Search Results - "Kühl, A. A."

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas by Staudacher, J. J, Arnold, Alexander, Kühl, A. A, Pötzsch, M, Daum, S, Winterfeld, M, Berg, E, Hummel, M, Rau, B, Stein, U, Treese, C

“…Abstract Purpose Adenocarcinomas of the esophagus (AEG) and stomach (AS) are among the most common cancers worldwide. Novel markers for risk stratification and…”
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Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages by Wu, Hao, Han, Yijie, Rodriguez Sillke, Yasmina, Deng, Hongzhang, Siddiqui, Sophiya, Treese, Christoph, Schmidt, Franziska, Friedrich, Marie, Keye, Jacqueline, Wan, Jiajia, Qin, Yue, Kühl, Anja A, Qin, Zhihai, Siegmund, Britta, Glauben, Rainer

“…Tumor‐associated macrophages (TAMs) promote tumor growth and metastasis by suppressing tumor immune surveillance. Herein, we provide evidence that the…”
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Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis by Perdomo, Carolina, Zedler, Ulrike, Kühl, Anja A, Lozza, Laura, Saikali, Philippe, Sander, Leif E, Vogelzang, Alexis, Kaufmann, Stefan H E, Kupz, Andreas

“…Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), yet its moderate efficacy against pulmonary TB calls…”
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Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models by Zwicker, Paula, Schleusener, Johannes, Lohan, Silke B., Busch, Loris, Sicher, Claudia, Einfeldt, Sven, Kneissl, Michael, Kühl, Anja A., Keck, Cornelia M., Witzel, Christian, Kramer, Axel, Meinke, Martina C.

“…A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was…”
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Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients by Gast, Martina, Rauch, Bernhard H, Haghikia, Arash, Nakagawa, Shinichi, Haas, Jan, Stroux, Andrea, Schmidt, David, Schumann, Paul, Weiss, Stefan, Jensen, Lars, Kratzer, Adelheid, Kraenkel, Nicolle, Müller, Christian, Börnigen, Daniela, Hirose, Tetsuro, Blankenberg, Stefan, Escher, Felicitas, Kühl, Anja A, Kuss, Andreas W, Meder, Benjamin, Landmesser, Ulf, Zeller, Tanja, Poller, Wolfgang

“…Abstract Aims Inflammation is a key driver of atherosclerosis and myocardial infarction (MI), and beyond proteins and microRNAs (miRs), long noncoding RNAs…”
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Diversity of Intestinal Macrophages in Inflammatory Bowel Diseases by Kühl, Anja A, Erben, Ulrike, Kredel, Lea I, Siegmund, Britta

“…Macrophages as innate immune cells and fast responders to antigens play a central role in protecting the body from the luminal content at a huge interface…”
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Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation by Bereswill, Stefan, Muñoz, Melba, Fischer, André, Plickert, Rita, Haag, Lea-Maxie, Otto, Bettina, Kühl, Anja A, Loddenkemper, Christoph, Göbel, Ulf B, Heimesaat, Markus M

“…The health beneficial effects of Resveratrol, Curcumin and Simvastatin have been demonstrated in various experimental models of inflammation. We investigated…”
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Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection by Muñoz, Melba, Eidenschenk, Celine, Ota, Naruhisa, Wong, Kit, Lohmann, Uwe, Kühl, Anja A, Wang, Xiaoting, Manzanillo, Paolo, Li, Yun, Rutz, Sascha, Zheng, Yan, Diehl, Lauri, Kayagaki, Nobuhiko, van Lookeren-Campagne, Menno, Liesenfeld, Oliver, Heimesaat, Markus, Ouyang, Wenjun

“…T helper 1 (Th1) cell-associated immunity exacerbates ileitis induced by oral Toxoplasma gondii infection. We show here that attenuated ileitis observed in…”
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A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow by Mei, Henrik E., Wirries, Ina, Frölich, Daniela, Brisslert, Mikael, Giesecke, Claudia, Grün, Joachim R., Alexander, Tobias, Schmidt, Stefanie, Luda, Katarzyna, Kühl, Anja A., Engelmann, Robby, Dürr, Michael, Scheel, Tobias, Bokarewa, Maria, Perka, Carsten, Radbruch, Andreas, Dörner, Thomas

“…Specific serum antibodies mediating humoral immunity and autoimmunity are provided by mature plasma cells (PC) residing in the bone marrow (BM), yet their…”
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Role of Blimp-1 in programing Th effector cells into IL-10 producers by Neumann, Christian, Heinrich, Frederik, Neumann, Katrin, Junghans, Victoria, Mashreghi, Mir-Farzin, Ahlers, Jonas, Janke, Marko, Rudolph, Christine, Mockel-Tenbrinck, Nadine, Kühl, Anja A, Heimesaat, Markus M, Esser, Charlotte, Im, Sin-Hyeog, Radbruch, Andreas, Rutz, Sascha, Scheffold, Alexander

