Search Results - "Kühnlein, P"

Triacylglycerol Metabolism in Drosophila melanogaster by Heier, Christoph, Kühnlein, Ronald P

“…Triacylglycerol (TAG) is the most important caloric source with respect to energy homeostasis in animals. In addition to its evolutionarily conserved…”
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Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos by Li, Zhihuan, Thiel, Katharina, Thul, Peter J., Beller, Mathias, Kühnlein, Ronald P., Welte, Michael A.

“…Histones are essential for chromatin packing, yet free histones not incorporated into chromatin are toxic. While in most cells multiple regulatory mechanisms…”
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Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants by Gáliková, Martina, Diesner, Max, Klepsatel, Peter, Hehlert, Philip, Xu, Yanjun, Bickmeyer, Iris, Predel, Reinhard, Kühnlein, Ronald P

“…Maintenance of biological functions under negative energy balance depends on mobilization of storage lipids and carbohydrates in animals. In mammals, glucagon…”
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Reliable Drosophila body fat quantification by a coupled colorimetric assay by Hildebrandt, Anja, Bickmeyer, Iris, Kühnlein, Ronald P

“…Factors and mechanisms controlling lipometabolism homeostasis share a remarkable evolutionary conservation between humans and Drosophila flies. Accordingly,…”
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Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis by Dorst, J., Kühnlein, P., Hendrich, C., Kassubek, J., Sperfeld, A. D., Ludolph, A. C.

“…Weight loss is a common phenomenon and an independent prognostic factor in amyotrophic lateral sclerosis (ALS). Several potential causal mechanisms, including…”
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Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization by Bi, Junfeng, Xiang, Yanhui, Chen, Haiyang, Liu, Zhonghua, Grönke, Sebastian, Kühnlein, Ronald P, Huang, Xun

“…Lipid droplets are the main lipid storage sites in cells. Lipid droplet homeostasis is regulated by the surface accessibility of lipases. Mammalian adipose…”
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The contribution of the Drosophila model to lipid droplet research by Kühnlein, Ronald P.

“…Intracellular lipid droplets have long been misconceived as evolutionarily conserved but functionally frugal components of cellular metabolism. An ever-growing…”
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The obesity‐related Adipokinetic hormone controls feeding and expression of neuropeptide regulators of Drosophila metabolism by Gáliková, Martina, Klepsatel, Peter, Xu, Yanjun, Kühnlein, Ronald P.

“…Homeostasis of circulating and storage energy reserves in mammals is dependent on the antagonistically acting insulin and glucagon signaling. In the model…”
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Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease by Girard, Victor, Jollivet, Florence, Knittelfelder, Oskar, Celle, Marion, Arsac, Jean-Noel, Chatelain, Gilles, Van den Brink, Daan M, Baron, Thierry, Shevchenko, Andrej, Kühnlein, Ronald P, Davoust, Nathalie, Mollereau, Bertrand

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid…”
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Dual lipolytic control of body fat storage and mobilization in Drosophila by Grönke, Sebastian, Müller, Günter, Hirsch, Jochen, Fellert, Sonja, Andreou, Alexandra, Haase, Tobias, Jäckle, Herbert, Kühnlein, Ronald P

“…Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body…”
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PERILIPIN-Dependent Control of Lipid Droplet Structure and Fat Storage in Drosophila by Beller, Mathias, Bulankina, Anna V., Hsiao, He-Hsuan, Urlaub, Henning, Jäckle, Herbert, Kühnlein, Ronald P.

“…Lipid droplets are intracellular organelles enriched in adipose tissue that govern the body fat stores of animals. In mammals, members of the evolutionarily…”
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A Drosophila In Vivo Screen Identifies Store-Operated Calcium Entry as a Key Regulator of Adiposity by Baumbach, Jens, Hummel, Petra, Bickmeyer, Iris, Kowalczyk, Katarzyna M., Frank, Martina, Knorr, Konstantin, Hildebrandt, Anja, Riedel, Dietmar, Jäckle, Herbert, Kühnlein, Ronald P.

