Folic acid grafted aminated zeolitic imidazolate framework (ZIF-8) as pH responsive drug carrier for targeted delivery of curcumin

Smart drug delivery systems responding to pH gradient between physiological conditions and acidic conditions in tumor cells are very crucial for treating cancer. This article describes the process of developing, zeolitic imidazolate framework (ZIF-8) based novel pH responsive drug carrier for the ta...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of drug delivery science and technology Vol. 79; p. 104098
Main Authors:	R., Reshmi, K.R., Jiju, S., Suma, Nair, Anoop S.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-01-2023
Subjects:	Curcumin Drug delivery systems Folic acid Zeolitic imidazolate framework-8(ZIF-8) Drug delivery systems Curcumin Zeolitic imidazolate framework-8(ZIF-8) Folic acid
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Smart drug delivery systems responding to pH gradient between physiological conditions and acidic conditions in tumor cells are very crucial for treating cancer. This article describes the process of developing, zeolitic imidazolate framework (ZIF-8) based novel pH responsive drug carrier for the targeted delivery of curcumin (CUR). To enable folic acid (FA) conjugation the surface of ZIF-8 was modified through amination. The so developed CUR loaded folic acid grafted aminated ZIF-8 (CUR@FA-g-AZIF-8) were characterized with UV–Visible, FT-IR, PXRD, SEM, TGA, TEM and BET analysis. It shows high drug loading efficiency and good chemical stability. In vitro drug release studies of CUR from folic acid grafted aminated ZIF-8 (FA-g- AZIF-8) shows three times higher efficiency in acidic pH (5) than in normal physiological conditions (pH 7.4). The potential cytotoxicity was evaluated by MTT assay on HeLa cells, CUR@FA-g-AZIF-8 shows 76.8% cytotoxicity. The results show that FA-g-AZIF-8 is a promising drug carrier for targeted drug delivery. Schematic representation of folate receptors mediated pH responsive drug delivery action for efficient anti-tumor therapy. [Display omitted] •Folic acid grafted aminated ZIF-8 (FA-g-AZIF-8) were synthesized as pH stimuli responsive drug carrier.•A high drug loading efficiency of 91.6% CUR was obtained.•FA-g-AZIF-8 shows three-fold higher drug release in the acid medium (pH 5) compared with physiological conditions (pH 7.4) and MTT studies on HeLa showed 76.8% cytotoxicity.
ISSN:	1773-2247
DOI:	10.1016/j.jddst.2022.104098