Search Results - "K. Ally"
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Optimization of hydrogen-deuterium exchange ensemble reweighting (HDXer) to aid the biophysical characterization of proteins
Published in Biophysical journal (10-02-2023)Get full text
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Estimated Effects of Different Alcohol Taxation and Price Policies on Health Inequalities: A Mathematical Modelling Study
Published in PLoS medicine (01-02-2016)“…While evidence that alcohol pricing policies reduce alcohol-related health harm is robust, and alcohol taxation increases are a WHO "best buy" intervention,…”
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Integration of Hydrogen–Deuterium Exchange Mass Spectrometry with Molecular Dynamics Simulations and Ensemble Reweighting Enables High Resolution Protein–Ligand Modeling
Published in Journal of the American Society for Mass Spectrometry (06-11-2024)“…Hydrogen–Deuterium exchange mass spectrometry’s (HDX-MS) utility in identifying and characterizing protein–small molecule interaction sites has been…”
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Infanticide by Females Is a Leading Source of Juvenile Mortality in a Large Social Carnivore
Published in The American naturalist (01-11-2021)“…AbstractSocial animals benefit from their groupmates, so why do they sometimes kill each other's offspring? Using 30 years of data from multiple groups of wild…”
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Seed mix design and floral resources drive multitrophic interactions in prairie restoration
Published in The Journal of applied ecology (01-04-2024)“…Abstract Ecological restoration often targets plant community recovery, but restoration success may depend on the recovery of a complex web of biotic…”
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The adverse health effects and harms related to marijuana use: an overview review
Published in CMAJ open (01-07-2018)“…With impending marijuana legislation in Canada, a broad understanding of the harms associated with marijuana use is needed to inform the clinical community and…”
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The impact of pharmaceutical rebates on patients’ drug expenditures
Published in Canadian Medical Association journal (CMAJ) (18-03-2019)“…Memedovich et al discuss the impact of pharmaceutical rebates on patients' drug expenditures. Among other things, the most common practices within…”
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Modeling the native ensemble of PhuS using enhanced sampling MD and HDX-ensemble reweighting
Published in Biophysical journal (07-12-2021)“…The cytoplasmic heme binding protein from Pseudomonas aeruginosa, PhuS, plays two essential roles in regulating heme uptake and iron homeostasis. First, PhuS…”
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Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling
Published in Cell reports (Cambridge) (28-05-2024)“…Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive…”
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Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase‑2 (LH2) Inhibition
Published in Journal of chemical information and modeling (13-02-2023)“…The catalytic function of lysyl hydroxylase-2 (LH2), a member of the Fe(II)/αKG-dependent oxygenase superfamily, is to catalyze the hydroxylation of lysine to…”
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Projected Healthcare System Cost Burden of Metabolic Dysfunction-Associated Steatotic Liver Disease in Canada
Published in Gastro hep advances (2024)“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease worldwide. The current and projected cost of…”
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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts
Published in Journal of thrombosis and haemostasis (01-10-2022)“…Deficiency in blood coagulation factor VIII (FVIII) results in life‐threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve…”
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Emerging wild virus of native grass bioenergy feedstock is well‐established in the Midwestern USA and associated with premature stand senescence
Published in Global change biology. Bioenergy (01-04-2022)“…The North American native prairie grass Panicum virgatum (switchgrass) is a primary bioenergy feedstock candidate. Its widespread distribution and genetic…”
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Factors affecting compliance with infection prevention and control standard precautions among healthcare workers in Songwe region, Tanzania
Published in Infection prevention in practice (01-12-2022)“…Compliance with infection prevention and control standard precautions (IPCSPs) remains a major challenge in many countries including Tanzania. Lack of…”
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Effect of feeding complete diets containing spent cumin (Cuminum cyminum) seeds on serum biochemical parameters of Malabari kids
Published in Journal of Veterinary and Animal Sciences (01-06-2023)“…A feeding trial of three months was conducted in goat kids to study the effect of feeding complete diets containing spent cumin (Cuminum cyminum) seeds on…”
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Metagenomic analysis exploring taxonomic diversity of rumen microbial communities in Vechur and crossbred cattle of Kerala state, India
Published in Journal of applied genetics (01-05-2020)“…Rumen, one of the most productive diverse microbial habitats plays a vital role in the breakdown of feed to produce energy for maintenance and milk production…”
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Butterfly Abundance and Diversity in Different Habitat Types in the Usangu Area, Ruaha National Park
Published in Psyche (Cambridge, Mass.) (28-02-2024)“…Insects are key fauna species that respond quickly to disturbances and environmental changes. They act as good indicators of habitat, community, or ecosystem…”
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