Search Results - "Kędzierski, Jacek"

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  1. 1

    Remote 1,5-Stereoselectivity Control by an N‑Ligand Switch in the Pd(0)/InI-Promoted Reactions of 4‑Ethynyl-β-lactams with Aldehydes by Domin, Sylwia, Kędzierski, Jacek, Zambroń, Bartosz K

    Published in Organic letters (07-06-2019)
    “…Configurationally stable ε-amido-propargylindiums, generated in situ from N-Ts-4-ethynylazetidin-2-ones in the presence of InI, catalytic amounts of…”
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    Journal Article
  2. 2

    Virtual screening and biological evaluation to identify pharmaceuticals potentially causing hypertension and hypokalemia by inhibiting steroid 11β-hydroxylase by Jäger, Marie-Christin, Kędzierski, Jacek, Gell, Victoria, Wey, Tim, Kollár, Jakub, Winter, Denise V., Schuster, Daniela, Smieško, Martin, Odermatt, Alex

    Published in Toxicology and applied pharmacology (15-09-2023)
    “…Several drugs were found after their market approval to unexpectedly inhibit adrenal 11β-hydroxylase (CYP11B1)-dependent cortisol synthesis. Known side-effects…”
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    Journal Article
  3. 3

    Activation of retinoic acid-related orphan receptor γ(t) by parabens and benzophenone UV-filters by Inderbinen, Silvia G., Kley, Manuel, Zogg, Michael, Sellner, Manuel, Fischer, André, Kędzierski, Jacek, Boudon, Stéphanie, Jetten, Anton M., Smieško, Martin, Odermatt, Alex

    Published in Toxicology (Amsterdam) (15-04-2022)
    “…Retinoic acid-related orphan receptor γt (RORγt) regulates immune responses and its impaired function contributes to inflammatory and autoimmune diseases and…”
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    Journal Article
  4. 4

    Assessment of the inhibitory potential of anabolic steroids towards human AKR1D1 by computational methods and in vitro evaluation by Kędzierski, Jacek, Allard, Julien A., Odermatt, Alex, Smieško, Martin

    Published in Toxicology letters (01-08-2023)
    “…Exposure to xenobiotics can adversely affect biochemical reactions, including hepatic bile acid synthesis. Bile acids are essential for dissolving lipophilic…”
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    Journal Article
  5. 5

    In silico and in vitro assessment of drugs potentially causing adverse effects by inhibiting CYP17A1 by Kędzierski, Jacek, Jäger, Marie-Christin, Naeem, Sadaf, Odermatt, Alex, Smieško, Martin

    Published in Toxicology and applied pharmacology (01-05-2024)
    “…Cytochrome P450 enzymes (CYPs) play a crucial role in the metabolism and synthesis of various compound classes. While drug-metabolizing CYP enzymes are…”
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    Journal Article
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