Search Results - "Köhler, Thilo"

Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture by Tognon, Mikaël, Köhler, Thilo, Luscher, Alexandre, van Delden, Christian

“…Co-colonization by Pseudomonas aeruginosa and Staphylococcus aureus is frequent in cystic fibrosis patients. Polymicrobial infections involve both detrimental…”
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Machine learning designs non-hemolytic antimicrobial peptides by Capecchi, Alice, Cai, Xingguang, Personne, Hippolyte, Köhler, Thilo, van Delden, Christian, Reymond, Jean-Louis

“…Machine learning (ML) consists of the recognition of patterns from training data and offers the opportunity to exploit large structure-activity databases for…”
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Lipidated Peptide Dendrimers Killing Multidrug-Resistant Bacteria by Siriwardena, Thissa N, Stach, Michaela, He, Runze, Gan, Bee-Ha, Javor, Sacha, Heitz, Marc, Ma, Lan, Cai, Xiangju, Chen, Peng, Wei, Dengwen, Li, Hongtao, Ma, Jun, Köhler, Thilo, van Delden, Christian, Darbre, Tamis, Reymond, Jean-Louis

“…New antibiotics are urgently needed to address multidrug-resistant (MDR) bacteria. Herein we report that second-generation (G2) peptide dendrimers bearing a…”
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TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates by Luscher, Alexandre, Moynié, Lucile, Auguste, Pamela Saint, Bumann, Dirk, Mazza, Lena, Pletzer, Daniel, Naismith, James H, Köhler, Thilo

“…The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria…”
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To Fold or Not to Fold: Diastereomeric Optimization of an α‑Helical Antimicrobial Peptide by Personne, Hippolyte, Paschoud, Thierry, Fulgencio, Sofia, Baeriswyl, Stéphane, Köhler, Thilo, van Delden, Christian, Stocker, Achim, Javor, Sacha, Reymond, Jean-Louis

“…Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address multidrug resistance; however, most AMPs are toxic and unstable in…”
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Stereorandomized Oncocins with Preserved Ribosome Binding and Antibacterial Activity by Gan, Bee Ha, Bonvin, Etienne, Paschoud, Thierry, Personne, Hippolyte, Reusser, Jérémie, Cai, Xingguang, Rauscher, Robert, Köhler, Thilo, van Delden, Christian, Polacek, Norbert, Reymond, Jean-Louis

“…We recently showed that solid-phase peptide synthesis using racemic amino acids yields stereorandomized peptides comprising all possible diastereomers as…”
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Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii by Moynié, Lucile, Luscher, Alexandre, Rolo, Dora, Pletzer, Daniel, Tortajada, Antoni, Weingart, Helge, Braun, Yvonne, Page, Malcolm G P, Naismith, James H, Köhler, Thilo

“…The outer membrane of Gram-negative bacteria presents an efficient barrier to the permeation of antimicrobial molecules. One strategy pursued to circumvent…”
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Antibiotic resistant Pseudomonas spp. in the aquatic environment: A prevalence study under tropical and temperate climate conditions by Devarajan, Naresh, Köhler, Thilo, Sivalingam, Periyasamy, van Delden, Christian, Mulaji, Crispin K., Mpiana, Pius T., Ibelings, Bastiaan W., Poté, John

“…Microbial populations which are resistant to antibiotics are an emerging environmental concern with potentially serious implications for public health. Thus,…”
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The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4 by Cai, Xingguang, Javor, Sacha, Gan, Bee Ha, Köhler, Thilo, Reymond, Jean-Louis

“…pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA)…”
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Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa by Stach, Michaela, Siriwardena, Thissa N., Köhler, Thilo, van Delden, Christian, Darbre, Tamis, Reymond, Jean-Louis

“…Multidrug‐resistant opportunistic bacteria, such as Pseudomonas aeruginosa, represent a major public health threat. Antimicrobial peptides (AMPs) and related…”
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Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa by Köhler, Thilo, Luscher, Alexandre, Falconnet, Léna, Resch, Grégory, McBride, Robert, Mai, Quynh-Anh, Simonin, Juliette L., Chanson, Marc, Maco, Bohumil, Galiotto, Raphaël, Riat, Arnaud, Civic, Natacha, Docquier, Mylène, McCallin, Shawna, Chan, Benjamin, van Delden, Christian

