Search Results - "KABESCH, Michael"

Focusing on severe infections with the respiratory syncytial virus (RSV) in adults: Risk factors, symptomatology and clinical course compared to influenza A / B and the original SARS-CoV-2 strain by Ambrosch, Andreas, Luber, Doris, Klawonn, Frank, Kabesch, Michael

“…•RSV is the second most prevalent respiratory virus in adults before the COVID pandemic.•85% of RSV patients had risk factors, with COPD and kidney disease…”
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Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children by Resch, Yvonne, MSc, Michel, Sven, MSc, Kabesch, Michael, MD, Lupinek, Christian, MD, Valenta, Rudolf, MD, Vrtala, Susanne, PhD

“…Background House dust mites (HDMs) represent one of the most important inducers of respiratory allergies worldwide. Objective We sought to investigate the IgE…”
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Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma by Depner, Martin, Taft, Diana Hazard, Kirjavainen, Pirkka V., Kalanetra, Karen M., Karvonen, Anne M., Peschel, Stefanie, Schmausser-Hechfellner, Elisabeth, Roduit, Caroline, Frei, Remo, Lauener, Roger, Divaret-Chauveau, Amandine, Dalphin, Jean-Charles, Riedler, Josef, Roponen, Marjut, Kabesch, Michael, Renz, Harald, Pekkanen, Juha, Farquharson, Freda M., Louis, Petra, Mills, David A., von Mutius, Erika, Ege, Markus J.

“…Growing up on a farm is associated with an asthma-protective effect, but the mechanisms underlying this effect are largely unknown. In the Protection against…”
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Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study by Fill Malfertheiner, Sara, Brandstetter, Susanne, Roth, Samra, Harner, Susanne, Buntrock-Döpke, Heike, Toncheva, Antoaneta A., Borchers, Natascha, Gruber, Rudolf, Ambrosch, Andreas, Kabesch, Michael, Häusler, Sebastian

“…Currently, little is known about the progression of an immune response against SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the…”
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Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects by Saunders, Sean P., PhD, Goh, Christabelle S.M., BSc, Brown, Sara J., MD, Palmer, Colin N.A., PhD, Porter, Rebecca M., PhD, Cole, Christian, PhD, Campbell, Linda E., MSc, Gierlinski, Marek, PhD, Barton, Geoffrey J., PhD, Schneider, Georg, PhD, Balmain, Allan, PhD, Prescott, Alan R., PhD, Weidinger, Stephan, MD, PhD, Baurecht, Hansjörg, PhD, Kabesch, Michael, MD, Gieger, Christian, PhD, Lee, Young-Ae, MD, Tavendale, Roger, PhD, Mukhopadhyay, Somnath, MD, Turner, Stephen W., MD, Madhok, Vishnu B., MD, Sullivan, Frank M., MD, Relton, Caroline, PhD, Burn, John, MD, Meggitt, Simon, MD, Smith, Catherine H., MD, Allen, Michael A., PhD, Barker, Jonathan N.W. N., MD, Reynolds, Nick J., MD, Cordell, Heather J., DPhil, Irvine, Alan D., MD, McLean, W.H. Irwin, DSc, Sandilands, Aileen, PhD, Fallon, Padraic G., PhD

“…Background Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin…”
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Filaggrin mutations, atopic eczema, hay fever, and asthma in children by Weidinger, Stephan, MD, O'Sullivan, Maureen, MD, Illig, Thomas, PhD, Baurecht, Hansjörg, MSc, Depner, Martin, MSc, Rodriguez, Elke, MSc, Ruether, Andreas, PhD, Klopp, Norman, PhD, Vogelberg, Christian, MD, Weiland, Stephan K., MD, McLean, W.H. Irwin, PhD, DSc, FRSE, von Mutius, Erika, MD, Irvine, Alan D., MD, Kabesch, Michael, MD

“…Background Mutations in the filaggrin gene ( FLG ) have been shown to play a significant role in ichthyosis vulgaris and eczema, 2 common chronic skin…”
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Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes by Schmitt, Jochen, MD, MPH, Schwarz, Kristin, MSc, Baurecht, Hansjörg, MSc, Hotze, Melanie, MSc, Fölster-Holst, Regina, MD, Rodríguez, Elke, PhD, Lee, Young A.E., MD, Franke, Andre, PhD, Degenhardt, Frauke, MSc, Lieb, Wolfgang, PhD, Gieger, Christian, PhD, Kabesch, Michael, MD, Nöthen, Markus M., MD, Irvine, Alan D., MD, McLean, W.H. Irwin, PhD, Deckert, Stefanie, MPH, Stephan, Victoria, Schwarz, Peter, MD, Aringer, Martin, MD, Novak, Natalija, MD, Weidinger, Stephan, MD, MaHM

