TB-related deaths among adults in Guinea-Bissau

SETTING: In an urban demographic, high TB burden surveillance site in Guinea-Bissau, most deaths occur at home, and information on cause of death (CoD) is lacking.OBJECTIVE: To examine CoD and the proportion of TB deaths in three groups: among patients examined for TB without a verified diagnosis af...

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Bibliographic Details
Published in:	The international journal of tuberculosis and lung disease Vol. 26; no. 7; pp. 664 - 670
Main Authors:	Kühle, A. J., Patsche, C. B., Fløe, A., Sifna, A., Gomes, V., Wejse, C., Rudolf, F.
Format:	Journal Article
Language:	English
Published:	France International Union Against Tuberculosis and Lung Disease 01-07-2022 International Union against Tuberculosis and Lung Disease (IUATLD)
Subjects:	Acquired Immunodeficiency Syndrome - mortality Adult Autopsies Autopsy Cause of Death Cause-Specific Mortality Diagnosis Fatalities Guinea-Bissau - epidemiology HIV Human immunodeficiency virus Humans Interva Population Tuberculosis - mortality Verbal Autopsy West Africa Guinea-Bissau Guinea Bissau
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Summary:	SETTING: In an urban demographic, high TB burden surveillance site in Guinea-Bissau, most deaths occur at home, and information on cause of death (CoD) is lacking.OBJECTIVE: To examine CoD and the proportion of TB deaths in three groups: among patients examined for TB without a verified diagnosis after diagnostic workup, described as "assumed TB-negative" (aTBneg), among patients with a confirmed diagnosis of TB and in a sample of the background population.DESIGN: Verbal autopsies (VAs) were obtained for registered deaths occurring between 1 January 2010 and 15 June 2016. All deaths among aTBneg and patients with TB, and a sample of deaths in the background population were included.RESULTS: VAs were obtained from 104/112 aTBneg patients, 140/155 patients with TB, and 172/219 from the general population. The leading CoD was TB in respectively 20%, 69% and 9% of the cohorts. HIV/AIDS-related deaths were the most frequent CoD among aTBneg patients (45%) and in the background population (27%), and accounted for 9% of patients with TB.CONCLUSION: TB was shown to be a frequent CoD, not only among patients diagnosed with TB, but also among aTBneg patients and the background population. This indicates a low TB case detection rate.
Bibliography:	1027-3719(20220701)26:7L.664;1- (R) Medicine - General ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1027-3719 1815-7920
DOI:	10.5588/ijtld.21.0483