Search Results - "K. Holien, Jessica"

Oncogenic protein interfaces: small molecules, big challenges by Nero, Tracy L., Morton, Craig J., Holien, Jessica K., Wielens, Jerome, Parker, Michael W.

“…Key Points More than 300,000 interaction pairs have already been identified in the human genome; therefore, modulating protein–protein interactions (PPIs) has…”
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Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation by HURT, Aeron C, HOLIEN, Jessica K, PARKER, Michael, KELSO, Anne, BARR, Ian G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster by Perry, Trent, Chen, Wei, Ghazali, Razi, Yang, Ying Ting, Christesen, Danielle, Martelli, Felipe, Lumb, Chris, Bao Luong, Hang Ngoc, Mitchell, Judith, Holien, Jessica K., Parker, Michael W., Sparks, Thomas C., Batterham, Philip

“…Insecticides remain valuable tools for the control of insect pests that significantly impact human health and agriculture. A deeper understanding of…”
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Mitochondrial fission – a drug target for cytoprotection or cytodestruction? by Rosdah, Ayeshah A., K. Holien, Jessica, Delbridge, Lea M. D., Dusting, Gregory J., Lim, Shiang Y.

“…Mitochondria are morphologically dynamic organelles constantly undergoing processes of fission and fusion that maintain integrity and bioenergetics of the…”
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Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission by Kalkhoran, Siavash Beikoghli, Kriston-Vizi, Janos, Hernandez-Resendiz, Sauri, Crespo-Avilan, Gustavo E, Rosdah, Ayeshah A, Lees, Jarmon G, Costa, Joana Rodrigues Simoes Da, Ling, Naomi X Y, Holien, Jessica K, Samangouei, Parisa, Chinda, Kroekkiat, Yap, En Ping, Riquelme, Jaime A, Ketteler, Robin, Yellon, Derek M, Lim, Shiang Y, Hausenloy, Derek J

“…Abstract Aims Genetic and pharmacological inhibition of mitochondrial fission induced by acute myocardial ischaemia/reperfusion injury (IRI) has been shown to…”
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A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution by Paudel, Bishnu P, Moye, Aaron Lavel, Abou Assi, Hala, El-Khoury, Roberto, Cohen, Scott B, Holien, Jessica K, Birrento, Monica L, Samosorn, Siritron, Intharapichai, Kamthorn, Tomlinson, Christopher G, Teulade-Fichou, Marie-Paule, González, Carlos, Beck, Jennifer L, Damha, Masad J, van Oijen, Antoine M, Bryan, Tracy M

“…Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres, preventing their extension by the ribonucleoprotein telomerase…”
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A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma by Cheung, Belamy B., Kleynhans, Ane, Mittra, Rituparna, Kim, Patrick Y., Holien, Jessica K., Nagy, Zsuzsanna, Ciampa, Olivia C., Seneviratne, Janith A., Mayoh, Chelsea, Raipuria, Mukesh, Gadde, Satyanarayana, Massudi, Hassina, Wong, Iris Poh Ling, Tan, Owen, Gong, Andrew, Suryano, Aldwin, Diakiw, Sonya M., Liu, Bing, Arndt, Greg M., Liu, Tao, Kumar, Naresh, Sangfelt, Olle, Zhu, Shizhen, Norris, Murray D., Haber, Michelle, Carter, Daniel R., Parker, Michael W., Marshall, Glenn M.

“…Histone deacetylase (HDAC) inhibitors are effective in MYCN-driven cancers, because of a unique need for HDAC recruitment by the MYCN oncogenic signal…”
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A novel small molecule inhibitor of human Drp1 by Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.

