Search Results - "KAARNIRANTA, K"

What is the meaning of autofluorescence in retinal diseases? by Kaarniranta, K.

“…Summary The fluorophore is fluorescent chemical compound that absorbs light energy of a specific wavelength and re‐emits light at a longer wavelength. The…”
Get full text

Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential by Salminen, A, Lehtonen, M, Suuronen, T, Kaarniranta, K, Huuskonen, J

“…Traditional medicine has been a fertile source for revealing novel lead molecules for modern drug discovery. In plants, terpenoids represent a chemical defense…”
Get full text

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors by Kaarniranta, K., Salminen, A.

“…Age-related macular degeneration (AMD) is the most common cause of irreversible loss of central vision. Histopathological studies have demonstrated that…”
Get full text

Life Style Intervention Improves Retinopathy Status-The Finnish Diabetes Prevention Study by Aro, A, Kauppinen, A, Kivinen, N, Selander, T, Kinnunen, K, Tuomilehto, J, Keinänen-Kiukaanniemi, S, Lindström, J, Uusitupa, M, Kaarniranta, K

“…The aim of the study was to find out whether participation in earlier intervention had an effect on the occurrence of retinopathy in study participants. We…”
Get full text

Comparison of the retinal measurements of standard and neurological SD‐OCT applications in MS patients by Paterno, J.J., Kaarniranta, K.

“…Purpose In multiple sclerosis (MS), spectral domain optical coherence tomography (SD‐OCT) provides a tool to evaluate structural retinal changes related to MS…”
Get full text

Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1 by Salminen, A, Ojala, J, Huuskonen, J, Kauppinen, A, Suuronen, T, Kaarniranta, K

“…Research on aging in model organisms has revealed different molecular mechanisms involved in the regulation of the lifespan. Studies on Saccharomyces…”
Get full text

Clearance of autophagy-associated dying retinal pigment epithelial cells – a possible source for inflammation in age-related macular degeneration by Szatmári-Tóth, M, Kristóf, E, Veréb, Z, Akhtar, S, Facskó, A, Fésüs, L, Kauppinen, A, Kaarniranta, K, Petrovski, G

“…Retinal pigment epithelial (RPE) cells can undergo different forms of cell death, including autophagy-associated cell death during age-related macular…”
Get full text

Serum adiponectin associates with aging rather than neovascular AMD by Paterno, J.J., Kauppinen, A., Kaarniranta, K.

“…Purpose To study whether adiponectin serum levels are changed in neovascular AMD. Adiponectin, secreted primarily by adipocytes, modulates cellular energy…”
Get full text

Autophagy induction decreases protein aggregation in response to polyphenolic pinosylvin and heat shock exposures in ARPE‐19 cells by Amirkavei, M., Koskela, A., Koskelainen, A., kaarniranta, K.

“…Purpose Impaired protein degradation and increased protein aggregation in retinal pigment epithelium (RPE) cells associate with the age‐related macular…”
Get full text

Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells by Skottman, H., Muranen, J., Lähdekorpi, H., Pajula, E., Mäkelä, K., Koivusalo, L., Koistinen, A., Uusitalo, H., Kaarniranta, K., Juuti-Uusitalo, K.

“…Here we evaluated the effects of human retinal microvascular endothelial cells (hREC) on mature human embryonic stem cell (hESC) derived retinal pigment…”
Get full text

Inhibition of BET bromodomains alleviates inflammation in human RPE cells by Hytti, M., Tokarz, P., Määttä, E., Piippo, N., Korhonen, E., Suuronen, T., Honkakoski, P., Kaarniranta, K., Lahtela-Kakkonen, M., Kauppinen, A.

“…[Display omitted] Bromodomain-containing proteins are vital for controlling the expression of many pro-inflammatory genes. Consequently, compounds capable of…”
Get full text

Taking a roller coaster ride with autophagy markers p62 and LC3 by Koskela, A., Reinisalo, M., Kaarniranta, K.

“…Purpose Lysosomal autophagy is crucial for the removal of dysfunctional proteins, aggregated cellular material and organelles. Post‐mitotic cells, such as…”
Get full text

Mitochondrial impairment regulates inflammasome activation in human retinal pigment epithelial cells by Korhonen, E., Piippo, N., Hytti, M., Kaarniranta, K., Kauppinen, A.

“…Purpose Dysfunctional mitochondria and excessive inflammasome activation have been shown to play a role in age‐related macular degeneration. The aim of the…”
Get full text

CB2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells by Hytti, M., Andjelic, S., Josifovska, N., Piippo, N., Korhonen, E., Hawlina, M., Kaarniranta, K., Nevalainen, T. J., Petrovski, G., Parkkari, T., Kauppinen, A.

“…A chronic low-level inflammation contributes to the pathogenesis of age-related macular degeneration (AMD), the most common cause of blindness in the elderly…”
Get full text

Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs) by Kinnunen, K., Piippo, N., Loukovaara, S., Hytti, M., Kaarniranta, K., Kauppinen, A.

“…Inflammation is a crucial component in the pathogenesis of many vascular diseases, such as atherosclerosis and diabetes. Inflammasomes are intracellular…”
Get full text

Suppressed heat shock protein response in the kidney of exercise‐trained diabetic rats by Lappalainen, J., Oksala, N. K. J., Laaksonen, D. E., Khanna, S., Kokkola, T., Kaarniranta, K., Sen, C. K., Atalay, M.

“…Impaired expression of heat shock proteins (HSPs) and increased oxidative stress may contribute to the pathophysiology of diabetes by disrupted tissue…”
Get full text

Loss of Nrf‐2 and PGC1‐alpha genes changes macromorphology of the eye and evokes microstructural and pigmentation pattern changes of the retinal pigmented epithelium by Felszeghy, S., Viiri, J., Koskela, A., Paterno, J., Kettunen, M., Jokivarsi, K., Kaarniranta, K.

“…Purpose Nrf2 (NF‐E2‐related factor 2) and PGC1‐ α (peroxisome proliferator‐activated receptor‐gamma coactivator 1‐alpha) regulate oxidative stress response in…”
Get full text

Hypoxia and inflammation in human retinal cells by Arjamaa, O., Aaltonen, V., Piippo, N., Csont, T., Petrovski, G., Kaarniranta, K., Kauppinen, A.

“…Purpose Retina is extremely sensitive to low oxygen tension as its metabolic rate is the highest one among tissues. In diabetic macular edema, there always…”
Get full text

Autophagy stimulus affects different kinase pathways and promotes HuR protein activation and SQSTM1/p62 protein synthesis in ARPE‐19 cells by Amadio, M., Marchesi, N., Govoni, S., Pascale, A., Kaarniranta, K.

“…Purpose Age‐related macular degeneration (AMD) pathogenesis is characterized by protein degradation impairment in retinal pigment epithelial (RPE) cells. We…”
Get full text

cis‐Urocanic acid prevents inflammation and cell death in UVB‐treated ARPE‐19 cells by Korhonen, E., Piippo, N., Hytti, M., Kaarniranta, K., Kauppinen, A.

“…Purpose cis‐Urocanic acid (cis‐UCA) is an endogenous ultraviolet (UV) absorbing chromophore that is mainly produced in the upper layers of epidermis. The aim…”
Get full text