Search Results - "Kühn, Michael W M"

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations by Edelmann, Jennifer, Holzmann, Karlheinz, Miller, Florian, Winkler, Dirk, Bühler, Andreas, Zenz, Thorsten, Bullinger, Lars, Kühn, Michael W.M., Gerhardinger, Andreas, Bloehdorn, Johannes, Radtke, Ina, Su, Xiaoping, Ma, Jing, Pounds, Stanley, Hallek, Michael, Lichter, Peter, Korbel, Jan, Busch, Raymonde, Mertens, Daniel, Downing, James R., Stilgenbauer, Stephan, Döhner, Hartmut

“…To identify genomic alterations in chronic lymphocytic leukemia (CLL), we performed single-nucleotide polymorphism–array analysis using Affymetrix Version 6.0…”
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Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia by Albinger, Nawid, Pfeifer, Rita, Nitsche, Marcus, Mertlitz, Sarah, Campe, Julia, Stein, Katja, Kreyenberg, Hermann, Schubert, Ralf, Quadflieg, Melissa, Schneider, Dina, Kühn, Michael W. M., Penack, Olaf, Zhang, Congcong, Möker, Nina, Ullrich, Evelyn

“…Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic myeloid progenitor cells characterized by abnormal proliferation and…”
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Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia by Tubío-Santamaría, Nuria, Jayavelu, Ashok Kumar, Schnoeder, Tina M, Eifert, Theresa, Hsu, Chen-Jen, Perner, Florian, Zhang, Qirui, Wenge, Daniela V, Hansen, Fynn M, Kirkpatrick, Joanna M, Jyotsana, Nidhi, Lane, Steven W, von Eyss, Björn, Deshpande, Aniruddha J, Kühn, Michael W M, Schwaller, Juerg, Cammann, Clemens, Seifert, Ulrike, Ebstein, Frédéric, Krüger, Elke, Hochhaus, Andreas, Heuser, Michael, Ori, Alessandro, Mann, Matthias, Armstrong, Scott A, Heidel, Florian H

“…Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML)…”
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Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia by Krönke, Jan, Bullinger, Lars, Teleanu, Veronica, Tschürtz, Florian, Gaidzik, Verena I., Kühn, Michael W.M., Rücker, Frank G., Holzmann, Karlheinz, Paschka, Peter, Kapp-Schwörer, Silke, Späth, Daniela, Kindler, Thomas, Schittenhelm, Marcus, Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

“…Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal…”
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Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing by Dolnik, Anna, Engelmann, Julia C., Scharfenberger-Schmeer, Maren, Mauch, Julian, Kelkenberg-Schade, Sabine, Haldemann, Berit, Fries, Tamara, Krönke, Jan, Kühn, Michael W.M., Paschka, Peter, Kayser, Sabine, Wolf, Stephan, Gaidzik, Verena I., Schlenk, Richard F., Rücker, Frank G., Döhner, Hartmut, Lottaz, Claudio, Döhner, Konstanze, Bullinger, Lars

“…Acute myeloid leukemia (AML) is characterized by molecular heterogeneity. As commonly altered genomic regions point to candidate genes involved in…”
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High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations by Kühn, Michael W.M., Radtke, Ina, Bullinger, Lars, Goorha, Salil, Cheng, Jinjun, Edelmann, Jennifer, Gohlke, Juliane, Su, Xiaoping, Paschka, Peter, Pounds, Stanley, Krauter, Jürgen, Ganser, Arnold, Quessar, Asmaa, Ribeiro, Raul, Gaidzik, Verena I., Shurtleff, Sheila, Krönke, Jan, Holzmann, Karlheinz, Ma, Jing, Schlenk, Richard F., Rubnitz, Jeffrey E., Döhner, Konstanze, Döhner, Hartmut, Downing, James R.