“…Background Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for…”
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Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion by Lluis, Anna, MSc, Schedel, Michaela, PhD, Liu, Jing, MD, Illi, Sabina, PhD, Depner, Martin, MSc, von Mutius, Erika, MD, Kabesch, Michael, MD, Schaub, Bianca, MD

“…Background In a genome-wide association study, genetic variants on chromosome 17q21 were strongly associated with childhood asthma and orosomucoid 1–like 3…”
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Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci by Ellinghaus, David, Ellinghaus, Eva, Nair, Rajan P., Stuart, Philip E., Esko, Tõnu, Metspalu, Andres, Debrus, Sophie, Raelson, John V., Tejasvi, Trilokraj, Belouchi, Majid, West, Sarah L., Barker, Jonathan N., Kõks, Sulev, Kingo, Külli, Balschun, Tobias, Palmieri, Orazio, Annese, Vito, Gieger, Christian, Wichmann, H. Erich, Kabesch, Michael, Trembath, Richard C., Mathew, Christopher G., Abecasis, Gonçalo R., Weidinger, Stephan, Nikolaus, Susanna, Schreiber, Stefan, Elder, James T., Weichenthal, Michael, Nothnagel, Michael, Franke, Andre

“…Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their…”
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Europe-wide comparison regarding the first medical examination of the newborn after birth: Absence of uniform standards by Plail, Linda, Wellmann, Sven, Apfelbacher, Christian, Kabesch, Michael

“…The first medical examination of the newborn after birth plays an essential role in identifying congenital malformations and life-threatening conditions…”
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Allergy skin prick tests with COVID-19 vaccines and their contribution to improve vaccination readiness and reduce anxiety by Pindel, Tobias, Brandstetter, Susanne, Sieber, Wolfgang, Kabesch, Michael

“…Background When coronavirus disease 2019 (COVID-19) vaccines were introduced, they were suspected of triggering severe allergic reactions disproportionately…”
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Wheeze in preschool age is associated with pulmonary bacterial infection and resolves after antibiotic therapy by Schwerk, Nicolaus, Brinkmann, Folke, Soudah, Bisharah, Kabesch, Michael, Hansen, Gesine

“…Neonates with airways colonized by Haemophilus influenzae, Streptococcus pneumoniae or Moraxella catarrhalis are at increased risk for recurrent wheeze which…”
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A genome-wide association study on African-ancestry populations for asthma by Mathias, Rasika A., ScD, Grant, Audrey V., PhD, Rafaels, Nicholas, MS, Hand, Tracey, MS, Gao, Li, MD, PhD, Vergara, Candelaria, MSc, Tsai, Yuhjung J., MD, Yang, Mao, MS, Campbell, Monica, BS, Foster, Cassandra, Gao, Peisong, MD, PhD, Togias, A., MD, Hansel, Nadia N., MD, MPH, Diette, Gregory, MD, Adkinson, N. Franklin, MD, Liu, Mark C., MD, Faruque, Mezbah, MD, PhD, Dunston, Georgia M., PhD, Watson, Harold R., MD, Bracken, Michael B., PhD, Hoh, Josephine, PhD, Maul, Pissamai, RN, Maul, Trevor, RN, Jedlicka, Anne E., MS, Murray, Tanda, MS, Hetmanski, Jacqueline B., MS, Ashworth, Roxann, MHS, Ongaco, Chrissie M., BS, Hetrick, Kurt N., MS, Doheny, Kimberly F., PhD, Pugh, Elizabeth W., PhD, MPH, Rotimi, Charles N., PhD, Ford, Jean, MD, Eng, Celeste, BS, Burchard, Esteban G., MD, Sleiman, Patrick M.A., PhD, Hakonarson, Hakon, MD, PhD, Forno, Erick, MD, Raby, Benjamin A., MD, Weiss, Scott T., MD, Scott, Alan F., PhD, Kabesch, Michael, MD, Liang, Liming, MS, Abecasis, Gonçalo, PhD, Moffatt, Miriam F., PhD, Cookson, William O.C., MD, Ruczinski, Ingo, PhD, Beaty, Terri H., PhD, Barnes, Kathleen C., PhD

“…Background Asthma is a complex disease characterized by striking ethnic disparities not explained entirely by environmental, social, cultural, or economic…”
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Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts by Hose, Alexander J., MA, MPH, Depner, Martin, PhD, Illi, Sabina, PhD, Lau, Susanne, MD, PhD, Keil, Thomas, MD, MScPH, Wahn, Ulrich, MD, Fuchs, Oliver, MD, PhD, Pfefferle, Petra Ina, PhD, DrPH, Schmaußer-Hechfellner, Elisabeth, BSc, Genuneit, Jon, MD, Lauener, Roger, MD, Karvonen, Anne M., PhD, Roduit, Caroline, MD, Dalphin, Jean-Charles, MD, PhD, Riedler, Josef, MD, Pekkanen, Juha, MD, PhD, von Mutius, Erika, MD, Ege, Markus J., MD

