Search Results - "KAARSHOLM, N. C"
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1
Properties of Small Molecules Affecting Insulin Receptor Function
Published in Biochemistry (Easton) (13-11-2001)“…Small molecules with insulin mimetic effects and oral availability are of interest for potential substitution of insulin injections in the treatment of…”
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2
Spectroscopic signatures of the T to R conformational transition in the insulin hexamer
Published in The Journal of biological chemistry (15-11-1989)“…The cobalt(II)-substituted human insulin hexamer has been shown to undergo the phenol-induced T6 to R6 structural transition in solution. The accompanying…”
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3
Ligand-induced conformation change in folate-binding protein
Published in Biochemical journal (15-06-1993)“…C.d. and fluorescence spectroscopy have been used to investigate the effect of ligand binding on the structure and stability of folate-binding protein (FBP)…”
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4
Engineering stability of the insulin monomer fold with application to structure-activity relationships
Published in Biochemistry (Easton) (12-10-1993)“…To evaluate the possible relationship between biological activity and structural stability in selected regions of the insulin molecule, we have analyzed the…”
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5
Allosteric transition of the insulin hexamer is modulated by homotropic and heterotropic interactions
Published in Biochemistry (Easton) (02-11-1993)“…The allosteric behavior of the Co(II)-substituted insulin hexamer has been investigated using electronic spectroscopy to study the binding of different…”
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6
Ionization behavior of native and mutant insulins: pK perturbation of B13-Glu in aggregated species
Published in Archives of biochemistry and biophysics (01-12-1990)“…Upscale titration from pH 2.5 to 11.2 is used as a means for probing solvent accessibility of ionizing groups in zinc-free preparations of native and mutant…”
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7
Characterization of the r-state insulin hexamer and its derivatives. The hexamer is stabilized by heterotropic ligand binding interactions
Published in Biochemistry (Easton) (09-07-1991)“…1H NMR and UV-visible electronic absorption studies have been performed to investigate the effects of anions and cyclic organic molecules on the…”
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8
Engineering-enhanced Protein Secretory Expression in Yeast with Application to Insulin
Published in The Journal of biological chemistry (24-05-2002)“…Adaptation to efficient heterologous expression is a prerequisite for recombinant proteins to fulfill their clinical and biotechnological potential. We…”
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9
The pro region required for folding of carboxypeptidase Y is a partially folded domain with little regular structural core
Published in Biochemistry (Easton) (16-11-1993)“…The pro region of carboxypeptidase Y (CPY) from yeast is necessary for the correct folding of the enzyme [Winther, J.R., and Sorensen P. (1991) Proc. Natl…”
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10
A structural switch in a mutant insulin exposes key residues for receptor binding
Published in Journal of molecular biology (29-05-1998)“…Despite years of effort to clarify the structural basis of insulin receptor binding no clear consensus has emerged. It is generally believed that insulin…”
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11
Solution Structure of an Engineered Insulin Monomer at Neutral pH
Published in Biochemistry (Easton) (09-07-1996)“…Insulin circulates in the bloodstream and binds to its specific cell-surface receptor as a 5808 Da monomeric species. However, studies of the monomer structure…”
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12
Structural Effects of Protein Lipidation as Revealed by LysB29-myristoyl, des(B30) Insulin
Published in Biochemistry (Easton) (03-10-2000)“…Intracellular proteins are frequently modified by covalent addition of lipid moieties such as myristate. Although a functional role of protein lipidation is…”
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13
Studies of the association and conformational properties of metal-free insulin in alkaline sodium chloride solutions by one- and two-dimensional 1H NMR
Published in The Journal of biological chemistry (05-05-1992)“…One- and two-dimensional 1H NMR spectroscopy have been employed to probe the association and subsequent conformational changes of metal-free insulin in sodium…”
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14
The R-state proinsulin and insulin hexamers mimic the carbonic anhydrase active site
Published in The Journal of biological chemistry (15-09-1990)“…The cobalt(II)-substituted proinsulin and insulin hexamers have been studied in solution via electronic absorption spectroscopy. Hexameric proinsulin is shown…”
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15
Mechanisms of Stabilization of the Insulin Hexamer through Allosteric Ligand Interactions
Published in Biochemistry (Easton) (13-05-1997)“…The insulin hexamer is an allosteric protein capable of undergoing transitions between three conformational states: T6, T3R3, and R6. These transitions are…”
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16
The relationship between insulin bioactivity and structure in the NH2-terminal A-chain helix
Published in Journal of molecular biology (27-11-1998)“…Studies of naturally occuring and chemically modified insulins have established that the NH2-terminal helix of the A-chain is important in conferring affinity…”
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17
High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy
Published in Biochemistry (Easton) (05-07-1994)“…Site-directed mutagenesis is used in conjunction with 1H nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy in order to find an insulin…”
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18
Subsite differences between the active centres of papaya peptidase A and papain as revealed by affinity chromatography. Purification of papaya peptidase A by ionic-strength-dependent affinity adsorption on an immobilized peptide inhibitor of papain
Published in Biochemical journal (01-05-1984)“…An affinity column consisting of the specific peptide inhibitor of papain, Gly-Gly (O-benzyl)Tyr-Arg, attached to Sepharose was found to bind the active thiol…”
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19
Ligand induced conformation change in folate binding protein
Published in Advances in experimental medicine and biology (01-01-1993)Get more information
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20
Active site ionizations of papaya proteinase A
Published in Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry (01-09-1987)Get more information
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