Search Results - "K. Williamson, Andrew J"

Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia by Alanazi, Bader, Munje, Chinmay R., Rastogi, Namrata, Williamson, Andrew J. K., Taylor, Samuel, Hole, Paul S., Hodges, Marie, Doyle, Michelle, Baker, Sarah, Gilkes, Amanda F., Knapper, Steven, Pierce, Andrew, Whetton, Anthony D., Darley, Richard L., Tonks, Alex

“…Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the…”
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Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells by Abraham, Sheela A., Hopcroft, Lisa E. M., Carrick, Emma, Drotar, Mark E., Dunn, Karen, Williamson, Andrew J. K., Korfi, Koorosh, Baquero, Pablo, Park, Laura E., Scott, Mary T., Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M., Vetrie, David, Whetton, Anthony D., Holyoake, Tessa L.

“…Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of…”
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Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells by Bulut-Karslioglu, Aydan, Jin, Hu, Kim, Yun-Kyo, Cho, Brandon, Guzman-Ayala, Marcela, Williamson, Andrew J. K., Hejna, Miroslav, Stötzel, Maximilian, Whetton, Anthony D., Song, Jun S., Ramalho-Santos, Miguel

“…Stem and progenitor cells undergo a global elevation of nascent transcription, or hypertranscription, during key developmental transitions involving rapid cell…”
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BCR-ABL affects STAT5A and STAT5B differentially by Schaller-Schönitz, Michael, Barzan, David, Williamson, Andrew J K, Griffiths, John R, Dallmann, Iris, Battmer, Karin, Ganser, Arnold, Whetton, Anthony D, Scherr, Michaela, Eder, Matthias

“…Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene…”
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Characterization and Sequence Mapping of Large RNA and mRNA Therapeutics Using Mass Spectrometry by Vanhinsbergh, Christina J., Criscuolo, Angela, Sutton, Jennifer N., Murphy, Keeley, Williamson, Andrew J. K., Cook, Ken, Dickman, Mark J.

“…Large RNA including mRNA (mRNA) has emerged as an important new class of therapeutics. Recently, this has been demonstrated by two highly efficacious vaccines…”
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Quantitative Proteomics Analysis Demonstrates Post-transcriptional Regulation of Embryonic Stem Cell Differentiation to Hematopoiesis by Williamson, Andrew J.K., Smith, Duncan L., Blinco, David, Unwin, Richard D., Pearson, Stella, Wilson, Claire, Miller, Crispin, Lancashire, Lee, Lacaud, Georges, Kouskoff, Valerie, Whetton, Anthony D.

“…Embryonic stem (ES) cells can differentiate in vitro to produce the endothelial and hematopoietic precursor, the hemangioblasts, which are derived from the…”
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HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block by Maiques-Diaz, Alba, Nicosia, Luciano, Basma, Naseer J., Romero-Camarero, Isabel, Camera, Francesco, Spencer, Gary J., Amaral, Fabio M. R., Simeoni, Fabrizio, Wingelhofer, Bettina, Williamson, Andrew J. K., Pierce, Andrew, Whetton, Anthony D., Somervaille, Tim C. P.

“…Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene…”
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Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy by Matthews, Laura C., Berry, Andrew A., Morgan, David J., Poolman, Toryn M., Bauer, Kerstin, Kramer, Frederike, Spiller, David G., Richardson, Rachel V., Chapman, Karen E., Farrow, Stuart N., Norman, Michael R., Williamson, Andrew J. K., Whetton, Anthony D., Taylor, Stephen S., Tuckermann, Jan P., White, Michael R. H., Ray, David W.

“…The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily, which controls programs regulating cell proliferation, differentiation, and…”
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Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling by Lee, Dung-Fang, Su, Jie, Ang, Yen-Sin, Carvajal-Vergara, Xonia, Mulero-Navarro, Sonia, Pereira, Carlos F., Gingold, Julian, Wang, Hung-Liang, Zhao, Ruiying, Sevilla, Ana, Darr, Henia, Williamson, Andrew J.K., Chang, Betty, Niu, Xiaohong, Aguilo, Francesca, Flores, Elsa R., Sher, Yuh-Pyng, Hung, Mien-Chie, Whetton, Anthony D., Gelb, Bruce D., Moore, Kateri A., Snoeck, Hans-Willem, Ma’ayan, Avi, Schaniel, Christoph, Lemischka, Ihor R.

“…Many signals must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC)…”
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BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response by Griaud, François, Williamson, Andrew J.K., Taylor, Samuel, Potier, David N., Spooncer, Elaine, Pierce, Andrew, Whetton, Anthony D.

