Correlation of HER 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma

The purpose of this study was to determine relationship between HER-2/neu status and estrogen receptor, progesterone receptor, grade and age by comparing fluorescence in situ hybridization and immunohistochemistry. One hundred invasive breast carcinomas were reviewed and fluorescence in situ hybridi...

Full description

Saved in:

Bibliographic Details
Published in:	Türk patoloji dergisi Vol. 27; no. 3; p. 196
Main Authors:	Ramadan, Saime Sezgın, Yapicier, Ozlem, Kıhtır, Selçuk, Erdemır, Ayhan, Doğan, Tuğser Hakan, Uskent, Ismail, Onat, Haluk, Cakmakçi, Metin
Format:	Journal Article
Language:	English
Published:	Turkey 2011
Subjects:	Adult Age Factors Biomarkers, Tumor - analysis Breast Neoplasms - chemistry Breast Neoplasms - diagnosis Breast Neoplasms - genetics Carcinoma - chemistry Carcinoma - diagnosis Carcinoma - genetics Chi-Square Distribution Female Gene Amplification Humans Immunohistochemistry In Situ Hybridization, Fluorescence Logistic Models Middle Aged Neoplasm Grading Neoplasm Invasiveness Odds Ratio Predictive Value of Tests Prognosis Receptor, ErbB-2 - genetics Receptors, Estrogen - analysis Receptors, Progesterone - analysis Risk Assessment Risk Factors Turkey Turkey
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The purpose of this study was to determine relationship between HER-2/neu status and estrogen receptor, progesterone receptor, grade and age by comparing fluorescence in situ hybridization and immunohistochemistry. One hundred invasive breast carcinomas were reviewed and fluorescence in situ hybridization analysis was performed in all cases. Immunohistochemical scores showed a perfect concordance with fluorescence in situ hybridization amplification ratios (p < 0.0001). The results indicated a significant correlation between HER-2/neu and grade, but an inverse relationship between HER-2/neu and hormone receptors. In women aged ≤ 45 years, an inverse relationship between HER-2/neu and progesterone receptor was found and no association was noted between HER-2/neu and other factors. In women aged > 45 years, the results indicated a significant correlation between HER-2/neu and grade, and there was an inverse relationship between HER-2/neu and hormone receptors.
ISSN:	1018-5615 1309-5730
DOI:	10.5146/tjpath.2011.01075