Search Results - "K. SAINI, NEERAJ"

Rhamnolipid the Glycolipid Biosurfactant: Emerging trends and promising strategies in the field of biotechnology and biomedicine by Thakur, Priyanka, Saini, Neeraj K, Thakur, Vijay Kumar, Gupta, Vijai Kumar, Saini, Reena V, Saini, Adesh K

“…Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa. Due to their…”
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Understanding the cross-talk between human microbiota and gastrointestinal cancer for developing potential diagnostic and prognostic biomarkers by Kashyap, Sheetal, Pal, Soumya, Chandan, Gourav, Saini, Vipin, Chakrabarti, Sasanka, Saini, Neeraj K., Mittal, Amit, Thakur, Vijay Kumar, Saini, Adesh K., Saini, Reena V.

“…The interaction between gut microbes and gastrointestinal (GI) tract carcinogenesis has always attracted researchers’ attention to identify therapeutic targets…”
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A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens by Arora, Pooja, Baena, Andres, Yu, Karl O.A., Saini, Neeraj K., Kharkwal, Shalu S., Goldberg, Michael F., Kunnath-Velayudhan, Shajo, Carreño, Leandro J., Venkataswamy, Manjunatha M., Kim, John, Lazar-Molnar, Eszter, Lauvau, Gregoire, Chang, Young-tae, Liu, Zheng, Bittman, Robert, Al-Shamkhani, Aymen, Cox, Liam R., Jervis, Peter J., Veerapen, Natacha, Besra, Gurdyal S., Porcelli, Steven A.

“…Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the…”
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Alteration in the expression of microRNA-21 regulated target genes: Role in breast cancer by THAKUR, PRIYANKA, V. SAINI, REENA, K. CHHILLAR, ANIL, K. SAINI, NEERAJ, KUMAR THAKUR, VIJAY, SINGH SIWAL, SAMARJEET, K. SAINI, ADESH

“…Breast cancer, also recognized as the principal cause of cancer-related deaths among women, is the second most familiar and prevalent form of cancer. New…”
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A curious case of cysteines in human peroxiredoxin I by Mohammad, Ashu, Saini, Reena V., Kumar, Rakesh, Sharma, Deepak, Saini, Neeraj K., Gupta, Arpit, Thakur, Priyanka, Winterbourn, Christine C., Saini, Adesh K.

“…Peroxiredoxins (Prxs) are antioxidant proteins that are involved in cellular defence against reactive oxygen species and reactive nitrogen species. Humans have…”
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Recent Advancements in the Technologies Detecting Food Spoiling Agents by Saini, Reena V, Vaid, Prachi, Saini, Neeraj K, Siwal, Samarjeet Singh, Gupta, Vijai Kumar, Thakur, Vijay Kumar, Saini, Adesh K

“…To match the current life-style, there is a huge demand and market for the processed food whose manufacturing requires multiple steps. The mounting demand…”
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Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients by Saini, Neeraj K, Gabani, Bhavesh B, Todmal, Umesh, Sulochana, Suresh P, Kiran, Vinay, Zainuddin, Mohd, Balaji, Narayanan, Polina, Sai B, Srinivas, Nuggehally R, Mullangi, Ramesh

“…Darolutamide is recently approved for the treatment of non-metastatic castrate resistance prostate cancer. Hitherto, no stereoselective pharmacokinetic data…”
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Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis by Saini, Adesh K., Sharma, Anil, Saini, Vipin, Chakrabarti, Sasanka, Saini, Neeraj K., Khatana, Chainika, Saini, Reena V.

“…Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of…”
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Lipopolysaccharide inhibits translation of iron chaperone PCBP1 to regulate inflammatory cytokine response in macrophage by Yadav, Sameeksha, Saini, Neeraj K, Kulshreshtha, Diksha, Mukhopadhyay, Chinmay K

“…Macrophages play a key role in maintaining systemic iron homeostasis and immunity. During pro-inflammatory stage macrophages retain iron due to the decrease of…”
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Identification of Autophagy-Inhibiting Factors of Mycobacterium tuberculosis by High-Throughput Loss-of-Function Screening by Strong, Emily J, Jurcic Smith, Kristen L, Saini, Neeraj K, Ng, Tony W, Porcelli, Steven A, Lee, Sunhee

“…The interaction of host cells with mycobacteria is complex and can lead to multiple outcomes ranging from bacterial clearance to progressive or latent…”
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Revisiting a protocol for extraction of mycobacterial lipids by Singh, Pooja, Sinha, Rajesh, Tandon, Rashmi, Tyagi, Gaurav, Khatri, Preeti, Chandra Shekhar Reddy, L, Saini, Neeraj K, Pathak, Rakesh, Varma-Basil, Mandira, Prasad, Ashok K, Bose, Mridula