“…To identify cooperating lesions in core-binding factor acute myeloid leukemia, we performed single-nucleotide polymorphism-array analysis on 300 diagnostic and…”
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Refinement of the prognostic impact of somatic CEBPA bZIP domain mutations in acute myeloid leukemia: Results of the AML Study Group (AMLSG) by Rücker, Frank G., Corbacioglu, Andrea, Krzykalla, Julia, Cocciardi, Sibylle, Lengerke, Claudia, Germing, Ulrich, Wulf, Gerald, Samra, Maisun A., Teichmann, Lino L., Lübbert, Michael, Kühn, Michael W. M., Bentz, Martin, Westermann, Jörg, Bullinger, Lars, Gaidzik, Verena I., Meid, Annika, Aicher, Sophia, Stegelmann, Frank, Weber, Daniela, Schrade, Anika, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Benner, Axel, Döhner, Hartmut, Döhner, Konstanze

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The Menin story in acute myeloid leukaemia—The road to success by Kühn, Michael W. M., Ganser, Arnold

“…The treatment of acute myeloid leukaemia (AML) has changed fundamentally in the last decade with many new targeted therapies entering clinics. Some of the most…”
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Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition by Dzama, Margarita M., Steiner, Marlene, Rausch, Johanna, Sasca, Daniel, Schönfeld, Jonas, Kunz, Kerstin, Taubert, Martha C., McGeehan, Gerard M., Chen, Chun-Wei, Mupo, Annalisa, Hähnel, Patricia, Theobald, Matthias, Kindler, Thomas, Koche, Richard P., Vassiliou, George S., Armstrong, Scott A., Kühn, Michael W.M.

“…The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and…”
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Next generation epigenetic modulators to target myeloid neoplasms by Sasca, Daniel, Guezguez, Borhane, Kühn, Michael W.M.

“…Purpose of review Comprehensive sequencing studies aimed at determining the genetic landscape of myeloid neoplasms have identified epigenetic regulators to be…”
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Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax by Rausch, Johanna, Dzama, Margarita M, Dolgikh, Nadezda, Stiller, Hanna L, Bohl, Stephan R, Lahrmann, Catharina, Kunz, Kerstin, Kessler, Linda, Echchannaoui, Hakim, Chen, Chun-Wei, Kindler, Thomas, Döhner, Konstanze, Burrows, Francis, Theobald, Matthias, Sasca, Daniel, Kühn, Michael W M

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Midostaurin plus intensive chemotherapy for younger and older Patients with AML and FLT3 internal tandem duplications by Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Wulf, Gerald Georg, Salih, Helmut R, Lübbert, Michael, Kühn, Michael, Schroeder, Thomas, Salwender, Hans, Götze, Katharina S, Westermann, Jörg, Fransecky, Lars, Mayer, Karin, Hertenstein, Bernd, Ringhoffer, Mark, Tischler, Hans-Joachim, Machherndl-Spandl, Sigrid, Schrade, Anika, Paschka, Peter, Gaidzik, Verena I, Theis, Frauke, Thol, Felicitas R, Heuser, Michael, Schlenk, Richard F, Bullinger, Lars, Saadati, Maral, Benner, Axel, Larson, Richard A, Stone, Richard M, Döhner, Konstanze, Ganser, Arnold

“…We conducted a single-arm phase-II trial (AMLSG 16-10) to evaluate midostaurin with intensive chemotherapy followed by allogeneic hematopoietic-cell…”
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Cluster of differentiation 33 single nucleotide polymorphism rs12459419 is a predictive factor in patients with nucleophosmin1 -mutated acute myeloid leukemia receiving gemtuzumab ozogamicin by Teich, Katrin, Krzykalla, Julia, Kapp-Schwoerer, Silke, Gaidzik, Verena I, Schlenk, Richard F, Paschka, Peter, Weber, Daniela, Fiedler, Walter, Kühn, Michael W M, Schroeder, Thomas, Mayer, Karin, Lübbert, Michael, Ramachandran, Dhanya, Benner, Axel, Ganser, Arnold, Döhner, Hartmut, Heuser, Michael, Döhner, Konstanze, Thol, Felicitas

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Measurable Residual Disease Monitoring in AML With FLT3-ITD Treated With Intensive Chemotherapy Plus Midostaurin by Rücker, Frank G, Bullinger, Lars, Cocciardi, Sibylle, Skambraks, Sabrina, Luck, Tamara J, Weber, Daniela, Krzykalla, Julia, Pozek, Ema, Schneider, Isabelle Janina, Corbacioglu, Andrea, Gaidzik, Verena I, Meid, Dr, Annika, Aicher, Sophia, Stegelmann, Frank, Schrade, Anika, Theis, Frauke, Fiedler, Walter, Salih, Helmut R, Wulf, Gerald G, Salwender, Hans J, Schroeder, Thomas, Götze, Katharina S, Kühn, Michael W M, Lübbert, Michael, Schlenk, Richard F, Benner, Axel, Thol, Felicitas R, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze

