Search Results - "Küllmer, Florian"

Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM by Merino, Felipe, Pospich, Sabrina, Funk, Johanna, Wagner, Thorsten, Küllmer, Florian, Arndt, Hans-Dieter, Bieling, Peter, Raunser, Stefan

“…The function of actin is coupled to the nucleotide bound to its active site. ATP hydrolysis is activated during polymerization; a delay between hydrolysis and…”
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Optical Manipulation of F‑Actin with Photoswitchable Small Molecules by Borowiak, Malgorzata, Küllmer, Florian, Gegenfurtner, Florian, Peil, Sebastian, Nasufovic, Veselin, Zahler, Stefan, Thorn-Seshold, Oliver, Trauner, Dirk, Arndt, Hans-Dieter

“…Cell-permeable photoswitchable small molecules, termed optojasps, are introduced to optically control the dynamics of the actin cytoskeleton and cellular…”
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An Orthogonally Protected Cyclitol for the Construction of Nigerose- and Dextran-Mimetic Cyclophellitols by Ofman, Tim P, Küllmer, Florian, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S

“…Cyclophellitols are potent inhibitors of exo- and endoglycosidases. Efficient synthetic methodologies are needed to fully capitalize on this intriguing class…”
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Cryo‐EM Resolves Molecular Recognition Of An Optojasp Photoswitch Bound To Actin Filaments In Both Switch States by Pospich, Sabrina, Küllmer, Florian, Nasufović, Veselin, Funk, Johanna, Belyy, Alexander, Bieling, Peter, Arndt, Hans‐Dieter, Raunser, Stefan

“…Actin is essential for key processes in all eukaryotic cells. Cellpermeable optojasps provide spatiotemporal control of the actin cytoskeleton, confining…”
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Identification of the growth cone as a probe and driver of neuronal migration in the injured brain by Nakajima, Chikako, Sawada, Masato, Umeda, Erika, Takagi, Yuma, Nakashima, Norihiko, Kuboyama, Kazuya, Kaneko, Naoko, Yamamoto, Satoaki, Nakamura, Haruno, Shimada, Naoki, Nakamura, Koichiro, Matsuno, Kumiko, Uesugi, Shoji, Vepřek, Nynke A., Küllmer, Florian, Nasufović, Veselin, Uchiyama, Hironobu, Nakada, Masaru, Otsuka, Yuji, Ito, Yasuyuki, Herranz-Pérez, Vicente, García-Verdugo, José Manuel, Ohno, Nobuhiko, Arndt, Hans-Dieter, Trauner, Dirk, Tabata, Yasuhiko, Igarashi, Michihiro, Sawamoto, Kazunobu

“…Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading…”
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Next Generation Opto‐Jasplakinolides Enable Local Remodeling of Actin Networks by Küllmer, Florian, Vepřek, Nynke A., Borowiak, Malgorzata, Nasufović, Veselin, Barutzki, Sebastian, Thorn‐Seshold, Oliver, Arndt, Hans‐Dieter, Trauner, Dirk

“…The natural product jasplakinolide is widely used to stabilize F‐actin. Based on extensive structure–activity relationship studies, we have developed a new…”
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Conformational and Electronic Variations in 1,2‐ and 1,5a‐Cyclophellitols and their Impact on Retaining α‐Glucosidase Inhibition by Ofman, Tim P., Heming, Jurriaan J. A., Nin‐Hill, Alba, Küllmer, Florian, Moran, Elisha, Bennett, Megan, Steneker, Roy, Klein, Anne‐Mei, Ruijgrok, Gijs, Kok, Ken, Armstrong, Zach W. B., Aerts, Johannes M. F. G., Marel, Gijsbert A., Rovira, Carme, Davies, Gideon J., Artola, Marta, Codée, Jeroen D. C., Overkleeft, Herman S.

“…Glycoside hydrolases (glycosidases) take part in myriad biological processes and are important therapeutic targets. Competitive and mechanism‐based inhibitors…”
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Total Synthesis and Bioactivity Mapping of Geodiamolide H by Nasufović, Veselin, Küllmer, Florian, Bößneck, Johanna, Dahse, Hans‐Martin, Görls, Helmar, Bellstedt, Peter, Stallforth, Pierre, Arndt, Hans‐Dieter

“…The first total synthesis of the actin‐stabilizing marine natural product geodiamolide H was achieved. Solid‐phase based peptide assembly paired with scalable…”
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Next Generation Opto‐Jasplakinolides Enable Local Remodeling of Actin Networks by Küllmer, Florian, Vepřek, Nynke A., Borowiak, Malgorzata, Nasufović, Veselin, Barutzki, Sebastian, Thorn‐Seshold, Oliver, Arndt, Hans‐Dieter, Trauner, Dirk

“…The natural product jasplakinolide is widely used to stabilize F‐actin. Based on extensive structure–activity relationship studies, we have developed a new…”
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Cryo‐EM Resolves Molecular Recognition Of An Optojasp Photoswitch Bound To Actin Filaments In Both Switch States by Pospich, Sabrina, Küllmer, Florian, Nasufović, Veselin, Funk, Johanna, Belyy, Alexander, Bieling, Peter, Arndt, Hans‐Dieter, Raunser, Stefan

“…Actin is essential for key processes in all eukaryotic cells. Cellpermeable optojasps provide spatiotemporal control of the actin cytoskeleton, confining…”
Get full text