Search Results - "KABALKA, George W"

A novel catalytic process for trifluoromethylation of bromoaromatic compounds by Samant, Bhupesh S, Kabalka, George W

“…The palladium-catalyzed trifluoromethylation of aryl bromides has been achieved in micellar media. The micellar conditions result in enhanced yields and are…”
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Biodistribution and subcellular localization of an unnatural boron-containing amino acid (cis-ABCPC) by imaging secondary ion mass spectrometry for neutron capture therapy of melanomas and gliomas by Chandra, Subhash, Barth, Rolf F, Haider, Syed A, Yang, Weilian, Huo, Tianyao, Shaikh, Aarif L, Kabalka, George W

“…The development of new boron-delivery agents is a high priority for improving the effectiveness of boron neutron capture therapy. In the present study,…”
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Synthesis of [18 F]FMISO in a flow-through microfluidic reactor: Development and clinical application by Zheng, Ming-Qiang, Collier, Lee, Bois, Frederic, Kelada, Olivia J, Hammond, Kelvin, Ropchan, Jim, Akula, Murthy R, Carlson, David J, Kabalka, George W, Huang, Yiyun

“…Abstract Introduction The PET radiotracer [18 F]FMISO has been used in the clinic to image hypoxia in tumors. The aim of the present study was to optimize the…”
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Palladium-Catalyzed Cross-Coupling of Acetates of Baylis−Hillman Adducts and Potassium Organotrifluoroborates by Kabalka, George W, Venkataiah, Bollu, Dong, Gang

“…The cross-coupling of potassium organotrifluoroborates and acetates of Baylis−Hillman adducts proceeds readily in moderate to excellent yield in the presence…”
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Microwave-Enhanced Palladium-Catalyzed Cross-Coupling Reactions of Potassium Vinyltrifluoroborates and Allyl Acetates:  A New Route to 1,4-Pentadienes by Kabalka, George W, Al-Masum, Mohammad

“…A novel and straightforward microwave synthesis of 1,4-pentadienes has been developed involving the cross-coupling of potassium vinyltrifluoroborates and allyl…”
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Evaluation of unnatural cyclic amino acids as boron delivery agents for treatment of melanomas and gliomas by Barth, Rolf F., Kabalka, George W., Yang, Weilian, Huo, Tianyao, Nakkula, Robin J., Shaikh, Aarif L., Haider, Syed A., Chandra, Subhash

“…Unnatural cyclic amino acids (UNAAs) are a new class of boron delivery agents that are in a pre-clinical stage of evaluation. In the present study, the…”
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Generation of Cations from Alkoxides:  Allylation of Propargyl Alcohols by Kabalka, George W, Yao, Min-Liang, Borella, Scott

“…The reaction of alkoxides with boron trichloride results in the generation of cations in the absence of Brønsted acids. The absence of a Brønsted acid can make…”
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Sonogashira coupling and cyclization reactions on alumina: a route to aryl alkynes, 2-substituted-benzo[ b]furans and 2-substituted-indoles by Kabalka, George W, Wang, Lei, Pagni, Richard M

“…A solventless, microwave-enhanced Sonogashira coupling reaction of aromatic iodides with terminal alkynes on potassium fluoride doped alumina in the presence…”
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The synthesis and use of boronated amino acids for boron neutron capture therapy by Kabalka, George W, Yao, Min-Liang

“…The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer…”
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Effects of l-DOPA pre-loading on the uptake of boronophenylalanine using the F98 glioma and B16 melanoma models by Yang, Weilian, Barth, Rolf F., Huo, Tianyao, Kabalka, George W., Shaikh, Aarif L., Haider, Syed A., Chandra, Subhash

“…The present study was undertaken to evaluate the effects of l-DOPA pre-loading on the uptake of BPA using the F98 rat glioma and the murine B16 melanoma…”
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Identification of a Boron-Containing Intermediate in the Boron Tribromide Mediated Aryl Propargyl Ether Cleavage Reaction by Yao, Min-Liang, Reddy, Marepally Srinivasa, Zeng, Wenbin, Hall, Kelly, Walfish, Ingrid, Kabalka, George W

“…An alternate reaction mechanism for the boron tribromide mediated deprotection of aryl propargyl ethers based on the isolation of a key boron-containing…”
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Isotope incorporation using organoboranes by Kabalka, George W., Yao, Min-Liang, Akula, Murthy, Yong, Li

“…Isotopes have played an important role in chemistry, biology, and medicine. For the last three decades, we have focused on the use of organoboron compounds as…”
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Microwave-enhanced cross-coupling reactions involving alkynyltrifluoroborates with aryl bromides by Coltuclu, Vitali, Dadush, Eric, Naravane, Abhijit, Kabalka, George W

“…Palladium-catalyzed alkynylation has emerged as one of the most reliable methods for the synthesis of alkynes which are often used in natural product syntheses…”
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Titanium(IV) Halide Mediated Coupling of Alkoxides and Alkynes: An Efficient and Stereoselective Route to Trisubstituted (E)-Alkenyl Halides by Yao, Min-Liang, Quick, Travis R, Wu, Zhongzhi, Quinn, Michael P, Kabalka, George W

“…Alkoxide C−O bond cleavage occurs readily at room temperature in the presence of titanium(IV) halide. Capture of the resultant carbocation by alkynes provides…”
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A rapid microfluidic synthesis of [18F]fluoroarenes from nitroarenes by Moore, Thomas M., Akula, Murthy R., Collier, Lee, Kabalka, George W.

“…Microfluidic radiofluorodenitrations have been successfully performed using a commercially available microfluidic synthesis system. Reactions of nitroarenes…”
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Iron Trichloride Mediated Allylation of Lithium Alkoxides through an Unusual Carbon−Oxygen Bond Cleavage by Kabalka, George W, Yao, Min-Liang, Borella, Scott, Goins, Laura K

“…Iron trichloride was found to cleave carbon−oxygen bonds in a variety of lithium alkoxides at room temperature. Other Lewis acids were also found to cleave the…”
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Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy by Kabalka, George W., Shaikh, Aarif L., Barth, Rolf F., Huo, Tianyao, Yang, Weilian, Gordnier, Pamela M., Chandra, Subhash

“…Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in…”
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Design, synthesis, and biological evaluation of 4-(5-dimethylamino-naphthalene-1-sulfon-amido)-3-(4-iodophenyl)butanoic acid as a novel molecular probe for apoptosis imaging by Zeng, Wenbin, Miao, Weimin, Le Puil, Michael, Shi, Guangqing, Biggerstaff, John, Kabalka, George W., Townsend, David

“…► Annexin V is the gold standard probe for imaging apoptosis. ► Unfavorable profiles of Annexin V make it difficult to apply in the clinic. ► A novel…”
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Synthesis of a series of boronated unnatural cyclic amino acids as potential boron neutron capture therapy agents by Kabalka, George W., Wu, Zhongzhi, Yao, Min-Liang

“…New boronated unnatural cyclic amino acids, 1–6, were synthesized for potential use in neutron capture therapy. In order to understand the effect of molecular…”
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A New Halopropargylation of Alkynes Promoted by Boron Trihalides. Highly Stereo- and Regioselective Syntheses of Substituted (Z)-1-Halo-1,4-enyne Derivatives by Kabalka, George W, Wu, Zhongzhi, Ju, Yuhong

“…A new halopropargylation of alkynes promoted by boron trihalides has been developed. Reactions of (Z)-2-halo-1-vinylboron dihalides (generated in situ via…”
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