Search Results - "Küchler, Axel M"

Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation by Küchler, Axel M, Pollheimer, Jürgen, Balogh, Johanna, Sponheim, Jon, Manley, Linda, Sorensen, Dag R, De Angelis, Paula M, Scott, Helge, Haraldsen, Guttorm

“…Interleukin (IL)-33 is a novel member of the IL-1 family of cytokines that promotes Th2 responses in lymphocytes as well as the activation of both mast cells…”
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Inflammatory Bowel Disease-Associated Interleukin-33 Is Preferentially Expressed in Ulceration-Associated Myofibroblasts by Sponheim, Jon, Pollheimer, Jürgen, Olsen, Trine, Balogh, Johanna, Hammarström, Clara, Loos, Tamara, Kasprzycka, Monika, Sørensen, Dag Reidar, Nilsen, Hogne Røed, Küchler, Axel M, Vatn, Morten H, Haraldsen, Guttorm

“…Interleukin-33 (IL-33) is a novel member of the interleukin-1 family that induces mucosal pathology in vivo and may drive fibrosis development and…”
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Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage by Fernandes, Amilton M, Herlofsen, Sarah R, Karlsen, Tommy A, Küchler, Axel M, Fløisand, Yngvar, Brinchmann, Jan E

“…Lesions of hyaline cartilage do not heal spontaneously, and represent a therapeutic challenge. In vitro engineering of articular cartilage using cells and…”
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The Alarmin IL-33 Is a Notch Target in Quiescent Endothelial Cells by Sundlisæter, Eirik, Edelmann, Reidunn J, Hol, Johanna, Sponheim, Jon, Küchler, Axel M, Weiss, Miriam, Udalova, Irina A, Midwood, Kim S, Kasprzycka, Monika, Haraldsen, Guttorm

“…The molecular mechanisms that drive expression of the alarmin interleukin-33 (IL-33) in endothelial cells are unknown. Because nuclear IL-33 is a marker of…”
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Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells by Øynebråten, Inger, Barois, Nicolas, Bergeland, Trygve, Küchler, Axel M., Bakke, Oddmund, Haraldsen, Guttorm

“…Vascular endothelial cells present luminal chemokines that arrest rolling leukocytes by activating integrins. It appears that several chemokines must form…”
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Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in self-gelling alginate discs reveals novel chondrogenic signature gene clusters by Herlofsen, Sarah Roxana, Küchler, Axel M, Melvik, Jan Egil, Brinchmann, Jan E

“…We have used a disc-shaped self-gelling alginate hydrogel as a scaffold for in vitro chondrogenic differentiation of human bone marrow-derived mesenchymal stem…”
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Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery by Stav-Noraas, Tor Espen, Edelmann, Reidunn J, Poulsen, Lars La Cour, Sundnes, Olav, Phung, Danh, Küchler, Axel M, Müller, Fredrik, Kamen, Amine A, Haraldsen, Guttorm, Kaarbø, Mari, Hol, Johanna

“…IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells in healthy human tissues. We discovered that…”
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Family-with-sequence-similarity-46, member A (Fam46a) gene is expressed in developing tooth buds by Etokebe, Godfrey E, Küchler, Axel M, Haraldsen, Guttorm, Landin, Maria, Osmundsen, Harald, Dembic, Zlatko

“…Abstract Objective In search for possible novel genes that may be involved in tooth development, we analysed the genome-wide transcriptome of developing…”
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Interleukin-33 – cytokine of dual function or novel alarmin? by Haraldsen, Guttorm, Balogh, Johanna, Pollheimer, Jürgen, Sponheim, Jon, Küchler, Axel M

“…Cytokines are thought to exert biological effects through their specific cell surface membrane receptors but increasing evidence suggests that some also…”
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Development of the Zebrafish Lymphatic System Requires Vegfc Signaling by Küchler, Axel M., Gjini, Evisa, Peterson-Maduro, Josi, Cancilla, Belinda, Wolburg, Hartwig, Schulte-Merker, Stefan

“…Lymphangiogenesis results in the formation of a vascular network distinct from arteries and veins that serves to drain interstitial fluid from surrounding…”
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Interleukin-33 Drives a Proinflammatory Endothelial Activation That Selectively Targets Nonquiescent Cells by Pollheimer, Jürgen, Bodin, Johanna, Sundnes, Olav, Edelmann, Reidunn J, Skånland, Sigrid S, Sponheim, Jon, Brox, Mari Johanna, Sundlisæter, Eirik, Loos, Tamara, Vatn, Morten, Kasprzycka, Monika, Wang, Junbai, Küchler, Axel M, Taskén, Kjetil, Haraldsen, Guttorm, Hol, Johanna

“…OBJECTIVE—Interleukin (IL)-33 is a nuclear protein that is released from stressed or damaged cells to act as an alarmin. We investigated the effects of IL-33…”
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Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud by Grandel, Heiner, Lun, Klaus, Rauch, Gerd-Jörg, Rhinn, Muriel, Piotrowski, Tatjana, Houart, Corinne, Sordino, Paolo, Küchler, Axel M., Schulte-Merker, Stefan, Geisler, Robert, Holder, Nigel, Wilson, Stephen W., Brand, Michael

“…A number of studies have suggested that retinoic acid (RA) is an important signal for patterning the hindbrain, the branchial arches and the limb bud. Retinoic…”
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Molecular Requirements for Sorting of the Chemokine Interleukin-8/CXCL8 to Endothelial Weibel-Palade Bodies by Hol, Johanna, Küchler, Axel M., Johansen, Finn-Eirik, Dalhus, Bjørn, Haraldsen, Guttorm, Øynebråten, Inger

“…Sorting of proteins to Weibel-Palade bodies (WPB) of endothelial cells allows rapid regulated secretion of leukocyte-recruiting P-selectin and chemokines as…”
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The HUVEC/Matrigel assay: an in vivo assay of human angiogenesis suitable for drug validation by Skovseth, Dag K, Küchler, Axel M, Haraldsen, Guttorm

“…The future ability to manipulate the growth of new blood vessels (angiogenesis) holds great promise for treating ischemic disease and cancer. Several models of…”
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Large-scale mapping of mutations affecting zebrafish development by Geisler, Robert, Rauch, Gerd-Jörg, Geiger-Rudolph, Silke, Albrecht, Andrea, van Bebber, Frauke, Berger, Andrea, Busch-Nentwich, Elisabeth, Dahm, Ralf, Dekens, Marcus P S, Dooley, Christopher, Elli, Alexandra F, Gehring, Ines, Geiger, Horst, Geisler, Maria, Glaser, Stefanie, Holley, Scott, Huber, Matthias, Kerr, Andy, Kirn, Anette, Knirsch, Martina, Konantz, Martina, Küchler, Axel M, Maderspacher, Florian, Neuhauss, Stephan C, Nicolson, Teresa, Ober, Elke A, Praeg, Elke, Ray, Russell, Rentzsch, Brit, Rick, Jens M, Rief, Eva, Schauerte, Heike E, Schepp, Carsten P, Schönberger, Ulrike, Schonthaler, Helia B, Seiler, Christoph, Sidi, Samuel, Söllner, Christian, Wehner, Anja, Weiler, Christian, Nüsslein-Volhard, Christiane

“…Large-scale mutagenesis screens in the zebrafish employing the mutagen ENU have isolated several hundred mutant loci that represent putative developmental…”
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