“…To unravel the evolutionarily conserved genetic network underlying energy homeostasis, we performed a systematic in vivo gene knockdown screen in Drosophila…”
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The α/β-hydrolase domain-containing 4- and 5-related phospholipase Pummelig controls energy storage in Drosophila by Hehlert, Philip, Hofferek, Vinzenz, Heier, Christoph, Eichmann, Thomas O., Riedel, Dietmar, Rosenberg, Jonathan, Takaćs, Anna, Nagy, Harald M., Oberer, Monika, Zimmermann, Robert, Kühnlein, Ronald P.

“…Triglycerides (TGs) are the main energy storage form that accommodates changing organismal energy demands. In Drosophila melanogaster, the TG lipase Brummer is…”
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Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success by Heier, Christoph, Knittelfelder, Oskar, Hofbauer, Harald F, Mende, Wolfgang, Pörnbacher, Ingrid, Schiller, Laura, Schoiswohl, Gabriele, Xie, Hao, Grönke, Sebastian, Shevchenko, Andrej, Kühnlein, Ronald P

“…Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and…”
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Characterization of the Drosophila Lipid Droplet Subproteome by Beller, Mathias, Riedel, Dietmar, Jaensch, Lothar, Dieterich, Guido, Wehland, Juergen, Jaeckle, Herbert, Kuehnlein, Ronald P

“…Lipid storage droplets are universal organelles essential for the cellular and organismal lipometabolism including energy homeostasis. Despite their apparently…”
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orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control by Fernandez-Acosta, Magdalena, Romero, Juan I, Bernabó, Guillermo, Velázquez-Campos, Giovanna M, Gonzalez, Nerina, Mares, M. Lucía, Werbajh, Santiago, Avendaéo-Vázquez, L. Amaranta, Rechberger, Gerald N, Kühnlein, Ronald P, Marino-Buslje, Cristina, Cantera, Rafael, Rezaval, Carolina, Ceriani, M. Fernanda

“…Lipid homeostasis is an evolutionarily conserved process that is crucial for energy production, storage and consumption. Drosophila larvae feed continuously to…”
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Diacylglycerol triggers Rim101 pathway–dependent necrosis in yeast: a model for lipotoxicity by Rockenfeller, Patrick, Smolnig, Martin, Diessl, Jutta, Bashir, Mina, Schmiedhofer, Vera, Knittelfelder, Oskar, Ring, Julia, Franz, Joakim, Foessl, Ines, Khan, Muhammad J., Rost, René, Graier, Wolfgang F., Kroemer, Guido, Zimmermann, Andreas, Carmona-Gutierrez, Didac, Eisenberg, Tobias, Büttner, Sabrina, Sigrist, Stephan J., Kühnlein, Ronald P., Kohlwein, Sepp D., Gourlay, Campbell W., Madeo, Frank

“…The loss of lipid homeostasis can lead to lipid overload and is associated with a variety of disease states. However, little is known as to how the disruption…”
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Control of fat storage by a Drosophila PAT domain protein by Grönke, Sebastian, Beller, Mathias, Fellert, Sonja, Ramakrishnan, Hariharasubramanian, Jäckle, Herbert, Kühnlein, Ronald P

“…In Drosophila, the masses and sheets of adipose tissue that are distributed throughout the fly are collectively called the fat body. Like mammalian adipocytes,…”
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Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging by Hänschke, Lea, Heier, Christoph, Maya Palacios, Santiago José, Özek, Huseyin Erdem, Thiele, Christoph, Bauer, Reinhard, Kühnlein, Ronald P., Bülow, Margret H.

“…The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency…”
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Drosophila as a model to study obesity and metabolic disease by Musselman, Laura Palanker, Kühnlein, Ronald P

“…Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of both the rate of incidence and the severity of obesity-associated…”
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