“…BCR/ABL expression is the key characteristic of chronic myeloid leukaemia (CML). The progression of CML is associated with genomic instability. Systematic…”
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Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production by Morgan, David J., Poolman, Toryn M., Williamson, Andrew J. K., Wang, Zichen, Clark, Neil R., Ma’ayan, Avi, Whetton, Anthony D., Brass, Andrew, Matthews, Laura C., Ray, David W.

“…The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly conserved minor splice variant, GRγ, which differs by a single…”
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The time is right: proteome biology of stem cells by Whetton, Anthony D, Williamson, Andrew J K, Krijgsveld, Jeroen, Lee, Bong Hee, Lemischka, Ihor, Oh, Steve, Pera, Martin, Mummery, Christine, Heck, Albert J R

“…In stem cell biology, there is a growing need for advanced technologies that may help to unravel the molecular mechanisms of self-renewal and differentiation…”
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Protein Z: A putative novel biomarker for early detection of ovarian cancer by Russell, Matthew R., Walker, Michael J., Williamson, Andrew J. K., Gentry‐Maharaj, Aleksandra, Ryan, Andy, Kalsi, Jatinderpal, Skates, Steven, D'Amato, Alfonsina, Dive, Caroline, Pernemalm, Maria, Humphryes, Phillip C., Fourkala, Evangelia‐Ourania, Whetton, Anthony D., Menon, Usha, Jacobs, Ian, Graham, Robert L.J.

“…Ovarian cancer (OC) has the highest mortality of all gynaecological cancers. Early diagnosis offers an approach to achieving better outcomes. We conducted a…”
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EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association by Paredes, Roberto, Schneider, Marion, Stevens, Adam, White, Daniel J, Williamson, Andrew J K, Muter, Joanne, Pearson, Stella, Kelly, James R, Connors, Kathleen, Wiseman, Daniel H, Chadwick, John A, Löffler, Harald, Teng, Hsiang Ying, Lovell, Simon, Unwin, Richard, van de Vrugt, Henri J, Smith, Helen, Kustikova, Olga, Schambach, Axel, Somervaille, Tim C P, Pierce, Andrew, Whetton, Anthony D, Meyer, Stefan

“…Abstract The transcriptional regulator EVI1 has an essential role in early hematopoiesis and development. However, aberrantly high expression of EVI1 has…”
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The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer by Jangani, Maryam, Poolman, Toryn M., Matthews, Laura, Yang, Nan, Farrow, Stuart N., Berry, Andrew, Hanley, Neil, Williamson, Andrew J.K., Whetton, Anthony D., Donn, Rachelle, Ray, David W.

“…Glucocorticoids (GC) regulate cell fate and immune function. We identified the metastasis-promoting methyltransferase, metastasis-related methyltransferase 1…”
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A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data by Zhou, Cong, Walker, Michael J, Williamson, Andrew J K, Pierce, Andrew, Berzuini, Carlo, Dive, Caroline, Whetton, Anthony D

“…Isobaric tag for relative and absolute quantitation (iTRAQ) is a widely used method in quantitative proteomics. A robust data analysis strategy is required to…”
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EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association by Paredes, Roberto, Schneider, Marion, Stevens, Adam, White, Daniel J, K. Williamson, Andrew J, Muter, Joanne, Pearson, Stella, Kelly, James R, Connors, Kathleen, Wiseman, Daniel H, Chadwick, John A, Löffler, Harald, Teng, Hsiang Ying, Lovell, Simon, Unwin, Richard, van de Vrugt, Henri J, Smith, Helen, Kustikova, Olga, Schambach, Axel, P. Somervaille, Tim C, Pierce, Andrew, Whetton, Anthony D, Meyer, Stefan

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The requirement for proteomics to unravel stem cell regulatory mechanisms by Williamson, Andrew J.K., Whetton, Anthony D.

“…Stem cells are defined by their ability to self‐renew and to differentiate, the processes whereby these events are achieved is the subject of much…”
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MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5 by Whetton, Anthony D, Azmi, Norhaida Che, Pearson, Stella, Jaworska, Ewa, Zhang, Liqun, Blance, Rognvald, Kendall, Alexandra C, Nicolaou, Anna, Taylor, Samuel, Williamson, Andrew J K, Pierce, Andrew

“…The thrombopoietin receptor (MPL) has been shown to be mutated (MPL W515L) in myelofibrosis and thrombocytosis yet new approaches to treat this disorder are…”
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Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids by Dutta, Anindita, Potier, David N, Walker, Michael J, Gray, Oliver J, Parker, Catriona, Holland, Mark, Williamson, Andrew J K, Pierce, Andrew, Unwin, Richard D, Krishnan, Shekhar, Saha, Vaskar, Whetton, Anthony D

“…Cancer Biomarkers have the capability to improve patient outcomes. They have potential applications in diagnosis, prognosis, monitoring of disease progression…”
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