Search Results - "Körner, Roman"

Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance by Gong, Jingyi, Körner, Roman, Gaitanos, Louise, Klein, Rüdiger

“…The cellular release of membranous vesicles known as extracellular vesicles (EVs) or exosomes represents a novel mode of intercellular communication. Eph…”
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Failure of RQC machinery causes protein aggregation and proteotoxic stress by Choe, Young-Jun, Park, Sae-Hun, Hassemer, Timm, Körner, Roman, Vincenz-Donnelly, Lisa, Hayer-Hartl, Manajit, Hartl, F. Ulrich

“…Translation of messenger RNAs lacking a stop codon results in the addition of a carboxy-terminal poly-lysine tract to the nascent polypeptide, causing ribosome…”
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proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together by Pathare, Ganesh Ramnath, Nagy, István, Bohn, Stefan, Unverdorben, Pia, Hubert, Agnes, Körner, Roman, Nickell, Stephan, Lasker, Keren, Sali, Andrej, Tamura, Tomohiro, Nishioka, Taiki, Förster, Friedrich, Baumeister, Wolfgang, Bracher, Andreas

“…Proteasomes execute the degradation of most cellular proteins. Although the 20S core particle (CP) has been studied in great detail, the structure of the 19S…”
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Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis by Honda, Reiko, Körner, Roman, Nigg, Erich A

“…The function of the Aurora B kinase at centromeres and the central spindle is crucial for chromosome segregation and cytokinesis, respectively. Herein, we have…”
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Human TPX2 Is Required for Targeting Aurora-A Kinase to the Spindle by Kufer, Thomas A., Herman H. W. Silljé, Körner, Roman, Gruss, Oliver J., Meraldi, Patrick, Nigg, Erich A.

“…Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a…”
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The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli by Zhao, Liang, Vecchi, Giulia, Vendruscolo, Michele, Körner, Roman, Hayer-Hartl, Manajit, Hartl, F. Ulrich

“…Stress-inducible molecular chaperones have essential roles in maintaining protein homeostasis, but the extent to which they affect overall proteome stability…”
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system by Saha, Itika, Yuste-Checa, Patricia, Da Silva Padilha, Miguel, Guo, Qiang, Körner, Roman, Holthusen, Hauke, Trinkaus, Victoria A., Dudanova, Irina, Fernández-Busnadiego, Rubén, Baumeister, Wolfgang, Sanders, David W., Gautam, Saurabh, Diamond, Marc I., Hartl, F. Ulrich, Hipp, Mark S.

“…Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The…”
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Quantitative Analysis of the Human Spindle Phosphoproteome at Distinct Mitotic Stages by Malik, Rainer, Lenobel, René, Santamaria, Anna, Ries, Albert, Nigg, Erich A, Körner, Roman

“…During mitosis, phosphorylation of spindle associated proteins is a key regulatory mechanism for spindle formation, mitotic progression, and cytokinesis. In…”
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High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins by Vincenz‐Donnelly, Lisa, Holthusen, Hauke, Körner, Roman, Hansen, Erik C, Presto, Jenny, Johansson, Jan, Sawarkar, Ritwick, Hartl, F Ulrich, Hipp, Mark S

“…Protein aggregation is associated with neurodegeneration and various other pathologies. How specific cellular environments modulate the aggregation of disease…”
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Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome by Ripaud, Leslie, Chumakova, Victoria, Antonin, Matthias, Hastie, Alex R., Pinkert, Stefan, Kömer, Roman, Ruff, Kiersten M., Pappu, Rohit V., Hornburg, Daniel, Mann, Matthias, Hartl, F. Ulrich, Hipp, Mark S.

“…Expansion of a poly-glutamine (polyQ) repeat in a group of functionally unrelated proteins is the cause of several inherited neurodegenerative disorders,…”
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PICH, a Centromere-Associated SNF2 Family ATPase, Is Regulated by Plk1 and Required for the Spindle Checkpoint by Baumann, Christoph, Körner, Roman, Hofmann, Kay, Nigg, Erich A.

“…We identify PICH (Plk1-interacting checkpoint “helicase”), a member of the SNF2 ATPase family, as an interaction partner and substrate of Plk1. Following…”
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Evaluation of the Low-Specificity Protease Elastase for Large-Scale Phosphoproteome Analysis by Wang, Bin, Malik, Rainer, Nigg, Erich A, Körner, Roman

“…Comprehensive phosphorylation site mapping is the central goal of phosphoproteome studies, but complete protein sequence coverage is rarely obtained using one…”
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Integrated Collinear Refractive Index Sensor with Ge PIN Photodiodes by Augel, Lion, Kawaguchi, Yuma, Bechler, Stefan, Körner, Roman, Schulze, Jörg, Uchida, Hironaga, Fischer, Inga A

“…Refractive index sensing is a highly sensitive and label-free detection method for molecular binding events. Commercial implementations of biosensing concepts…”
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An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space by Bie, Anne Sigaard, Cömert, Cagla, Körner, Roman, Corydon, Thomas J., Palmfeldt, Johan, Hipp, Mark S., Hartl, F. Ulrich, Bross, Peter

“…The HSP60/HSP10 chaperonin assists folding of proteins in the mitochondrial matrix space by enclosing them in its central cavity. The chaperonin forms part of…”
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From proteome lists to biological impact- tools and strategies for the analysis of large MS data sets by Malik, Rainer, Dulla, Kalyan, Nigg, Erich A, Körner, Roman

“…MS has become a method-of-choice for proteome analysis, generating large data sets, which reflect proteome-scale protein-protein interaction and PTM networks…”
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A GRASP55-Rab2 Effector Complex Linking Golgi Structure to Membrane Traffic by Short, Benjamin, Preisinger, Christian, Körner, Roman, Kopajtich, Robert, Byron, Olwyn, Barr, Francis A.

“…Membrane traffic between the endoplasmic reticulum (ER) and Golgi apparatus and through the Golgi apparatus is a highly regulated process controlled by members…”
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Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1 by Dou, Zhen, von Schubert, Conrad, Körner, Roman, Santamaria, Anna, Elowe, Sabine, Nigg, Erich A

“…Members of the Mps1 kinase family play an essential and evolutionarily conserved role in the spindle assembly checkpoint (SAC), a surveillance mechanism that…”
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SUMO modification of the ubiquitin-conjugating enzyme E2-25K by Pichler, Andrea, Sixma, Titia K, Knipscheer, Puck, Oberhofer, Edith, van Dijk, Willem J, Körner, Roman, Olsen, Jesper Velgaard, Jentsch, Stefan, Melchior, Frauke

“…Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and…”
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Proteome Analysis of the Human Mitotic Spindle by Sauer, Guido, Körner, Roman, Hanisch, Anja, Ries, Albert, Nigg, Erich A, Silljé, Herman H W

“…The accurate distribution of sister chromatids during cell division is crucial for the generation of two cells with the same complement of genetic information…”
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Absorption coefficients of GeSn extracted from PIN photodetector response by Ye, Kaiheng, Zhang, Wogong, Oehme, Michael, Schmid, Marc, Gollhofer, Martin, Kostecki, Konrad, Widmann, Daniel, Körner, Roman, Kasper, Erich, Schulze, Jörg

“…In this paper the optical absorption of the GeSn PIN photodetector was investigated. The vertical GeSn PIN photodetectors were fabricated by molecular beam…”
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