Search Results - "Küng, Erich"

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment by Jaklin, Manuela, Zhang, Jitao David, Schäfer, Nicole, Clemann, Nicole, Barrow, Paul, Küng, Erich, Sach-Peltason, Lisa, McGinnis, Claudia, Leist, Marcel, Kustermann, Stefan

“…Abstract Current animal-free methods to assess teratogenicity of drugs under development still deliver high numbers of false negatives. To improve the…”
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Pathway reporter genes define molecular phenotypes of human cells by Zhang, Jitao David, Küng, Erich, Boess, Franziska, Certa, Ulrich, Ebeling, Martin

“…The phenotype of a living cell is determined by its pattern of active signaling networks, giving rise to a "molecular phenotype" associated with differential…”
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Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment by Ebeling, Martin, Küng, Erich, See, Angela, Broger, Clemens, Steiner, Guido, Berrera, Marco, Heckel, Tobias, Iniguez, Leonardo, Albert, Thomas, Schmucki, Roland, Biller, Hermann, Singer, Thomas, Certa, Ulrich

“…The long-tailed macaque, also referred to as cynomolgus monkey (Macaca fascicularis), is one of the most important nonhuman primate animal models in basic and…”
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Erratum to: Pathway reporter genes define molecular phenotypes of human cells by Zhang, Jitao David, Küng, Erich, Boess, Franziska, Certa, Ulrich, Ebeling, Martin

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High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing by Henson, Sonal, Bishop, Richard P, Morzaria, Subhash, Spooner, Paul R, Pelle, Roger, Poveda, Lucy, Ebeling, Martin, Küng, Erich, Certa, Ulrich, Daubenberger, Claudia A, Qi, Weihong

“…Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the…”
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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery by Drawnel, Faye Marie, Zhang, Jitao David, Küng, Erich, Aoyama, Natsuyo, Benmansour, Fethallah, Araujo Del Rosario, Andrea, Jensen Zoffmann, Sannah, Delobel, Frédéric, Prummer, Michael, Weibel, Franziska, Carlson, Coby, Anson, Blake, Iacone, Roberto, Certa, Ulrich, Singer, Thomas, Ebeling, Martin, Prunotto, Marco

“…Today, novel therapeutics are identified in an environment which is intrinsically different from the clinical context in which they are ultimately evaluated…”
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Functional analysis and transcriptional output of the Göttingen minipig genome by Heckel, Tobias, Schmucki, Roland, Berrera, Marco, Ringshandl, Stephan, Badi, Laura, Steiner, Guido, Ravon, Morgane, Küng, Erich, Kuhn, Bernd, Kratochwil, Nicole A, Schmitt, Georg, Kiialainen, Anna, Nowaczyk, Corinne, Daff, Hamina, Khan, Azinwi Phina, Lekolool, Isaac, Pelle, Roger, Okoth, Edward, Bishop, Richard, Daubenberger, Claudia, Ebeling, Martin, Certa, Ulrich

“…In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many…”
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Highly sensitive amplicon-based transcript quantification by semiconductor sequencing by Zhang, Jitao David, Schindler, Tobias, Küng, Erich, Ebeling, Martin, Certa, Ulrich

“…In clinical and basic research custom panels for transcript profiling are gaining importance because only project specific informative genes are interrogated…”
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A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies by Flisikowska, Tatiana, Egli, Jerome, Flisikowski, Krzysztof, Stumbaum, Marlene, Küng, Erich, Ebeling, Martin, Schmucki, Roland, Georges, Guy, Singer, Thomas, Kurome, Mayuko, Kessler, Barbara, Zakhartchenko, Valeri, Wolf, Eckhard, Weber, Felix, Schnieke, Angelika, Iglesias, Antonio

“…The safety of most human recombinant proteins can be evaluated in transgenic mice tolerant to specific human proteins. However, owing to insufficient genetic…”
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Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases by Grueninger-Leitch, F, Schlatter, D, Kueng, E, Nelboeck, P, Doebeli, H

“…The full-length and ectodomain forms of β-site APP cleavage enzyme (BACE) have been cloned, expressed in Sf9 cells, and purified to homogeneity. This aspartic…”
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High throughput transcriptome analysis of lipid metabolism in Syrian hamster liver in absence of an annotated genome by Schmucki, Roland, Berrera, Marco, Küng, Erich, Lee, Serene, Thasler, Wolfgang E, Grüner, Sabine, Ebeling, Martin, Certa, Ulrich

“…Whole transcriptome analyses are an essential tool for understanding disease mechanisms. Approaches based on next-generation sequencing provide fast and…”
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Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 Å resolution by Thoma, Ralf, Küng, Erich, Stihle, Martine, Borroni, Edilio, Cesura, Andrea, Schlatter, Daniel, Müller, Francis, Hennig, Michael

“…In the pharmaceutical industry, knowledge of the three‐dimensional structure of a specific target facilitates the drug‐discovery process. Despite possessing…”
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Semimalignant ("pseudolymphomatous") cutaneous B-cell lymphomas by Burg, G, Schmid, M H, Küng, E, Dommann, S, Dummer, R

“…Almost 50% of cutaneous B-cell lymphoproliferative infiltrates are derived from follicular center cells. Among these, about 25% show a rapidly progressive…”
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Chemical synthesis of O-thiophosphotyrosyl peptides by Kitas, E, Küng, E, Bannwarth, W

“…The synthon for O-thiophosphotyrosine, Fmoc-Tyr[PS(OBzl)2]-OH (1c), was prepared in 63% yield from Fmoc-Tyr-OH by first transient protection as the…”
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