Search Results - "Künzel, Steffen"

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation by Zarkada, Georgia, Howard, Joel P., Xiao, Xue, Park, Hyojin, Bizou, Mathilde, Leclerc, Severine, Künzel, Steffen E., Boisseau, Blanche, Li, Jinyu, Cagnone, Gael, Joyal, Jean Sebastien, Andelfinger, Gregor, Eichmann, Anne, Dubrac, Alexandre

“…Endothelial tip cells guiding tissue vascularization are primary targets for angiogenic therapies. Whether tip cells require differential signals to develop…”
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Lacteal junction zippering protects against diet-induced obesity by Zhang, Feng, Zarkada, Georgia, Han, Jinah, Li, Jinyu, Dubrac, Alexandre, Ola, Roxana, Genet, Gael, Boyé, Kevin, Michon, Pauline, Künzel, Steffen E, Camporez, Joao Paulo, Singh, Abhishek K, Fong, Guo-Hua, Simons, Michael, Tso, Patrick, Fernández-Hernando, Carlos, Shulman, Gerald I, Sessa, William C, Eichmann, Anne

“…Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the…”
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Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis by Genet, Gael, Boyé, Kevin, Mathivet, Thomas, Ola, Roxana, Zhang, Feng, Dubrac, Alexandre, Li, Jinyu, Genet, Nafiisha, Henrique Geraldo, Luiz, Benedetti, Lorena, Künzel, Steffen, Pibouin-Fragner, Laurence, Thomas, Jean-Leon, Eichmann, Anne

“…Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of VEGFR2. However, how these cell behaviors are regulated…”
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NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy by Dubrac, Alexandre, Künzel, Steffen E., Künzel, Sandrine H., Li, Jinyu, Chandran, Rachana Radhamani, Martin, Kathleen, Greif, Daniel M., Adams, Ralf H., Eichmann, Anne

“…Pericytes are mural cells that surround capillaries and control angiogenesis and capillary barrier function. During sprouting angiogenesis, endothelial…”
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Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice by Künzel, Steffen E, Pompös, Inga-Marie, Flesch, Leonie T M, Frentzel, Dominik P, Knecht, Vitus A, Winkler, Silvia, Skosyrski, Sergej, Rübsam, Anne, Dreher, Felix, Kociok, Norbert, Schütte, Moritz, Dubrac, Alexandre, Lange, Bodo, Yaspo, Marie-Laure, Lehrach, Hans, Strauß, Olaf, Joussen, Antonia M, Zeitz, Oliver

“…We aimed to determine the impact of artificial sweeteners (AS), especially saccharin, on the progression and treatment efficacy of patients with neovascular…”
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Systemic Blood Proteome Patterns Reflect Disease Phenotypes in Neovascular Age-Related Macular Degeneration by Künzel, Steffen E, Flesch, Leonie T M, Frentzel, Dominik P, Knecht, Vitus A, Rübsam, Anne, Dreher, Felix, Schütte, Moritz, Dubrac, Alexandre, Lange, Bodo, Yaspo, Marie-Laure, Lehrach, Hans, Joussen, Antonia M, Zeitz, Oliver

“…There is early evidence of extraocular systemic signals effecting function and morphology in neovascular age-related macular degeneration (nAMD). The…”
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Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy by Künzel, Sandrine H, Pohlmann, Dominika, Bonsen, Lynn zur, Krappitz, Matteus, Zeitz, Oliver, Joussen, Antonia M, Dubrac, Alexandre, Künzel, Steffen E

“…Background Central Serous Chorioretinopathy (CSCR) manifests as fluid accumulation between the neurosensory retina and the retinal pigment epithelium (RPE)…”
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Exploring Non-Modifiable and Modifiable Determinants of Vision-Related Quality of Life in Central Serous Chorioretinopathy by Künzel, Steffen E, Kabiri, Payam, Zur Bonsen, Lynn, Frentzel, Dominik P, Böker, Alexander, Joussen, Antonia M, Zeitz, Oliver

“…To longitudinally investigate the impact of best-corrected visual acuity (BCVA), non-modifiable risk factors, modifiable habits, and disease course on the…”
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Low vulnerability of the posterior eye segment to SARS-CoV-2 infection by Künzel, Steffen Emil, Bürgel, Thore, Künzel, Sandrine Helene, Pohlmann, Dominika, Zeitz, Oliver, Joussen, Antonia, Dubrac, Alexandre

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LOW VULNERABILITY OF THE POSTERIOR EYE SEGMENT TO SARS-COV-2 INFECTION: Chorioretinal SARS-CoV-2 Vulnerability by Künzel, Steffen Emil, Bürgel, Thore, Künzel, Sandrine Helene, Pohlmann, Dominika, Zeitz, Oliver, Joussen, Antonia, Dubrac, Alexandre

“…Retinal manifestations have been described in COVID-19 patients, but it is unknown whether SARS-CoV-2, the causal agent in COVID-19, can directly infect…”
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AI-driven discovery of blood xenobiotic biomarkers in neovascular age-related macular degeneration using iterative random forests by Künzel, Steffen E, Frentzel, Dominik P, Flesch, Leonie T M, Knecht, Vitus A, Rübsam, Anne, Dreher, Felix, Schütte, Moritz, Dubrac, Alexandre, Lange, Bodo, Yaspo, Marie-Laure, Lehrach, Hans, Joussen, Antonia M, Zeitz, Oliver

“…To investigate the xenobiotic profiles of patients with neovascular age-related macular degeneration (nAMD) undergoing anti-vascular endothelial growth factor…”
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Using Deep Learning to Distinguish Highly Malignant Uveal Melanoma from Benign Choroidal Nevi by Hoffmann, Laura, Runkel, Constance B, Künzel, Steffen, Kabiri, Payam, Rübsam, Anne, Bonaventura, Theresa, Marquardt, Philipp, Haas, Valentin, Biniaminov, Nathalie, Biniaminov, Sergey, Joussen, Antonia M, Zeitz, Oliver

“…This study aimed to evaluate the potential of human-machine interaction (HMI) in a deep learning software for discerning the malignancy of choroidal…”
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Longitudinal Comparison of Constant Artifacts in Optical Coherence Tomography Angiography in Patients with Posterior Uveitis Compared to Healthy Subjects by Pohlmann, Dominika, Berlin, Martin, Reidl, Felix, Künzel, Steffen Emil, Pleyer, Uwe, Joussen, Antonia M, Winterhalter, Sibylle

“…Background: Knowledge about artifacts in optical coherence tomography angiography (OCTA) is important to avoid misinterpretations. An overview of possible…”
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