“…Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous…”
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In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses by HURT, Aeron C, HOLIEN, Jessica K, BARR, Ian G

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma by Bell, Jessica L, Hagemann, Sven, Holien, Jessica K, Liu, Tao, Nagy, Zsuzsanna, Schulte, Johannes H, Misiak, Danny, Hüttelmaier, Stefan

“…Neuroblastoma is a common childhood cancer with almost a third of those affected still dying, thus new therapeutic strategies need to be explored. Current…”
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Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability by Hodson, Charlotte, Low, Jason K K, van Twest, Sylvie, Jones, Samuel E, Swuec, Paolo, Murphy, Vincent, Tsukada, Kaima, Fawkes, Matthew, Bythell-Douglas, Rohan, Davies, Adelina, Holien, Jessica K, O'Rourke, Julienne J, Parker, Benjamin L, Glaser, Astrid, Parker, Michael W, Mackay, Joel P, Blackford, Andrew N, Costa, Alessandro, Deans, Andrew J

“…The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome complex") for dissolution of…”
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Structural Analysis of the Complex of Human Transthyretin with 3′,5′-Dichlorophenylanthranilic Acid at 1.5 Å Resolution by Cody, Vivian, Truong, Jia Q, Holdsworth, Bruce A, Holien, Jessica K, Richardson, Samantha J, Chalmers, David K, Craik, David J

“…Human transthyretin (hTTR) can form amyloid deposits that accumulate in nerves and organs, disrupting cellular function. Molecules such as tafamidis that bind…”
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A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility by Boer, Jennifer C, Pan, Qisheng, Holien, Jessica K, Nguyen, Thanh-Binh, Ascher, David B, Plebanski, Magdalena

“…COVID-19 pandemic has been threatening public health and economic development worldwide for over two years. Compared with the original SARS-CoV-2 strain…”
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TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members by Bell, Jessica L, Malyukova, Alena, Holien, Jessica K, Koach, Jessica, Parker, Michael W, Kavallaris, Maria, Marshall, Glenn M, Cheung, Belamy B

“…The TRIM family of proteins is distinguished by its tripartite motif (TRIM). Typically, TRIM proteins contain a RING finger domain, one or two B-box domains, a…”
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Oseltamivir Resistance and the H274Y Neuraminidase Mutation in Seasonal, Pandemic and Highly Pathogenic Influenza Viruses by Hurt, Aeron C., Holien, Jessica K., Parker, Michael W., Barr, Ian G.

“…Along with influenza vaccines, the world is currently almost completely dependent on two licensed drugs for the treatment or prevention of seasonal (influenza…”
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Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity by Feil, Susanne C., Lawrence, Sara, Mulhern, Terrence D., Holien, Jessica K., Hotze, Eileen M., Farrand, Stephen, Tweten, Rodney K., Parker, Michael W.

“…The cholesterol-dependent cytolysins (CDCs) punch holes in target cell membranes through a highly regulated process. Streptococcus mitis lectinolysin (LLY)…”
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Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1) by Simonov, Alexandr N, Holien, Jessica K, Yeung, Joyee Chun In, Nguyen, Ann D, Corbin, C Jo, Zheng, Jie, Kuznetsov, Vladimir L, Auchus, Richard J, Conley, Alan J, Bond, Alan M, Parker, Michael W, Rodgers, Raymond J, Martin, Lisandra L

“…Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer…”
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A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma by Craig, Olivia, Lee, Samuel, Pilcher, Courtney, Saoud, Rita, Abdirahman, Suad, Salazar, Carolina, Williams, Nathan, Ascher, David B, Vary, Robert, Luu, Jennii, Cowley, Karla J, Ramm, Susanne, Li, Mark Xiang, Thio, Niko, Li, Jason, Semple, Tim, Simpson, Kaylene J, Gorringe, Kylie L, Holien, Jessica K

“…Abstract Mucinous ovarian carcinoma (MOC) is a subtype of ovarian cancer that is distinct from all other ovarian cancer subtypes and currently has no targeted…”
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A Homodimer Model Can Resolve the Conundrum as to How Cytochrome P450 Oxidoreductase and Cytochrome b5 Compete for the Same Binding Site on Cytochrome P450c17 by Holien, Jessica K, Parker, Michael W, Conley, Alan J, Corbin, Cynthia Jo, Rodgers, Raymond J, Martin, Lisandra L

“…Cytochrome P450 17α-hydroxylase, 17,20-lyase (P450c17) is a key enzyme in the synthesis of cortisol in the zona fascicula of the adrenal cortex, and the…”
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Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding by Tomlinson, Christopher G, Moye, Aaron L, Holien, Jessica K, Parker, Michael W, Cohen, Scott B, Bryan, Tracy M

“…The ribonucleoprotein enzyme telomerase maintains telomeres and is essential for cellular immortality in most cancers. Insight into the telomerase mechanism…”
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