Search Results - "K. Ravala, Sandeep"

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG

“…PIP 3 -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
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Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold by Cash, Jennifer N, Urata, Sarah, Li, Sheng, Ravala, Sandeep K, Avramova, Larisa V, Shost, Michael D, Gutkind, J Silvio, Tesmer, John J G, Cianfrocco, Michael A

“…PIP -dependent Rac exchanger 1 (P-Rex1) is activated downstream of G protein-coupled receptors to promote neutrophil migration and metastasis. The structure of…”
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New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors by Ravala, Sandeep K, Tesmer, John J G

“…Transmembrane signaling is a critical process by which changes in the extracellular environment are relayed to intracellular systems that induce changes in…”
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Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ by Chen, Chun-Liang, Syahirah, Ramizah, Ravala, Sandeep K., Yen, Yu-Chen, Klose, Thomas, Deng, Qing, Tesmer, John J. G.

“…The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-kinase γ (PI3Kγ) is critical for…”
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Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1 by Bandekar, Sumit J., Chen, Chun-Liang, Ravala, Sandeep K., Cash, Jennifer N., Avramova, Larisa V., Zhalnina, Mariya V., Gutkind, J. Silvio, Li, Sheng, Tesmer, John J.G.

“…Trio is a large and highly conserved metazoan signaling scaffold that contains two Dbl family guanine nucleotide exchange factor (GEF) modules, TrioN and…”
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The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding by Ravala, Sandeep K., Hopkins, Jesse B., Plescia, Caroline B., Allgood, Samantha R., Kane, Madison A., Cash, Jennifer N., Stahelin, Robert V., Tesmer, John J.G.

“…Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) catalyzes the exchange of GDP for GTP on Rac GTPases, thereby triggering…”
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Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic‐type serine/threonine kinase from Mycobacterium tuberculosis by Ravala, Sandeep K, Singh, Suruchi, Yadav, Ghanshyam S, Kumar, Sanjay, Karthikeyan, Subramanian, Chakraborti, Pradip K

“…Phosphorylation of the activation loop in the catalytic domain of the RD family of bacterial eukaryotic‐type Ser/Thr protein kinases (STPK) induces their…”
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Eukaryotic-type serine/threonine kinase mediated phosphorylation at Thr169 perturbs mycobacterial guanylate kinase activity by S. Yadav, Ghanshyam, K. Ravala, Sandeep, Kachhap, Sangita, Thakur, Meghna, Roy, Abhishek, Singh, Balvinder, Karthikeyan, Subramanian, K. Chakraborti, Pradip

“…Guanylate kinase is an essential and conserved enzyme in nucleotide biosynthetic pathway that transfers phosphoryl group of ATP to GMP for yielding GDP. Here,…”
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Phosphorylation Modulates Catalytic Activity of Mycobacterial Sirtuins by Yadav, Ghanshyam S, Ravala, Sandeep K, Malhotra, Neha, Chakraborti, Pradip K

“…Sirtuins are NAD(+)-dependent deacetylases involved in the regulation of diverse cellular processes and are conserved throughout phylogeny. Here we report…”
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Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG

“…PIP 3 -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
Get full text

Structural and dynamic changes in P-Rex1 upon activation by PIP 3 and inhibition by IP 4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John J G

“…PIP -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
Get full text

Evidence for the interplay between post‐translational modifications in regulating mycobacterial sirtuin activity by Yadav, Ghanshyam Singh, Ravala, Sandeep K, Malhotra, Neha, Chakraborti, Pradip K

“…Abstract only Regulation of cellular processes by post‐translational modification of proteins is well known throughout the phylogeny…”
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Eukaryotic-type serine/threonine kinase mediated phosphorylation at Thr 169 perturbs mycobacterial guanylate kinase activity by S Yadav, Ghanshyam, K Ravala, Sandeep, Kachhap, Sangita, Thakur, Meghna, Roy, Abhishek, Singh, Balvinder, Karthikeyan, Subramanian, K Chakraborti, Pradip

“…Guanylate kinase is an essential and conserved enzyme in nucleotide biosynthetic pathway that transfers phosphoryl group of ATP to GMP for yielding GDP. Here,…”
Get full text