Search Results - "Küçükköse, Emre"

KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer by Küçükköse, Emre, Peters, Niek A., Ubink, Inge, van Keulen, Veere A. M., Daghighian, Roxanna, Verheem, André, Laoukili, Jamila, Kranenburg, Onno

“…Expression profiling has identified four consensus molecular subtypes (CMS1-4) in colorectal cancer (CRC). The receptor tyrosine kinase KIT has been associated…”
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Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice by Küçükköse, Emre, Heesters, Balthasar A, Villaudy, Julien, Verheem, André, Cercel, Madalina, van Hal, Susan, Boj, Sylvia F, Borel Rinkes, Inne H M, Punt, Cornelis J A, Roodhart, Jeanine M L, Laoukili, Jamila, Koopman, Miriam, Spits, Hergen, Kranenburg, Onno

“…BackgroundThe immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune…”
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Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer by Küçükköse, Emre, Baars, Matthijs J. D., Amini, Mojtaba, Schraa, Suzanna J., Floor, Evelien, Bol, Guus M., Borel Rinkes, Inne H. M., Roodhart, Jeanine M. L., Koopman, Miriam, Laoukili, Jamila, Kranenburg, Onno, Vercoulen, Yvonne

“…Background The determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in colorectal cancer (CRC) are…”
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Mismatch Repair Status in Patient-Derived Colorectal Cancer Organoids Does Not Affect Intrinsic Tumor Cell Sensitivity to Systemic Therapy by Küçükköse, Emre, Wensink, G Emerens, Roelse, Celine M, van Schelven, Susanne J, Raats, Daniëlle A E, Boj, Sylvia F, Koopman, Miriam, Laoukili, Jamila, Roodhart, Jeanine M L, Kranenburg, Onno

“…DNA mismatch repair deficiency (dMMR) in metastatic colorectal cancer (mCRC) is associated with poor survival and a poor response to systemic treatment…”
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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids by Bolhaqueiro, Ana C. F., Ponsioen, Bas, Bakker, Bjorn, Klaasen, Sjoerd J., Kucukkose, Emre, van Jaarsveld, Richard H., Vivié, Judith, Verlaan-Klink, Ingrid, Hami, Nizar, Spierings, Diana C. J., Sasaki, Nobuo, Dutta, Devanjali, Boj, Sylvia F., Vries, Robert G. J., Lansdorp, Peter M., van de Wetering, Marc, van Oudenaarden, Alexander, Clevers, Hans, Kranenburg, Onno, Foijer, Floris, Snippert, Hugo J. G., Kops, Geert J. P. L.

“…Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are hallmarks of cancer in humans. A persistent high frequency of these errors…”
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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis by Laoukili, Jamila, van Schelven, Susanne, Küçükköse, Emre, Verheem, André, Goey, Kaitlyn, Koopman, Miriam, Borel Rinkes, Inne, Kranenburg, Onno

“…The presence of BRAFV600E in colorectal cancer (CRC) is associated with a higher chance of distant metastasis. Oxidative stress in disseminated tumor cells…”
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Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer by Küçükköse, Emre, Laoukili, Jamila, Gorelick, Alexander N., Degner, Sebastian, Laclé, Miangela M., van den Bent, Lotte, Peters, Niek A., Verheem, André, Hung, Wei-Ting, Frenkel, Nicola C., Wassenaar, Emma C.E., Lansu, Nico, Lenos, Kristiaan J., Vermeulen, Louis, Koopman, Miriam, Roodhart, Jeanine M.L., Kops, Geert J.P.L., Borel Rinkes, Inne H.M., Hagendoorn, Jeroen, Naxerova, Kamila, Kranenburg, Onno

“…Patients with colon cancer with liver metastases may be cured with surgery, but the presence of additional lung metastases often precludes curative treatment…”
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Abstract LB301: BRAFV600E drives WNT signalling in colorectal cancer via aberrant DNA methylation by Bouazzaoui, Layla El, Bugter, Jeroen M., Küçükköse, Emre, Verheem, André, Post, Jasmin B., Fenderico, Nicola, Rinkes, Inne H. Borel, Snippert, Hugo J., Maurice, Madelon M., Kranenburg, Onno

“…Abstract Objective: The BRAF V600E mutation drives the generation of an aggressive subtype of colorectal cancer (CRC). Although activation of WNT signalling is…”
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BRAF V600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis by Laoukili, Jamila, van Schelven, Susanne, Küçükköse, Emre, Verheem, André, Goey, Kaitlyn, Koopman, Miriam, Borel Rinkes, Inne, Kranenburg, Onno

“…The presence of BRAF in colorectal cancer (CRC) is associated with a higher chance of distant metastasis. Oxidative stress in disseminated tumor cells limits…”
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A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies, with recommendations for future research by Wensink, Emerens, Bond, Marinde, Kucukkose, Emre, May, Anne, Vink, Geraldine, Koopman, Miriam, Kranenburg, Onno, Roodhart, Jeanine

“…•dMMR mCRC patients have decreased chemosensitivity versus pMMR mCRC patients.•Different systemic non-immunotherapies show varying efficacy in dMMR mCRC…”
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Genomic Characterization of Colistin Heteroresistance in Klebsiella pneumoniae during a Nosocomial Outbreak by Halaby, Teysir, Kucukkose, Emre, Janssen, Axel B, Rogers, Malbert R C, Doorduijn, Dennis J, van der Zanden, Adri G M, Al Naiemi, Nashwan, Vandenbroucke-Grauls, Christina M J E, van Schaik, Willem

“…Klebsiella pneumoniae is emerging as an important nosocomial pathogen due to its rapidly increasing multidrug resistance, which has led to a renewed interest…”
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