“…Bacteriophage therapy has been suggested as an alternative or complementary strategy for the treatment of multidrug resistant (MDR) bacterial infections. Here,…”
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Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria by Gan, Bee-Ha, Cai, Xingguang, Javor, Sacha, Köhler, Thilo, Reymond, Jean-Louis

“…There is an urgent need to develop new antibiotics against multidrug-resistant bacteria. Many antimicrobial peptides (AMPs) are active against such bacteria…”
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Cooperation and virulence of clinical Pseudomonas aeruginosa populations by Köhler, Thilo, Buckling, Angus, van Delden, Christian

“…Bacteria communicate and cooperate to perform a wide range of social behaviors including production of extracellular products (public goods) that are crucial…”
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Quorum sensing inhibition selects for virulence and cooperation in Pseudomonas aeruginosa by Köhler, Thilo, Perron, Gabriel G, Buckling, Angus, van Delden, Christian

“…With the rising development of bacterial resistance the search for new medical treatments beyond conventional antimicrobials has become a key aim of public…”
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Co-evolution with Staphylococcus aureus leads to lipopolysaccharide alterations in Pseudomonas aeruginosa by Tognon, Mikael, Köhler, Thilo, Gdaniec, Bartosz G, Hao, Youai, Lam, Joseph S, Beaume, Marie, Luscher, Alexandre, Buckling, Angus, van Delden, Christian

“…Detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. In cystic fibrosis (CF) airways, Staphylococcus…”
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Lipopolysaccharide as Shield and Receptor for R-Pyocin-Mediated Killing in Pseudomonas aeruginosa by Köhler, Thilo, Donner, Viviane, van Delden, Christian

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Susceptibility profiles and resistance genomics of Pseudomonas aeruginosa isolates from European ICUs participating in the ASPIRE-ICU trial by Torrens, Gabriel, van der Schalk, Thomas Ewout, Cortes-Lara, Sara, Timbermont, Leen, del Barrio-Tofiño, Ester, Xavier, Basil Britto, Zamorano, Laura, Lammens, Christine, Ali, Omar, Ruzin, Alexey, Goossens, Herman, Kumar-Singh, Samir, Kluytmans, Jan, Paling, Fleur, MacLean, R Craig, Köhler, Thilo, López-Causapé, Carla, Malhotra-Kumar, Surbhi, Oliver, Antonio

“…Abstract Objectives To determine the susceptibility profiles and the resistome of Pseudomonas aeruginosa isolates from European ICUs during a prospective…”
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Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms by Di Bonaventura, Ivan, Jin, Xian, Visini, Ricardo, Probst, Daniel, Javor, Sacha, Gan, Bee-Ha, Michaud, Gaëlle, Natalello, Antonino, Doglia, Silvia Maria, Köhler, Thilo, van Delden, Christian, Stocker, Achim, Darbre, Tamis, Reymond, Jean-Louis

“…Herein we report the discovery of antimicrobial bridged bicyclic peptides (AMBPs) active against , a highly problematic Gram negative bacterium in the hospital…”
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Pyomelanin-producing Pseudomonas aeruginosa selected during chronic infections have a large chromosomal deletion which confers resistance to pyocins by Hocquet, Didier, Petitjean, Marie, Rohmer, Laurence, Valot, Benoît, Kulasekara, Hemantha D., Bedel, Elodie, Bertrand, Xavier, Plésiat, Patrick, Köhler, Thilo, Pantel, Alix, Jacobs, Michael A., Hoffman, Lucas R., Miller, Samuel I.

“…Summary When bacterial lineages make the transition from free‐living to permanent association with hosts, they can undergo massive gene losses, for which the…”
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Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns by Jafari, Paris, Luscher, Alexandre, Siriwardena, Thissa, Michetti, Murielle, Que, Yok-Ai, Rahme, Laurence G., Reymond, Jean-Louis, Raffoul, Wassim, Van Delden, Christian, Applegate, Lee Ann, Köhler, Thilo

“…Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for…”
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