Search Results - "KADOMATSU, Kenji"

Origin and initiation mechanisms of neuroblastoma by Tsubota, Shoma, Kadomatsu, Kenji

“…Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood…”
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Towards the in vivo identification of protein–protein interactions by Suzuki, Yuji, Kadomatsu, Kenji, Sakamoto, Kazuma

“…Abstract Protein–protein interactions (PPIs) play crucial roles in biological processes. The conventional methods based on affinity purification of a protein…”
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Midkine: an emerging target of drug development for treatment of multiple diseases by Muramatsu, Takashi, Kadomatsu, Kenji

“…Midkine is a multifunctional factor and has anti‐apoptotic, migration‐promoting, angiogenic, anti‐microbial and other activities. Midkine ameliorates ischemic…”
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Mechanisms of axon regeneration: The significance of proteoglycans by Sakamoto, Kazuma, Kadomatsu, Kenji

“…Therapeutics specific to neural injury have long been anticipated but remain unavailable. Axons in the central nervous system do not readily regenerate after…”
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miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury by Funahashi, Yoshio, Kato, Noritoshi, Masuda, Tomohiro, Nishio, Fumitoshi, Kitai, Hiroki, Ishimoto, Takuji, Kosugi, Tomoki, Tsuboi, Naotake, Matsuda, Naoyuki, Maruyama, Shoichi, Kadomatsu, Kenji

“…Development of a novel agent against life-threatening sepsis requires the in-depth understanding of the relevant pathophysiology and therapeutic targets. Given…”
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Type IIa RPTPs and Glycans: Roles in Axon Regeneration and Synaptogenesis by Sakamoto, Kazuma, Ozaki, Tomoya, Suzuki, Yuji, Kadomatsu, Kenji

“…Type IIa receptor tyrosine phosphatases (RPTPs) play pivotal roles in neuronal network formation. It is emerging that the interactions of RPTPs with glycans,…”
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Combination of tumor necrosis factor‐α and epidermal growth factor induces the adrenergic‐to‐mesenchymal transdifferentiation in SH‐SY5Y neuroblastoma cells by Huang, Yue, Tsubota, Shoma, Nishio, Nobuhiro, Takahashi, Yoshiyuki, Kadomatsu, Kenji

“…Neuroblastoma, a type of cancer that is common in children, is composed of two genetically clonal but epigenetically distinct cell types: mesenchymal (MES) and…”
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Mechanisms of axon regeneration and its inhibition: Roles of sulfated glycans by Kadomatsu, Kenji, Sakamoto, Kazuma

“…•Axons in the central nervous system do not readily regenerate.•Here, the positive and negative regulations of axon regeneration are addressed.•Chondroitin…”
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Close association of polarization and LC3, a marker of autophagy, in axon determination in mouse hippocampal neurons by Segi, Naoki, Ozaki, Tomoya, Suzuki, Yuji, Ouchida, Jun, Imagama, Shiro, Kadomatsu, Kenji, Sakamoto, Kazuma

“…The autophagy-lysosome pathway is a cellular clearance system for intracellular organelles, macromolecules and microorganisms. It is indispensable for cells…”
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Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN‐amplified neuroblastoma cells by Yamashita, Ken, Kiyonari, Shinichi, Tsubota, Shoma, Kishida, Satoshi, Sakai, Ryuichi, Kadomatsu, Kenji

“…MYCN gene amplification is consistently associated with poor prognosis in patients with neuroblastoma, a pediatric tumor arising from the sympathetic nervous…”
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Identification of PTPRσ-interacting proteins by proximity-labelling assay by Gong, Yuanhao, Abudureyimu, Shaniya, Kadomatsu, Kenji, Sakamoto, Kazuma

“…Abstract Receptor protein tyrosine phosphatases (RPTPs) are type-I transmembrane proteins and involved in various biological and pathological processes. Their…”
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The heparin-binding growth factor midkine: the biological activities and candidate receptors by Kadomatsu, Kenji, Kishida, Satoshi, Tsubota, Shoma

“…The heparin-binding growth factor midkine (MK) comprises a family with pleiotrophin/heparin-binding growth-associated molecule. The biological phenomena in…”
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PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma by Tsubota, Shoma, Kishida, Satoshi, Shimamura, Teppei, Ohira, Miki, Yamashita, Satoshi, Cao, Dongliang, Kiyonari, Shinichi, Ushijima, Toshikazu, Kadomatsu, Kenji

“…Pediatric cancers such as neuroblastoma are thought to involve a dysregulation of embryonic development. However, it has been difficult to identify the…”
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Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice by Takemoto, Yoshio, Horiba, Mitsuru, Harada, Masahide, Sakamoto, Kazuma, Takeshita, Kyosuke, Murohara, Toyoaki, Kadomatsu, Kenji, Kamiya, Kaichiro

“…Background:A recent study suggested that midkine (MK), a heparin-binding growth factor, is associated with atherosclerosis progression in patients with artery…”
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Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma by Ho, Wan-Ling, Hsu, Wen-Ming, Huang, Min-Chuan, Kadomatsu, Kenji, Nakagawara, Akira

“…Glycosylation is the most complex post-translational modification of proteins. Altered glycans on the tumor- and host-cell surface and in the tumor…”
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Midkine in the pathology of cancer, neural disease, and inflammation by Sakamoto, Kazuma, Kadomatsu, Kenji

“…Midkine (MK) is a heparin‐binding growth factor involved in various cellular processes such as cellular proliferation, survival, and migration. In addition to…”
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Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis by Sakamoto, Kazuma, Ozaki, Tomoya, Ko, Yen-Chun, Tsai, Cheng-Fang, Gong, Yuanhao, Morozumi, Masayoshi, Ishikawa, Yoshimoto, Uchimura, Kenji, Nadanaka, Satomi, Kitagawa, Hiroshi, Zulueta, Medel Manuel L., Bandaru, Anandaraju, Tamura, Jun-ichi, Hung, Shang-Cheng, Kadomatsu, Kenji

“…Chondroitin sulfate (CS) and heparan sulfate (HS) are glycosaminoglycans that both bind the receptor-type protein tyrosine phosphatase PTPRσ, affecting axonal…”
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Dermatan sulphate is an activating ligand of anaplastic lymphoma kinase by Machino, Masaaki, Gong, Yuanhao, Ozaki, Tomoya, Suzuki, Yuji, Watanabe, Eri, Imagama, Shiro, Kadomatsu, Kenji, Sakamoto, Kazuma

“…Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that harbours a tyrosine kinase domain in its intracellular region and is…”
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GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain by Narentuya, Takeda-Uchimura, Yoshiko, Foyez, Tahmina, Zhang, Zui, Akama, Tomoya O., Yagi, Hirokazu, Kato, Koichi, Komatsu, Yukio, Kadomatsu, Kenji, Uchimura, Kenji

“…Keratan sulfate (KS) is a carbohydrate side chain covalently attached to extracellular proteoglycans. KS is composed of disaccharide units of 6-sulfated N…”
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Sulfated glycans in network rewiring and plasticity after neuronal injuries by Kadomatsu, Kenji, Sakamoto, Kazuma

“…Biopolymers in the human body belong to three major classes: polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (glycans). Although…”
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