Search Results - "KA FAI TO"

Nasopharyngeal carcinoma: an evolving paradigm by Wong, Kenneth C. W., Hui, Edwin P., Lo, Kwok-Wai, Lam, Wai Kei Jacky, Johnson, David, Li, Lili, Tao, Qian, Chan, Kwan Chee Allen, To, Ka-Fai, King, Ann D., Ma, Brigette B. Y., Chan, Anthony T. C.

“…The past three decades have borne witness to many advances in the understanding of the molecular biology and treatment of nasopharyngeal carcinoma (NPC), an…”
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The role of Epstein-Barr virus in epithelial malignancies by Tsao, Sai-Wah, Tsang, Chi Man, To, Ka-Fai, Lo, Kwok-Wai

“…The close association of Epstein–Barr virus (EBV) infection with non‐keratinizing nasopharyngeal carcinomas and a subset of gastric carcinomas suggests that…”
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Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury by Wang, Ying-Ying, Jiang, Hong, Pan, Jun, Huang, Xiao-Ru, Wang, Yu-Cheng, Huang, Hong-Feng, To, Ka-Fai, Nikolic-Paterson, David J, Lan, Hui-Yao, Chen, Jiang-Hua

“…Interstitial fibrosis is an important contributor to graft loss in chronic renal allograft injury. Inflammatory macrophages are associated with fibrosis in…”
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Expanding the spectrum of tyrosine kinase fusions in calcified chondroid mesenchymal neoplasms: Identification of a novel PDGFRA::USP8 gene fusion by Fisher, Yael, Lacambra, Maribel D., Almohsen, Shahd S., Chow, Chit, Hornick, Jason L., To, Ka‐Fai, Dickson, Brendan C.

“…Calcified chondroid mesenchymal neoplasms represent a distinct, and recently recognized, spectrum of tumors. To date most cases have been reported to be…”
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Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis by Wang, Xiaojuan, Zhang, Xiang, Chu, Eagle S. H., Chen, Xiaoting, Kang, Wei, Wu, Feng, To, Ka‐Fai, Wong, Vincent W. S., Chan, Henry L. Y., Chan, Matthew T. V., Sung, Joseph J. Y., Wu, William K. K., Yu, Jun

“…Autophagic impairment is implicated in nonalcoholic fatty liver disease (NAFLD), but the molecular mechanism is unclear. We found that autophagic flux was…”
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TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment by Chung, Jeff Yat-Fai, Chan, Max Kam-Kwan, Li, Jane Siu-Fan, Chan, Alex Siu-Wing, Tang, Philip Chiu-Tsun, Leung, Kam-Tong, To, Ka-Fai, Lan, Hui-Yao, Tang, Patrick Ming-Kuen

“…Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic…”
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CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling by Tang, Kwan Ho, Ma, Stephanie, Lee, Terence K., Chan, Yuen Piu, Kwan, Pak Shing, Tong, Carol M., Ng, Irene O., Man, Kwan, To, Ka-Fai, Lai, Paul B., Lo, Chung-Mau, Guan, Xin-Yuan, Chan, Kwok Wah

“…A novel theory in the field of tumor biology postulates that cancer growth is driven by a population of stem‐like cells, called tumor‐initiating cells (TICs)…”
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Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non–Small-Cell Lung Cancer in Asia (IPASS) by FUKUOKA, Masahiro, WU, Yi-Long, DUFFIELD, Emma L, RUKAZENKOV, Yuri, SPEAKE, Georgina, HAIYI JIANG, ARMOUR, Alison A, TO, Ka-Fai, CHIH-HSIN YANG, James, MOK, Tony S. K, THONGPRASERT, Sumitra, SUNPAWERAVONG, Patrapim, LEONG, Swan-Swan, SRIURANPONG, Virote, CHAO, Tsu-Yi, NAKAGAWA, Kazuhiko, CHU, Da-Tong, SAIJO, Nagahiro

“…The results of the Iressa Pan-Asia Study (IPASS), which compared gefitinib and carboplatin/paclitaxel in previously untreated never-smokers and light…”
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Activation of sterol regulatory element‐binding protein 1 (SREBP1)‐mediated lipogenesis by the Epstein–Barr virus‐encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma by Lo, Angela Kwok‐Fung, Lung, Raymond Wai‐Ming, Dawson, Christopher W, Young, Lawrence S, Ko, Chuen‐Wai, Yeung, Walter Wai, Kang, Wei, To, Ka‐Fai, Lo, Kwok‐Wai

“…Nasopharyngeal carcinoma (NPC) is closely associated with Epstein–Barr virus (EBV) infection. The EBV‐encoded latent membrane protein 1 (LMP1), which is…”
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Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development by Tang, Patrick Ming-Kuen, Zhou, Shuang, Meng, Xiao-Ming, Wang, Qing-Ming, Li, Chun-Jie, Lian, Guang-Yu, Huang, Xiao-Ru, Tang, Yong-Jiang, Guan, Xin-Yuan, Yan, Bryan Ping-Yen, To, Ka-Fai, Lan, Hui-Yao

