Search Results - "Köhnke, Thomas"

Clonal Hematopoiesis: From Mechanisms to Clinical Intervention by Köhnke, Thomas, Majeti, Ravindra

“…Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown vastly over the past years, touching upon many specialties beyond…”
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Recent developments in immunotherapy of acute myeloid leukemia by Lichtenegger, Felix S, Krupka, Christina, Haubner, Sascha, Köhnke, Thomas, Subklewe, Marion

“…The advent of new immunotherapeutic agents in clinical practice has revolutionized cancer treatment in the past decade, both in oncology and hematology. The…”
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Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia by Zhang, Haijiao, Nakauchi, Yusuke, Köhnke, Thomas, Stafford, Melissa, Bottomly, Daniel, Thomas, Rozario, Wilmot, Beth, McWeeney, Shannon K, Majeti, Ravindra, Tyner, Jeffrey W

“…Deregulation of the gene family plays an important role in the pathogenesis of acute myeloid leukemia (AML). The BCL2 inhibitor, venetoclax, has received FDA…”
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Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab by Köhnke, Thomas, Krupka, Christina, Tischer, Johanna, Knösel, Thomas, Subklewe, Marion

“…The bispecific T cell engager blinatumomab has shown encouraging clinical activity in B-precursor acute lymphoblastic leukemia (ALL). However, about half of…”
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Diagnosis of CLL revisited: increased specificity by a modified five‐marker scoring system including CD200 by Köhnke, Thomas, Wittmann, Veronika K., Bücklein, Veit L., Lichtenegger, Felix, Pasalic, Zlatana, Hiddemann, Wolfgang, Spiekermann, Karsten, Subklewe, Marion

“…Summary The modified Matutes score has been the basis for the diagnosis of chronic lymphocytic leukaemia (CLL) by flow cytometry for the past 15 years. To…”
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Data mining for mutation-specific targets in acute myeloid leukemia by Benard, Brooks, Gentles, Andrew J., Köhnke, Thomas, Majeti, Ravindra, Thomas, Daniel

“…Three mutation-specific targeted therapies have recently been approved by the FDA for the treatment of acute myeloid leukemia (AML): midostaurin for FLT3…”
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Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia by Rothenberg-Thurley, Maja, Amler, Susanne, Goerlich, Dennis, Köhnke, Thomas, Konstandin, Nikola P., Schneider, Stephanie, Sauerland, Maria C., Herold, Tobias, Hubmann, Max, Ksienzyk, Bianka, Zellmeier, Evelyn, Bohlander, Stefan K., Subklewe, Marion, Faldum, Andreas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten, Metzeler, Klaus H.

“…Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a…”
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Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2 by Dutta, Ritika, Zhang, Tian Yi, Köhnke, Thomas, Thomas, Daniel, Linde, Miles, Gars, Eric, Stafford, Melissa, Kaur, Satinder, Nakauchi, Yusuke, Yin, Raymond, Azizi, Armon, Narla, Anupama, Majeti, Ravindra

“…Cancer-related anemia is present in more than 60% of newly diagnosed cancer patients and is associated with substantial morbidity and high medical costs. Drugs…”
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RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition by Fan, Amy C, Nakauchi, Yusuke, Bai, Lawrence, Nuno, Armon Aziz Kevin A, Kohnke, 3.Feifei Zhao Thomas, Karigane, Daiki, Cruz-Hernandez, David, Reinisch, Andreas, Khatri, Purvesh, Majet, Ravindra

“…Disease-initiating mutations in the transcription factor RUNX1 occur as germline and somatic events that cause leukemias with particularly poor prognosis…”
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The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells by Sharma, Rajiv, Dever, Daniel P., Lee, Ciaran M., Azizi, Armon, Pan, Yidan, Camarena, Joab, Köhnke, Thomas, Bao, Gang, Porteus, Matthew H., Majeti, Ravindra

“…Targeted DNA correction of disease-causing mutations in hematopoietic stem and progenitor cells (HSPCs) may enable the treatment of genetic diseases of the…”
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Single-cell mutational profiling enhances the clinical evaluation of AML MRD by Ediriwickrema, Asiri, Aleshin, Alexey, Reiter, Johannes G., Corces, M. Ryan, Köhnke, Thomas, Stafford, Melissa, Liedtke, Michaela, Medeiros, Bruno C., Majeti, Ravindra

