Search Results - "Köhnke, Michael D"

ASSOCIATION OF THE DOPAMINE TRANSPORTER GENE WITH ALCOHOLISM by KÖHNKE, MICHAEL D., BATRA, ANIL, KOLB, WERNER, KÖHNKE, ANNETTE M., LUTZ, ULRICH, SCHICK, SANDRA, GAERTNER, INES

“…Aims: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol…”
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Approach to the genetics of alcoholism: A review based on pathophysiology by Koehnke, Michael D

“…Alcohol dependence is a common disorder with a heterogenous etiology. The results of family, twin and adoption studies on alcoholism are reviewed. These…”
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Significant impact of MTHFR C677T polymorphism on plasma homovanillic acid (HVA) levels among alcohol-dependent patients by Lutz, Ulrich C, Batra, Anil, Wiatr, Gerlinde, Machicao, Fausto, Kolb, Werner, Maurer, Sandra, Buchkremer, Gerhard, Köhnke, Michael D

“…The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate. It plays a critical role in homocysteine metabolism. A high…”
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A Single Nucleotide Polymorphism at DBH, Possibly Associated with Attention-Deficit/Hyperactivity Disorder, Associates with Lower Plasma Dopamine β-Hydroxylase Activity and is in Linkage Disequilibrium with Two Putative Functional Single Nucleotide Polymorphisms by Tang, Yilang, Buxbaum, Sarah G., Waldman, Irwin, Anderson, George M., Zabetian, Cyrus P., Köhnke, Michael D., Cubells, Joseph F.

“…The DBH gene regulates plasma dopamine β-hydroxylase activity (pDβH). Two single nucleotide polymorphisms (SNPs), −1021C→T (rs1611115; SNP1) and +1603C→T…”
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Methylenetetrahydrofolate Reductase C677T-Polymorphism and Its Association With Alcohol Withdrawal Seizure by Lutz, Ulrich C., Batra, Anil, Kolb, Werner, Machicao, Fausto, Maurer, Sandra, Köhnke, Michael D.

“…Background: Elevated homocysteine plasma levels are considered as a risk factor for the occurrence of seizures during alcohol withdrawal. Homocysteine plasma…”
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A genotype-controlled analysis of plasma dopamine β-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function by Köhnke, Michael D, Zabetian, Cyrus P, Anderson, George M, Kolb, Werner, Gaertner, Ines, Buchkremer, Gerhard, Vonthein, Reinhard, Schick, Sandra, Lutz, Ulrich, Köhnke, Annette M, Cubells, Joseph F

“…Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-β-hydroxylase (DβH) converts dopamine to norepinephrine. A…”
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The Structure of Linkage Disequilibrium at the DBH Locus Strongly Influences the Magnitude of Association between Diallelic Markers and Plasma Dopamine β-Hydroxylase Activity by Zabetian, Cyrus P., Buxbaum, Sarah G., Elston, Robert C., Köhnke, Michael D., Anderson, George M., Gelernter, Joel, Cubells, Joseph F.

“…There is currently a great deal of interest in using linkage disequilibrium (LD) mapping to locate both disease and quantitative-trait loci on a genomewide…”
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The serotonin transporter promotor polymorphism 5-HTTLPR is not associated with alcoholism or severe forms of alcohol withdrawal in a German sample by Köhnke, Michael D, Kolb, Werner, Lutz, Ulrich, Maurer, Sandra, Batra, Anil

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Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C → T) with plasma dopamine β-hydroxylase activity by Tang, Yilang, Anderson, George M., Zabetian, Cyrus P., Köhnke, Michael D., Cubells, Joseph F.

“…The DBH locus controls plasma dopamine β‐hydroxylase activity (pDβH). A 5′‐upstream single nucleotide polymorphism (SNP) at DBH (−1021C → T) explains ∼45% of…”
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Allele distribution of a monoamine oxidase A gene promoter polymorphism in German alcoholics and in subgroups with severe forms of alcohol withdrawal and its influence on plasma homovanillic acid by Köhnke, Michael D, Lutz, Ulrich, Kolb, Werner, Maurer, Sandra, Wiatr, Gerlinde, Batra, Anil

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Cytochrome P450 2D6 dependent metabolization of risperidone is inhibited by melperone by Köhnke, Michael D, Lutz, Ulrich, Wiatr, Gerlinde, Schwärzler, Frank, Weller, Bastian, Schott, Klaus, Buchkremer, Gerhard

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A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T → C in African- and European-Americans by Zabetian, Cyrus P., Romero, Roberto, Robertson, David, Sharma, Surendra, Padbury, James F., Kuivaniemi, Helena, Kim, Kwang-Soo, Kim, Chun-Hyung, Köhnke, Michael D., Kranzler, Henry R., Gelernter, Joel, Cubells, Joseph F.

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Approach to the genetics of alcoholism : A review based on pathophysiology: Drug addiction by KÖHNKE, Michael D

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Plasma homovanillic acid: A significant association with alcoholism is independent of a functional polymorphism of the human catechol-O-methyltransferase gene by KÖHNKE, Michael D, WIATR, Gerlinde, KOLB, Werner, KÖHNKE, Annette M, SCHICK, Sandra, LUTZ, Ulrich, VONTHEIN, Reinhard, GAERTNER, Ines

“…The central dopamine system seems to influence addictive disorders. Plasma homovanillic acid (HVA) is an indicator of central dopaminergic activity. In this…”
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GENETIC STUDY: Significant impact of MTHFR C677T polymorphism on plasma homovanillic acid (HVA) levels among alcohol-dependent patients by Lutz, Ulrich C., Batra, Anil, Wiatr, Gerlinde, Machicao, Fausto, Kolb, Werner, Maurer, Sandra, Buchkremer, Gerhard, Köhnke, Michael D.

“…ABSTRACT The enzyme 5,10‐methylenetetrahydrofolate reductase (MTHFR) synthesizes 5‐methyltetrahydrofolate. It plays a critical role in homocysteine metabolism…”
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Central pontine myelinolysis in a normonatraemic alcoholic patient by MUNDLE, GÖTZ, FRIESE, SIGRID, KÖHNKE, MICHAEL D.

“…Central pontine myelinolysis (CPM) is a rare disease which has been associated with hyponatraemia and its rapid correction. We describe a malnourished…”
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Central pontine myelinolysis in a normonatraemic alcoholic patient by MUNDLE, GÖTZ, FRIESE, SIGRID, KÖHNKE, MICHAEL D.

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Cytochrome P450 2D6 dependent metabolization of risperidone is inhibited by melperone by Köhnke, Michael D, Lutz, Ulrich, Wiatr, Gerlinde, Schwärzler, Frank, Weller, Bastian, Schott, Klaus, Buchkremer, Gerhard

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