“…Background Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during…”
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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma by Strachan, David, von Berg, Andrea, Rietschel, Ernst, Liang, Liming, Dixon, Anna L, Moffatt, Miriam F, Gut, Ivo G, Kabesch, Michael, Bufe, Albrecht, Depner, Martin, Simma, Burkard, Cookson, William O. C, Vogelberg, Christian, Weiland, Stephan K, Abecasis, Gonçalo R, Illig, Thomas, Wong, Kenny C. C, Heath, Simon, Lathrop, G. Mark, Heinzmann, Andrea, Willis-Owen, Saffron A. G, Frischer, Thomas, von Mutius, Erika, Farrall, Martin

“…Asthma is caused by a combination of poorly understood genetic and environmental factors. We have systematically mapped the effects of single nucleotide…”
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A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis by Schaarschmidt, Heidi, ME, Ellinghaus, David, PhD, Rodríguez, Elke, PhD, Kretschmer, Anja, PhD, Baurecht, Hansjörg, MSc, Lipinski, Simone, PhD, Meyer-Hoffert, Ulf, MD, PhD, Harder, Jürgen, PhD, Lieb, Wolfgang, MD, Novak, Natalija, MD, Fölster-Holst, Regina, MD, Esparza-Gordillo, Jorge, PhD, Marenholz, Ingo, PhD, Ruschendorf, Franz, PhD, Hubner, Norbert, PhD, Reischl, Eva, PhD, Waldenberger, Melanie, PhD, Gieger, Christian, PhD, Illig, Thomas, PhD, Kabesch, Michael, MD, Zhang, Xue-Jun, MD, Xiao, Feng-Li, PhD, Lee, Young-Ae, MD, Franke, Andre, PhD, Weidinger, Stephan, MD

“…Regarding susceptibility loci reported exclusively in GWASs of Asian populations, 5 loci (GLB1, CCDC80, ZNF365, OR10A/3/NLRP10, and CYP24A1/PFDN4) showed…”
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A functional IL-6 receptor ( IL6R ) variant is a risk factor for persistent atopic dermatitis by Esparza-Gordillo, Jorge, PhD, Schaarschmidt, Heidi, ME, Liang, Liming, PhD, Cookson, William, MD, DPhil, Bauerfeind, Anja, PhD, Lee-Kirsch, Min-Ae, MD, Nemat, Katja, MD, Henderson, John, MD, Paternoster, Lavinia, PhD, Harper, John I., MD, Mangold, Elisabeth, MD, Nothen, Markus M., MD, Rüschendorf, Franz, PhD, Kerscher, Tamara, PhD, Marenholz, Ingo, PhD, Matanovic, Anja, MSc, Lau, Susanne, MD, Keil, Thomas, MD, MSc, Bauer, Carl-Peter, MD, Kurek, Michael, MD, Ciechanowicz, Andrzej, MD, Macek, Milan, MD, DSc, Franke, Andre, PhD, Kabesch, Michael, MD, Hubner, Norbert, MD, Abecasis, Gonçalo, PhD, Weidinger, Stephan, MD, Moffatt, Miriam, DPhil, Lee, Young-Ae, MD

“…Background Atopic dermatitis (AD) is a common inflammatory skin disease. Previous studies have revealed shared genetic determinants among different…”
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Effects of Early Emollient Use in Children at High Risk of Atopic Dermatitis: A German Pilot Study by Harder, Inken, Stölzl, Dora, Sander, Nicole, Hartmann, Jan, Rodriguez, Elke, Mazur, Carsten, Kerzel, Sebastian, Kabesch, Michael, Küster, Denise, Schmitt, Jochen, Fölster-Holst, Regina, Gerdes, Sascha, Emmert, Hila, Weidinger, Stephan

“…Several small studies have indicated that daily emollient use from birth might delay, suppress or prevent atopic dermatitis (AD). Two larger trials did not…”
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Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools by Sweeney-Reed, Catherine M., Wolff, Doreen, Hörnschemeyer, Sarah, Faßhauer, Henriette, Haase, Antonia, Schomburg, Dirk, Niggel, Jakob, Kabesch, Michael, Apfelbacher, Christian

“…School closures have a negative impact on physical and mental well-being, and education, of children and adolescents. A surveillance programme to detect…”
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1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter by Schedel, Michaela, Jia, Yi, Michel, Sven, Takeda, Katsuyuki, Domenico, Joanne, Joetham, Anthony, Ning, Fangkun, Strand, Matthew, Han, Junyan, Wang, Meiqin, Lucas, Joseph J., Vogelberg, Christian, Kabesch, Michael, O’Connor, Brian P., Gelfand, Erwin W.

“…Effector CD8 + T cells convert from IFN-γ + (Tc1) to IL-13 + (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here,…”
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