“…Abstract Determination of lipid content of any biological sample is essential for various kinds of studies related to pathogenicity and drug development. Thus,…”
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PDIM and SL1 accumulation in Mycobacterium tuberculosis is associated with mce4A expression by Singh, Pooja, Sinha, Rajesh, Tyagi, Gaurav, Sharma, Naresh Kumar, Saini, Neeraj K., Chandolia, Amita, Prasad, Ashok Kumar, Varma-Basil, Mandira, Bose, Mridula

“…Lipid metabolism forms the heart and soul of Mycobacterium tuberculosis life cycle. Starting from macrophage invasion at cholesterol rich micro-domains to a…”
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Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis by Goldberg, Michael F, Saini, Neeraj K, Porcelli, Steven A

“…Through thousands of years of reciprocal coevolution, Mycobacterium tuberculosis has become one of humanity's most successful pathogens, acquiring the ability…”
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Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47 by Saini, Neeraj K., Baena, Andres, Ng, Tony W., Venkataswamy, Manjunatha M., Kennedy, Steven C., Kunnath-Velayudhan, Shajo, Carreño, Leandro J., Xu, Jiayong, Chan, John, Larsen, Michelle H., Jacobs, William R., Porcelli, Steven A.

“…Suppression of major histocompatibility complex (MHC) class II antigen presentation is believed to be among the major mechanisms used by Mycobacterium…”
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Amide-Linked C4″-Saccharide Modification of KRN7000 Provides Potent Stimulation of Human Invariant NKT Cells and Anti-Tumor Immunity in a Humanized Mouse Model by Saavedra-Avila, Noemi Alejandra, Keshipeddy, Santosh, Guberman-Pfeffer, Matthew J, Pérez-Gallegos, Ayax, Saini, Neeraj K, Schäfer, Carolina, Carreño, Leandro J, Gascón, José A, Porcelli, Steven A, Howell, Amy R

“…Activation of invariant natural killer T (iNKT) cells by α-galactosylceramides (α-GalCers) stimulates strong immune responses and potent anti-tumor immunity…”
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Transcriptome Analysis of Mycobacteria-Specific CD4 + T Cells Identified by Activation-Induced Expression of CD154 by Kunnath-Velayudhan, Shajo, Goldberg, Michael F, Saini, Neeraj K, Johndrow, Christopher T, Ng, Tony W, Johnson, Alison J, Xu, Jiayong, Chan, John, Jacobs, Jr, William R, Porcelli, Steven A

“…Analysis of Ag-specific CD4 T cells in mycobacterial infections at the transcriptome level is informative but technically challenging. Although several methods…”
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Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4 + T Cells by Johnson, Alison J, Kennedy, Steven C, Lindestam Arlehamn, Cecilia S, Goldberg, Michael F, Saini, Neeraj K, Xu, Jiayong, Paul, Sinu, Hegde, Subray S, Blanchard, John S, Chan, John, Jacobs, Jr, William R, Sette, Alessandro, Porcelli, Steven A

“…Tuberculosis (TB) due to remains a major global infectious disease problem, and a more efficacious vaccine is urgently needed for the control and prevention of…”
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Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival by Sinha, Rajesh, Singh, Pooja, Saini, Neeraj k, Kumar, Ajit, Pathak, Rakesh, Chandolia, Amita, Garima, Kushal, Tyagi, Gaurav, Chopra, Madhu, Prasad, Ashok Kumar, Raj, Hanumantharao G., Bose, Mridula

“…Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host…”
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The Mycobacterium tuberculosis recombinant LprN protein of mce4 operon induces Th-1 type response deleterious to protection in mice by Pasricha, Rashmi, Saini, Neeraj K., Rathor, Nisha, Pathak, Rakesh, Sinha, Rajesh, Varma-Basil, Mandira, Mishra, Kiran, Brahmachari, Vani, Bose, Mridula

“…Abstract Lipoproteins are known to be effective immunogens and affect both innate and adaptive immunity. The lprN gene of Mycobacterium tuberculosis has been…”
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Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes by Arora, Pooja, Kharkwal, Shalu S., Ng, Tony W., Kunnath-Velayudhan, Shajo, Saini, Neeraj K., Johndrow, Christopher T., Chang, Young-tae, Besra, Gurdyal S., Porcelli, Steven A.

“…[Display omitted] •Neutralization of endosomal pH increases presentation of Th2-biasing αGC analogues, and their association with CD1d in cholesterol rich…”
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