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient…”
Get full text

Genome Expression Analysis of Anopheles gambiae: Responses to Injury, Bacterial Challenge, and Malaria Infection by Dimopoulos, George, Christophides, George K., Meister, Stephan, Schultz, Jörg, White, Kevin P., Barillas-Mury, Carolina, Kafatos, Fotis C.

“…The complex gene expression responses of Anopheles gambiae to microbial and malaria challenges, injury, and oxidative stress (in the mosquito and/or a cultured…”
Get full text

The Roles of Two Clip Domain Serine Proteases in Innate Immune Responses of the Malaria Vector Anopheles gambiae by Volz, Jennifer, Osta, Mike A., Kafatos, Fotis C., Müller, Hans-Michael

“…The malaria vector Anopheles gambiae is capable of multiple immune responses against Plasmodium ookinetes. Accumulating evidence in several insect species…”
Get full text

In Vivo Identification of Novel Regulators and Conserved Pathways of Phagocytosis in A. gambiae by Moita, Luís F., Wang-Sattler, Rui, Michel, Kristin, Zimmermann, Timo, Blandin, Stephanie, Levashina, Elena A., Kafatos, Fotis C.

“…Anopheles gambiae uses effective immune responses, including phagocytosis, to fight microbial infection. We have developed a semiquantitative phagocytosis test…”
Get full text

Real‐time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion by Vlachou, Dina, Zimmermann, Timo, Cantera, Rafael, Janse, Chris J., Waters, Andrew P., Kafatos, Fotis C.

“…Summary Invasion of the Anopheles mosquito midgut by the Plasmodium ookinete is a critical step in the malaria transmission cycle. We have generated a…”
Get full text

Arthropod-borne diseases: vector control in the genomics era by Hill, Catherine A, Kafatos, Fotis C, Stansfield, Sally K, Collins, Frank H

“…Diseases that are transmitted by arthropods cause severe morbidity and mortality throughout the world. The burden of many of these diseases is borne largely by…”
Get full text

Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum by Michel, K, Suwanchaichinda, C, Morlais, I, Lambrechts, L, Cohuet, A, Awono-Ambene, P.H, Simard, F, Fontenille, D, Kanost, M.R, Kafatos, F.C

“…Serpins are central to the modulation of various innate immune responses in insects and are suspected to influence the outcome of malaria parasite infection in…”
Get full text