“…Measurable residual disease (MRD) monitoring in acute myeloid leukemia (AML) with FLT3 internal tandem duplication (FLT3-ITDpos) was hampered by the broad…”
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Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia by Kühn, Michael W M, Song, Evelyn, Feng, Zhaohui, Sinha, Amit, Chen, Chun-Wei, Deshpande, Aniruddha J, Cusan, Monica, Farnoud, Noushin, Mupo, Annalisa, Grove, Carolyn, Koche, Richard, Bradner, James E, de Stanchina, Elisa, Vassiliou, George S, Hoshii, Takayuki, Armstrong, Scott A

“…Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX…”
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Assessment of Clonal Evolution in 42 AML with NPM1 Mutations by Molecular Characterization of Paired Diagnosis and Relapse Samples by Krönke, Jan, Bullinger, Lars, Rücker, Frank G., Gaidzik, Verena I., Kühn, Michael WM, Bezet, Karin, Teleanu, Veronica, Paschka, Peter, Späth, Daniela, Kindler, Thomas, Salih, Helmut R., Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

“…Abstract 237▪▪This icon denotes a clinically relevant abstract Mutations in the nucleophosmin 1 (NPM1) gene represent one of the most frequent gene mutations…”
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Integrative Genomics Approaches Identify Novel Disease-Related Genetic Aberrations in Acute Myeloid Leukemia by Dolnik, Anna, Engelmann, Julia C, Scharfenberger-Schmeer, Maren, Rücker, Frank G, Krönke, Jan, Kühn, Michael WM, Paschka, Peter, Gaidzik, Verena I., Kayser, Sabine, Schlenk, Richard F., Haldemann, Berit, Wolf, Stephan, Döhner, Hartmut, Lottaz, Claudio, Döhner, Konstanze, Bullinger, Lars

“…Abstract 402 Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic…”
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Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy by Rausch, Johanna, Ullrich, Evelyn, Kühn, Michael W.M.

“…AML is a malignant disease of hematopoietic progenitor cells with unsatisfactory treatment outcome, especially in patients that are ineligible for intensive…”
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Designed to Kill: Novel Menin-MLL Inhibitors Target MLL-Rearranged Leukemia by Kühn, Michael W.M., Armstrong, Scott A.

“…The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a…”
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Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09–09): a randomised, open-label, multicentre, phase 3 trial by Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Kühn, Michael W M, Schroeder, Thomas, Mayer, Karin, Lübbert, Michael, Wattad, Mohammed, Götze, Katharina, Fransecky, Lars, Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Ringhoffer, Mark, Greil, Richard, Hertenstein, Bernd, Krauter, Jürgen, Martens, Uwe M, Nachbaur, David, Samra, Maisun Abu, Machherndl-Spandl, Sigrid, Basara, Nadezda, Leis, Claudia, Schrade, Anika, Kapp-Schwoerer, Silke, Cocciardi, Sibylle, Bullinger, Lars, Thol, Felicitas, Heuser, Michael, Paschka, Peter, Gaidzik, Verena I, Saadati, Maral, Benner, Axel, Schlenk, Richard F, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Kühn, Michael W.M., Schroeder, Thomas, Mayer, Karin, Lübbert, Michael, Wattad, Mohammad, Götze, Katharina, Fransecky, Lars, Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Ringhoffer, Mark, Greil, Richard, Hertenstein, Bernd, Krauter, Jürgen, Martens, Uwe M., Nachbaur, David, Samra, Maisun Abu, Machherndl-Spandl, Sigrid, Basara, Nadezda, Leis, Claudia, Schrade, Anika, Kapp-Schwoerer, Silke, Cocciardi, Sibylle, Bullinger, Lars, Thol, Felicitas, Heuser, Michael, Paschka, Peter, Gaidzik, Verena I., Saadati, Maral, Benner, Axel, Schlenk, Richard F., Döhner, Konstanze, Ganser, Arnold

“…Acute myeloid leukaemia with mutated NPM1 is associated with high CD33 expression and intermediate-risk cytogenetics. The aim of this study was to evaluate…”
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