“…TGF-β is known to influence tumour progression. Here we report an additional role of Smad3 in the tumour microenvironment regulating cancer progression…”
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Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B by Chan, Anthony W H, Wong, Grace L H, Chan, Hoi-Yun, Tong, Joanna H M, Yu, Yau-Hei, Choi, Paul C L, Chan, Henry L Y, To, Ka-Fai, Wong, Vincent W S

“…Concurrent fatty liver in hepatitis B virus (HBV)-infected patients without significant alcohol intake is a frequent and increasingly alarming problem because…”
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The novel finding of an FGFR1::TACC1 fusion in an undifferentiated spindle cell sarcoma of soft tissue with aggressive clinical course by Yau, Derek Tsz‐Wai, Lacambra, Maribel D., Chow, Chit, To, Ka‐Fai

“…We report an aggressive soft tissue sarcoma with FGFR1‐TACC1 fusion occurring in the thigh of an 83‐year‐old man. Microscopically, the tumor was composed of…”
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Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition by Tang, Patrick Ming-Kuen, Zhang, Ying-ying, Xiao, Jun, Tang, Philip Chiu-Tsun, Chung, Jeff Yat-Fai, Li, Jinhong, Xue, Vivian Weiwen, Huang, Xiao-Ru, Chong, Charing Ching-Ning, Ng, Chi-Fai, Lee, Tin-Lap, To, Ka-Fai, Nikolic-Paterson, David J., Lan, Hui-Yao

“…Unresolved inflammation can lead to tissue fibrosis and impaired organ function. Macrophage–myofibroblast transition (MMT) is one newly identified mechanism by…”
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A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma by Yang, Weiqin, Feng, Yu, Zhou, Jingying, Cheung, Otto Ka-Wing, Cao, Jianquan, Wang, Jing, Tang, Wenshu, Tu, Yalin, Xu, Liangliang, Wu, Feng, Tan, Zhiwu, Sun, Hanyong, Tian, Yuan, Wong, John, Lai, Paul Bo-San, Chan, Stephen Lam, Chan, Anthony Wing-Hung, Tan, Patrick Boon-Ooi, Chen, Zhiwei, Sung, Joseph Jao-Yiu, Yip, Kevin Yuk-Lap, To, Ka-Fai, Cheng, Alfred Sze-Lok

“…Insufficient T cell infiltration into noninflamed tumors, such as hepatocellular carcinoma (HCC), restricts the effectiveness of immune-checkpoint blockade…”
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SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase‐3β/β‐catenin signaling by Chen, Juan, Chan, Anthony W.H., To, Ka‐Fai, Chen, Weixian, Zhang, Zhenzhen, Ren, Jihua, Song, Chunli, Cheung, Yue‐Sun, Lai, Paul B.S., Cheng, Suk‐Hang, Ng, Margaret H.L., Huang, Ailong, Ko, Ben C.B.

“…Sirtuin 1 (SIRT1) has been implicated in telomere maintenance and the growth of hepatocellular carcinoma (HCC). Nevertheless, the role of other sirtuins in the…”
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RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype by Cai, Demin, Wang, Junjian, Gao, Bei, Li, Jin, Wu, Feng, Zou, June X., Xu, Jianzhen, Jiang, Yuqian, Zou, Hongye, Huang, Zenghong, Borowsky, Alexander D., Bold, Richard J., Lara, Primo N., Li, Jian Jian, Chen, Xinbin, Lam, Kit S., To, Ka-Fai, Kung, Hsing-Jien, Fiehn, Oliver, Zhao, Ruqian, Evans, Ronald M., Chen, Hong-Wu

“…Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC)…”
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Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches by Lo, Kwok-Wai, Chung, Grace Tin-Yun, To, Ka-Fai

“…Abstract Nasopharyngeal carcinoma (NPC) is consistently associated with EBV infection and prevalence in southern China and Southeast Asia. In addition to EBV,…”
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New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score by Chan, Anthony W H, Chan, Ronald C K, Wong, Grace L H, Wong, Vincent W S, Choi, Paul C L, Chan, Henry L Y, To, Ka-Fai

“…Background and Aim Serum albumin and bilirubin are the most significant independent prognostic factors to predict hepatic events in patients with primary…”
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Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection by Chan, Anthony W. H., Chan, Stephen L., Wong, Grace L. H., Wong, Vincent W. S., Chong, Charing C. N., Lai, Paul B. S., Chan, Henry L. Y., To, Ka-Fai

“…Background Approximately one-quarter of patients with Barcelona Clinic Liver Cancer (BCLC) stage 0/A hepatocellular carcinoma (HCC) suffer from tumor relapse…”
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TGF-β signaling networks in the tumor microenvironment by Chan, Max Kam-Kwan, Chung, Jeff Yat-Fai, Tang, Philip Chiu-Tsun, Chan, Alex Siu-Wing, Ho, Johnny Yuk-Yeung, Lin, Tony Pak-Tik, Chen, Jiaoyi, Leung, Kam-Tong, To, Ka-Fai, Lan, Hui-Yao, Tang, Patrick Ming-Kuen

“…Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology and pathology, especially in the progression of inflammatory diseases…”
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