Search Results - "KACEVSKA, Marina"

Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause? by van der Poorten, David, Samer, Caroline F., Ramezani‐Moghadam, Mehdi, Coulter, Sally, Kacevska, Marina, Schrijnders, Dennis, Wu, Lindsay E., McLeod, Duncan, Bugianesi, Elisabetta, Komuta, Mina, Roskams, Tania, Liddle, Christopher, Hebbard, Lionel, George, Jacob

“…Advanced liver fibrosis in nonalcoholic steatohepatitis (NASH) is often accompanied by a reduction in hepatic fat to the point of complete fat loss (burnt‐out…”
Get full text

Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer by Morgan, Edward T, Goralski, Kerry B, Piquette-Miller, Micheline, Renton, Kenneth W, Robertson, Graham R, Chaluvadi, Madhusudana R, Charles, Kellie A, Clarke, Stephen J, Kacevska, Marina, Liddle, Christopher, Richardson, Terrilyn A, Sharma, Rohini, Sinal, Christopher J

“…This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology…”
Get full text

DNA methylation dynamics in the hepatic CYP3A4 gene promoter by Kacevska, Marina, Ivanov, Maxim, Wyss, Annika, Kasela, Silva, Milani, Lili, Rane, Anders, Ingelman-Sundberg, Magnus

“…The CYP3A4 gene, encoding the major drug metabolizing enzyme in humans, exhibits a high interindividual variation in hepatic expression that can lead to…”
Get full text

Extrahepatic Cancer Suppresses Nuclear Receptor―Regulated Drug Metabolism by KACEVSKA, Marina, DOWNES, Michael R, SHARMA, Rohini, EVANS, Ronald M, CLARKE, Stephen J, LIDDLE, Christopher, ROBERTSON, Graham R

“…To determine the mechanisms by which tumors situated in extrahepatic sites can cause profound changes in hepatic drug clearance, contributing to altered drug…”
Get full text

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function by Ivanov, Maxim, Kals, Mart, Kacevska, Marina, Barragan, Isabel, Kasuga, Kie, Rane, Anders, Metspalu, Andres, Milani, Lili, Ingelman-Sundberg, Magnus

“…BACKGROUND: Interindividual differences in liver functions such as protein synthesis, lipid and carbohydrate metabolism and drug metabolism are influenced by…”
Get full text

In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes by Ivanov, Maxim, Kals, Mart, Kacevska, Marina, Metspalu, Andres, Ingelman-Sundberg, Magnus, Milani, Lili

“…DNA methylation is one of the most important epigenetic alterations involved in the control of gene expression. Bisulfite sequencing of genomic DNA is…”
Get full text

Epigenetic-dependent regulation of drug transport and metabolism: an update by Kacevska, Marina, Ivanov, Maxim, Ingelman-Sundberg, Magnus

“…The pharmacokinetics of a drug are subject to large interindividual variability, which can result in lack of response or adverse drug reactions. In addition to…”
Get more information

Systemic Inflammatory Response Predicts Prognosis in Patients with Advanced-Stage Colorectal Cancer by Sharma, Rohini, Zucknick, Manuela, London, Roslyn, Kacevska, Marina, Liddle, Christopher, Clarke, Stephen J

“…Abstract We aim to confirm the prognostic value of an inflammation-based prognostic score (the Glasgow Prognostic Score [GPS]) in advanced colorectal cancer,…”
Get full text

Extra-Hepatic Cancer Represses Hepatic Drug Metabolism Via Interleukin (IL)-6 Signalling by Kacevska, Marina, Mahns, Andre, Sharma, Rohini, Clarke, Stephen J., Robertson, Graham R., Liddle, Christopher

“…Purpose In many cancer patients, the malignancy causes reduced hepatic drug clearance leading to potentially serious complications from the use of anticancer…”
Get full text

Inflammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing by Kacevska, Marina, Robertson, Graham R, Clarke, Stephen J, Liddle, Christopher

“…The inability to accurately predict treatment outcomes for cancer patients in terms of tumour response and anticancer drug toxicity is a severe limitation…”
Get more information

Extra-Hepatic Cancer Represses Hepatic Drug Metabolism Via Interleukin (IL)-6 Signalling : Disease, Drug Metabolism, and Transporter Interactions by KACEVSKA, Marina, MAHNS, Andre, SHARMA, Rohini, CLARKE, Stephen J, ROBERTSON, Graham R, LIDDLE, Christopher

Get full text

EXTRA-HEPATIC CANCER SUPPRESSES NUCLEAR RECEPTOR REGULATED DRUG METABOLISM by Kacevska, Marina, Downes, Michael R., Sharma, Rohini, Evans, Ronald M., Clarke, Stephen J., Liddle, Christopher, Robertson, Graham R.

Get full text