Search Results - "Köhr, G."

Spike‐timing‐dependent plasticity in hippocampal CA3 neurons by Astori, S., Pawlak, V., Köhr, G.

“…Synaptic plasticity of different inputs converging onto CA3 pyramidal neurons is central to theories of hippocampal function. The mossy fibre (MF) input to…”
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Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family by Kohr, G, Seeburg, P H

“…1. Tyrosine kinases regulate NMDA receptor-channel activity in cultured neurons, and NMDA receptor subunits are tyrosine phosphorylated in the brain. 2…”
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The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family by Lomeli, H., Sprengel, R., Laurie, D.J., Köhr, G., Herb, A., Seeburg, P.H., Wisden, W.

“…We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of…”
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P02-44 - C-Fos brain mapping of global and subunit-specific NMDA receptor antagonists: Relevance for their potential use as antidepressants by Inta, D, Lima, J, Filipovic, D, Köhr, G, Sprengel, R, Gass, P

“…Introduction NMDA receptor antagonists as ketamine represent fast-acting alternatives to monoaminergic-based antidepressants. Major drawbacks of these drugs…”
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NMDA receptor channels: subunit-specific potentiation by reducing agents by Köhr, G, Eckardt, S, Lüddens, H, Monyer, H, Seeburg, P H

“…Sulfhydryl redox agents affect NMDA receptor activity. We investigated a putative redox site in four recombinant NMDA receptors. In 293 cells expressing…”
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Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats by Kohr, G, De Koninck, Y, Mody, I

“…The hyperexcitability accompanying chronic epileptiform activity may result from long-term alterations of ligand- and voltage-gated channels. Previous studies…”
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Kindling increases N-methyl-D-aspartate potency at single N-methyl-D-aspartate channels in dentate gyrus granule cells by Köhr, G, Mody, I

“…Dose-response studies of N-methyl-D-aspartate channel openings were carried out using cell-attached patches in dentate gyrus granule cells acutely isolated…”
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Trace-order and a distortion theorem for linearly invariant families on the unit ball of a finite dimensional JB∗ -triple by Hamada, H., Honda, T., Kohr, G.

“…We give a distortion theorem for linearly invariant families on the unit ball B of a finite dimensional JB∗-triple X by using the trace-order. The exponents in…”
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Phasic Dopamine Modifies Sensory-Driven Output of Striatal Neurons through Synaptic Plasticity by Wieland, Sebastian, Schindler, Sebastian, Huber, Cathrin, Köhr, Georg, Oswald, Manfred J, Kelsch, Wolfgang

“…Animals are facing a complex sensory world in which only few stimuli are relevant to guide behavior. Value has to be assigned to relevant stimuli such as odors…”
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Distortion theorems for convex mappings on homogeneous balls by Chu, C.-H., Hamada, H., Honda, T., Kohr, G.

“…Let B be the open unit ball of a complex Banach space X and let B be homogeneous. We prove distortion results for normalized convex mappings f : B → X which…”
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NR2A subunit of the N-methyl d -aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning by Andreescu, C.E, Prestori, F, Brandalise, F, D'Errico, A, De Jeu, M.T.G, Rossi, P, Botta, L, Kohr, G, Perin, P, D'Angelo, E, De Zeeuw, C.I

“…Abstract Traditionally studies aimed at elucidating the molecular mechanisms underlying cerebellar motor learning have been focused on plasticity at the…”
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D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1 by Herwerth, Marina, Jensen, Vidar, Novak, Martin, Konopka, Witold, Hvalby, Oivind, Köhr, Georg

“…Dopamine plays an important role in synaptic plasticity and learning and is involved in the pathogenesis of various neurological and psychiatric disorders…”
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Endogenous intracellular calcium buffering and the activation/inactivation of HVA calcium currents in rat dentate gyrus granule cells by KÖHR, G, MODY, I

“…Granule cells acutely dissociated from the dentate gyrus of adult rat brains displayed a single class of high-threshold, voltage-activated (HVA) Ca2+ channels…”
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Calbindin-D28K (CaBP) levels and calcium currents in acutely dissociated epileptic neurons by KOHR, G, LAMBERT, C. E, MODY, I

“…Nerve cells that lack the cytoplasmic Ca2+ binding protein Calbindin-D28K (CaBP) appear to be selectively vulnerable to Ca(2+)-related injury consistent with a…”
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Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices by Köhr, G, Heinemann, U

“…The effects of members of a new class of anticonvulsants, the tetronic acid derivatives, were studied in 3 in vitro models of epileptogenesis in rat…”
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C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors by Steigerwald, Frank, Schulz, Torsten W, Schenker, Leslie T, Kennedy, Mary B, Seeburg, Peter H, Kohr, Georg

“…NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of…”
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Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor by Osten, P, Khatri, L, Perez, J L, Köhr, G, Giese, G, Daly, C, Schulz, T W, Wensky, A, Lee, L M, Ziff, E B

“…We studied the role of PDZ proteins GRIP, ABP, and PICK1 in GluR2 AMPA receptor trafficking. An epitope-tagged MycGluR2 subunit, when expressed in hippocampal…”
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Anticonvulsant effects of tetronic acid derivatives on picrotoxin induced epileptiform activity in rat hippocampal slices by Köhr, G, Heinemann, U

“…We have investigated the effects of a new class of anticonvulsants, the tetronic acid derivatives AO33 (generic name: losigame) and AO78, on field potentials,…”
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Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum by Köhr, Georg, Melcher, Thorsten, Seeburg, Peter H

“…RNA editing by site selective adenosine deamination changes codons in several nuclear transcripts in the mammalian brain and affects critical properties of the…”
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The balance between excitation and inhibition in dentate granule cells and its role in epilepsy by Mody, I, Otis, T S, Staley, K J, Köhr, G

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