“…Although most patients with acute myeloid leukemia (AML) achieve clinical remission with induction chemotherapy, relapse rates remain high. Next-generation…”
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Virus infection in HLA-haploidentical hematopoietic stem cell transplantation: incidence in the context of immune recovery in two different transplantation settings by Tischer, Johanna, Engel, Nicole, Fritsch, Susanne, Prevalsek, Dusan, Hubmann, Max, Schulz, Christoph, Zoellner, Anna-K., Bücklein, Veit, Reibke, Roland, Mumm, Friederike, Rieger, Christina T., Hill, Wolfgang, Ledderose, Georg, Stemmler, Hans Joachim, Köhnke, Thomas, Jäger, Gundula, Kolb, Hans Jochem, Schmid, Christoph, Moosmann, Andreas, Hausmann, Andreas

“…We retrospectively compared the incidence of virus infections and outcome in the context of immune reconstitution in two different HLA-haploidentical…”
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A Role for Lipid Mediators in Acute Myeloid Leukemia by Loew, Andreas, Köhnke, Thomas, Rehbeil, Emma, Pietzner, Anne, Weylandt, Karsten-H

“…In spite of therapeutic improvements in the treatment of different hematologic malignancies, the prognosis of acute myeloid leukemia (AML) treated solely with…”
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IDH1-mutant preleukemic hematopoietic stem cells can be eliminated by inhibition of oxidative phosphorylation by Landberg, Niklas, Köhnke, Thomas, Feng, Yang, Nakauchi, Yusuke, Fan, Amy C, Linde, Miles H, Karigane, Daiki, Lim, Kelly, Sinha, Rahul, Malcovati, Luca, Thomas, Daniel, Majeti, Ravindra

“…Rare preleukemic hematopoietic stem cells (pHSCs) harboring only the initiating mutations can be detected at the time of AML diagnosis. pHSCs are the origin of…”
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Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse by Hubmann, Max, Köhnke, Thomas, Hoster, Eva, Schneider, Stephanie, Dufour, Annika, Zellmeier, Evelyn, Fiegl, Michael, Braess, Jan, Bohlander, Stefan K, Subklewe, Marion, Sauerland, Maria-Cristina, Berdel, Wolfgang E, Büchner, Thomas, Wörmann, Bernhard, Hiddemann, Wolfgang, Spiekermann, Karsten

“…Monitoring minimal residual disease is an important way to identify patients with acute myeloid leukemia at high risk of relapse. In this study we investigated…”
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Response assessment in acute myeloid leukemia by flow cytometry supersedes cytomorphology at time of aplasia, amends cases without molecular residual disease marker and serves as an independent prognostic marker at time of aplasia and post-induction by Köhnke, Thomas, Bücklein, Veit, Rechkemmer, Sandra, Schneider, Stephanie, Rothenberg-Thurley, Maja, Metzeler, Klaus H, Sauerland, Maria-Cristina, Hiddemann, Wolfgang, Spiekermann, Karsten, Subklewe, Marion

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The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia by Nakauchi, Yusuke, Azizi, Armon, Thomas, Daniel, Corces, M Ryan, Reinisch, Andreas, Sharma, Rajiv, Cruz Hernandez, David, Köhnke, Thomas, Karigane, Daiki, Fan, Amy, Martinez-Krams, Daniel, Stafford, Melissa, Kaur, Satinder, Dutta, Ritika, Phan, Paul, Ediriwickrema, Asiri, McCarthy, Erin, Ning, Yuhong, Phillips, Tierney, Ellison, Christopher K, Guler, Gulfem D, Bergamaschi, Anna, Ku, Chin-Jen, Levy, Samuel, Majeti, Ravindra

“…The conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is a key step in DNA demethylation that is mediated by ten-eleven translocation…”
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Integrated multiomic approach for identification of novel immunotherapeutic targets in AML by Köhnke, Thomas, Liu, Xilong, Haubner, Sascha, Bücklein, Veit, Hänel, Gerulf, Krupka, Christina, Solis-Mezarino, Victor, Herzog, Franz, Subklewe, Marion

“…Immunotherapy of acute myeloid leukemia has experienced considerable advances, however novel target antigens continue to be sought after. To this end, unbiased…”
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Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators by Weylandt, Karsten H., Rothe, Michael, Sun, Y., Zhou, Xiangzhi, Bilal, Süleyman, Gomolka, Beate, Köhnke, Thomas, Baumgart, Daniel C.

“…The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation…”
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Quantitative Monitoring of NPM1 Mutation A Minimal Residual Disease Identifies Patients At High Risk for Relapse within the ELN Favorable Risk Group by Hubmann, Max, Subklewe, Marion, Köhnke, Thomas, Schneider, Stephanie, Dufour, Annika, Zellmeier, Evelyn, Fiegl, Michael, Hiddemann, Wolfgang, Spiekermann, Karsten

“…Abstract 1404▪▪This icon denotes a clinically relevant abstract Molecular analyses of leukemia-specific markers has led to an improvement of the prognosis…”
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