“…Secretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism of self-limitation during infection. However, the…”
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Small intestinal nematode infection of mice is associated with increased enterobacterial loads alongside the intestinal tract by Rausch, Sebastian, Held, Josephin, Fischer, André, Heimesaat, Markus M, Kühl, Anja A, Bereswill, Stefan, Hartmann, Susanne

“…Parasitic nematodes are potent modulators of immune reactivity in mice and men. Intestinal nematodes live in close contact with commensal gut bacteria, provoke…”
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Intestinal helminth infection induces highly functional resident memory CD4+ T cells in mice by Steinfelder, Svenja, Rausch, Sebastian, Michael, Dörte, Kühl, Anja A., Hartmann, Susanne

“…Immunity to intestinal nematodes requires CD4⁺ Th2‐cell responses, including IL‐4 and IL‐13 production. Chronic infection with intestinal nematodes leads to…”
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Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory by Okhrimenko, Anna, Grün, Joachim R., Westendorf, Kerstin, Fang, Zhuo, Reinke, Simon, von Roth, Philipp, Wassilew, Georgi, Kühl, Anja A., Kudernatsch, Robert, Demski, Sonya, Scheibenbogen, Carmen, Tokoyoda, Koji, McGrath, Mairi A., Raftery, Martin J., Schönrich, Günther, Serra, Alessandro, Chang, Hyun-Dong, Radbruch, Andreas, Dong, Jun

“…In the bone marrow, a population of memory T cells has been described that promotes efficient secondary immune responses and has been considered to be…”
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Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity by Kieback, Elisa, Hilgenberg, Ellen, Stervbo, Ulrik, Lampropoulou, Vicky, Shen, Ping, Bunse, Mario, Jaimes, Yarua, Boudinot, Pierre, Radbruch, Andreas, Klemm, Uwe, Kühl, Anja A., Liblau, Roland, Hoevelmeyer, Nadine, Anderton, Stephen M., Uckert, Wolfgang, Fillatreau, Simon

“…Regulatory T (Treg) cells expressing Foxp3 transcripton factor are essential for immune homeostasis. They arise in the thymus as a separate lineage from…”
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Parasitic Nematodes Exert Antimicrobial Activity and Benefit From Microbiota-Driven Support for Host Immune Regulation by Rausch, Sebastian, Midha, Ankur, Kuhring, Matthias, Affinass, Nicole, Radonic, Aleksandar, Kühl, Anja A, Bleich, André, Renard, Bernhard Y, Hartmann, Susanne

“…Intestinal parasitic nematodes live in intimate contact with the host microbiota. Changes in the microbiome composition during nematode infection affect immune…”
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Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection by Elizalde-Velázquez, Luis E., Schlosser-Brandenburg, Josephine, Laubschat, Alexandra, Oser, Larissa, Kundik, Arkadi, Adjah, Joshua, Groenhagen, Saskia, Kühl, Anja A., Rausch, Sebastian, Hartmann, Susanne

“…Helminth infections lead to an overdispersion of the parasites in humans as well as in animals. We asked whether early immune responses against migrating…”
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Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice by Haag, Lea-Maxie, Fischer, André, Otto, Bettina, Plickert, Rita, Kühl, Anja A, Göbel, Ulf B, Bereswill, Stefan, Heimesaat, Markus M

“…The zoonotic pathogen Campylobacter jejuni is a leading cause of bacterial foodborne enterocolitis in humans worldwide. The understanding of immunopathology…”
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Novel murine infection models provide deep insights into the "ménage à trois" of Campylobacter jejuni, microbiota and host innate immunity by Bereswill, Stefan, Fischer, André, Plickert, Rita, Haag, Lea-Maxie, Otto, Bettina, Kühl, Anja A, Dasti, Javid I, Dashti, Javid I, Zautner, Andreas E, Muñoz, Melba, Loddenkemper, Christoph, Gross, Uwe, Göbel, Ulf B, Heimesaat, Markus M

“…Although Campylobacter jejuni-infections have a high prevalence worldwide and represent a significant socioeconomic burden, it is still not well understood how…”
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Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas by Duque-Correa, María A, Kühl, Anja A, Rodriguez, Paulo C, Zedler, Ulrike, Schommer-Leitner, Sandra, Rao, Martin, Weiner, 3rd, January, Hurwitz, Robert, Qualls, Joseph E, Kosmiadi, George A, Murray, Peter J, Kaufmann, Stefan H E, Reece, Stephen T

“…Significance Tuberculosis (TB) granulomas represent sites of both bacterial containment and tissue pathology. Macrophage killing of Mycobacterium tuberculosis…”
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Therapeutic potential of larval excretory/secretory proteins of the pig whipworm Trichuris suis in allergic disease by Ebner, F., Hepworth, M. R., Rausch, S., Janek, K., Niewienda, A., Kühl, A., Henklein, P., Lucius, R., Hamelmann, E., Hartmann, S.

“…Background Gastrointestinal nematodes are currently being evaluated as a novel therapeutic in the treatment of chronic human inflammatory disorders, due to…”
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