Search Results - "Kölbel, Knut"
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Subtleties in Clathrin heavy chain binding boxes provide selectivity among adaptor proteins of budding yeast
Published in Nature communications (07-11-2024)“…Clathrin forms a triskelion, or three-legged, network that regulates cellular processes by facilitating cargo internalization and trafficking in eukaryotes…”
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Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes
Published in PloS one (11-11-2014)“…We describe the detailed structural investigation of nidogen-1/laminin γ1 complexes using full-length nidogen-1 and a number of laminin γ1 variants. The…”
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Nonconserved Ca2+/Calmodulin Binding Sites in Munc13s Differentially Control Synaptic Short-Term Plasticity
Published in Molecular and Cellular Biology (01-11-2012)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Monitoring Conformational Changes in Peroxisome Proliferator-Activated Receptor α by a Genetically Encoded Photoamino Acid, Cross-Linking, and Mass Spectrometry
Published in Journal of medicinal chemistry (13-06-2013)“…Chemical cross-linking combined with an enzymatic digestion and mass spectrometric analysis of the reaction products has evolved into an alternative strategy…”
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Peptide Backbone Conformation Affects the Substrate Preference of Protein Arginine Methyltransferase I
Published in Biochemistry (Easton) (10-07-2012)“…Asymmetric dimethylation of arginine side chains is a common post-translational modification of eukaryotic proteins, which serves mostly to regulate…”
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Structural Insights into Retinal Guanylylcyclase–GCAP-2 Interaction Determined by Cross-Linking and Mass Spectrometry
Published in Biochemistry (Easton) (19-06-2012)“…The retinal guanylylcyclases ROS-GC 1 and 2 are regulated via the intracellular site by guanylylcyclase-activating proteins (GCAPs). The mechanisms of how…”
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NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV‑2 Spike Protein Receptor-Binding Domain
Published in Journal of the American Chemical Society (27-07-2022)“…We have used chemical shift perturbation (CSP) and saturation transfer difference (STD) NMR experiments to identify and characterize the binding of selected…”
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Further insights from structural mass spectrometry into endocytosis adaptor protein assemblies
Published in International journal of mass spectrometry (01-01-2020)“…As a fundament in many biologically relevant processes, endocytosis in its different guises has been arousing interest for decades and still does so. This is…”
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Analysis of Peptide Secondary Structures by Photoactivatable Amino Acid Analogues
Published in Angewandte Chemie International Edition (07-12-2012)“…Photochemical cross‐linking was applied to trap intramolecular interactions in peptides. The incorporation of diazirine‐labeled amino acid analogues in…”
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Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity
Published in Molecular and cellular biology (01-11-2012)“…Munc13s are presynaptic proteins that mediate synaptic vesicle priming and thereby control the size of the readily releasable pool of vesicles. During high…”
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Native state dynamics affects the folding transition of porcine pancreatic phospholipase A2
Published in Biophysical chemistry (01-11-2015)“…Porcine pancreatic phospholipase A2, a small and disulfide rich protein, is extremely resistant against chemically or thermally induced unfolding. Despite this…”
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Analysis of Nidogen-1/Laminin [gamma]1 Interaction by Cross-Linking, Mass Spectrometry, and Computational Modeling Reveals Multiple Binding Modes
Published in PloS one (11-11-2014)“…We describe the detailed structural investigation of nidogen-1/laminin [gamma]1 complexes using full-length nidogen-1 and a number of laminin [gamma]1…”
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Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively
Published in The Journal of biological chemistry (27-03-2009)“…Asymmetric dimethylation of arginine residues is a common posttranslational modification of proteins carried out by type I protein arginine methyltransferases,…”
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Analyse von Sekundärstrukturen in Peptiden mithilfe photoaktivierbarer Aminosäureanaloga
Published in Angewandte Chemie (07-12-2012)“…Photochemische Quervernetzung diente zur Fixierung intramolekularer Kontakte in Peptiden (siehe Bild). Der Einbau Diazirin‐markierter Aminosäureanaloga in…”
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Promiscuous Modification of the Nuclear Poly(A)-binding Protein by Multiple Protein-arginine Methyltransferases Does Not Affect the Aggregation Behavior
Published in The Journal of biological chemistry (18-07-2008)“…The mammalian nuclear poly(A)-binding protein, PABPN1, carries 13 asymmetrically dimethylated arginine residues in its C-terminal domain. By fractionation of…”
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Conformational Shift of a β‐Hairpin Peptide upon Complex Formation with an Oligo–proline Peptide Studied by Mass Spectrometry
Published in ChemistrySelect (Weinheim) (16-08-2016)“…So‐called super‐secondary structures such as the β‐hairpin, studied here, form an intermediate hierarchy between secondary and tertiary structures of proteins…”
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Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act DistributivelyS
Published in The Journal of biological chemistry (27-03-2009)“…Asymmetric dimethylation of arginine residues is a common posttranslational modification of proteins carried out by type I protein arginine methyltransferases,…”
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Nonconserved Ca 2+ /Calmodulin Binding Sites in Munc13s Differentially Control Synaptic Short-Term Plasticity
Published in Molecular and cellular biology (01-11-2012)Get full text
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Analyse von Sekundärstrukturen in Peptiden mithilfe photoaktivierbarer Aminosäureanaloga
Published in Angewandte Chemie (07-12-2012)Get full text
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