Search Results - "Köhler, Jens"

Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance by Rose, Jonas C, Cámara-Torres, María, Rahimi, Khosrow, Köhler, Jens, Möller, Martin, De Laporte, Laura

“…Injectable biomaterials provide the advantage of a minimally invasive application but mostly lack the required structural complexity to regenerate aligned…”
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Hydrophobic Interaction within Sparsely N‑Alkylated Poly(N‑vinylacetamide)s Enables Versatile Formation of Reversible Hydrogels by Zhang, Chunchen, Demco, Dan Eugen, Rimal, Rahul, Köhler, Jens, Vinokur, Rostislav, Singh, Smriti, Tenbusch, Jan, Möller, Martin

“…We demonstrate reversible hydrogel formation by hydrophobic interaction for poly­(N-alkyl-N-vinylacetamide)­s with 3 mol % of alkyl chains (side chain length =…”
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Cellular responses to beating hydrogels to investigate mechanotransduction by Chandorkar, Yashoda, Castro Nava, Arturo, Schweizerhof, Sjören, Van Dongen, Marcel, Haraszti, Tamás, Köhler, Jens, Zhang, Hang, Windoffer, Reinhard, Mourran, Ahmed, Möller, Martin, De Laporte, Laura

“…Cells feel the forces exerted on them by the surrounding extracellular matrix (ECM) environment and respond to them. While many cell fate processes are…”
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Enantiomerically Pure 1,3-Dioxanes as Highly Selective NMDA and σ1 Receptor Ligands by Köhler, Jens, Bergander, Klaus, Fabian, Jörg, Schepmann, Dirk, Wünsch, Bernhard

“…We synthesized and investigated the NMDA and σ1 receptor affinity of enantiomerically pure 2-(2-phenyl-1,3-dioxan-4-yl)ethanamines 17–26. The primary amines…”
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Targeting the EGF receptor family in non-small cell lung cancer-increased complexity and future perspectives by Boch, Tobias, Köhler, Jens, Janning, Melanie, Loges, Sonja

“…Lung cancer remains the leading cause of cancer-associated mortality worldwide, but with the emergence of oncogene targeted therapies, treatment options have…”
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Physical gels of poly(vinylamine) by thermal curing by Fischer, Thorsten, Köhler, Jens, Möller, Martin, Singh, Smriti

“…Physical gels are a versatile class of materials which can find application in sensors, electrochemistry, biomedicine or rheological modifiers. Herein, we…”
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Insights into Ergochromes of the Plant Pathogen Claviceps purpurea by Lünne, Friederike, Köhler, Jens, Stroh, Christina, Müller, Lena, Daniliuc, Constantin G, Mück-Lichtenfeld, Christian, Würthwein, Ernst-Ulrich, Esselen, Melanie, Humpf, Hans-Ulrich, Kalinina, Svetlana A

“…Claviceps purpurea is an ergot fungus known for its neurotropic alkaloids, which have been identified as the main cause of ergotism, a livestock and human…”
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Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position by Aiello, Daniele, Jonas, Hendrik, Carbone, Anna, Carbone, Daniela, Pecoraro, Camilla, Tesoriere, Luisa, Köhler, Jens, Wünsch, Bernhard, Diana, Patrizia

“…Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their…”
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Development of a highly sensitive and specific method for detection of circulating tumor cells harboring somatic mutations in non-small-cell lung cancer patients by Breitenbuecher, Frank, Hoffarth, Sandra, Worm, Karl, Cortes-Incio, Diana, Gauler, Thomas C, Köhler, Jens, Herold, Thomas, Schmid, Kurt Werner, Freitag, Lutz, Kasper, Stefan, Schuler, Martin

“…Oncogenic mutations are powerful predictive biomarkers for molecularly targeted cancer therapies. For mutation detection patients have to undergo invasive…”
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Correlation of the apparent diffusion coefficient (ADC) with the standardized uptake value (SUV) in lymph node metastases of non-small cell lung cancer (NSCLC) patients using hybrid 18F-FDG PET/MRI by Schaarschmidt, Benedikt Michael, Buchbender, Christian, Nensa, Felix, Grueneisen, Johannes, Grueneien, Johannes, Gomez, Benedikt, Köhler, Jens, Reis, Henning, Ruhlmann, Verena, Umutlu, Lale, Heusch, Philipp

“…To compare the apparent diffusion coefficient (ADC) in lymph node metastases of non-small cell lung cancer (NSCLC) patients with standardized uptake values…”
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Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells by Köhler, Jens, Erlenkamp, German, Eberlin, Adrien, Rumpf, Tobias, Slynko, Inna, Metzger, Eric, Schüle, Roland, Sippl, Wolfgang, Jung, Manfred

“…Epigenetics is defined as heritable changes in gene expression that are not based on changes in the DNA sequence. Posttranslational modification of histone…”
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Manufacturing of functional riblet structures by profile grinding by Denkena, Berend, Köhler, Jens, Wang, Bo

“…In contrast to smooth surfaces, microstructured riblet surfaces can reduce the near-wall shear stresses of a turbulent flow by up to 10%. In the case of…”
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Multilamellar Thermoresponsive Emulsions Stabilized with Biocompatible Semicrystalline Block Copolymers by Manova, Anna, Viktorova, Jekaterina, Köhler, Jens, Theiler, Stefan, Keul, Helmut, Piryazev, Alexey A, Ivanov, Dimitri A, Tsarkova, Larisa, Möller, Martin

“…We demonstrate specific interface-templated crystallization behavior of biocompatible amphiphilic poly­(ethylene oxide)-b-poly­(ε-caprolactone) (PEO-b-PCL)…”
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Hybrid [18 F]-FDG PET/MRI including non-Gaussian diffusion-weighted imaging (DWI): Preliminary results in non-small cell lung cancer (NSCLC) by Heusch, Philipp, Köhler, Jens, Wittsack, Hans-Joerg, Heusner, Till A, Buchbender, Christian, Poeppel, Thorsten D, Nensa, Felix, Wetter, Axel, Gauler, Thomas, Hartung, Verena, Lanzman, Rotem S

“…Abstract Purpose To assess the feasibility of non-Gaussian DWI as part of a FDG-PET/MRI protocol in patients with histologically proven non-small cell lung…”
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Caspase-1 Mediates Resistance in Murine Melioidosis by Breitbach, Katrin, Sun, Guang Wen, Köhler, Jens, Eske, Kristin, Wongprompitak, Patimaporn, Tan, Gladys, Liu, Yichun, Gan, Yunn-Hwen, Steinmetz, Ivo

“…The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical…”
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Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers by Xu, Yue, Zheng, Jie, Cai, Zhaoqing, Li, Wang, Köhler, Jens, Dai, Yao, Cheng, Xiaojie, Wu, Tao, Zhang, Fan, Wang, Haiyun

“…Cancers that are histologically defined as the same type of cancer often need a distinct therapy based on underlying heterogeneity; likewise, histologically…”
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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS by Ambrogio, Chiara, Köhler, Jens, Zhou, Zhi-Wei, Wang, Haiyun, Paranal, Raymond, Li, Jiaqi, Capelletti, Marzia, Caffarra, Cristina, Li, Shuai, Lv, Qi, Gondi, Sudershan, Hunter, John C., Lu, Jia, Chiarle, Roberto, Santamaría, David, Westover, Kenneth D., Jänne, Pasi A.

“…The mechanism by which the wild-type KRAS allele imparts a growth inhibitory effect to oncogenic KRAS in various cancers, including lung adenocarcinoma (LUAD),…”
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Circular Dichroism in the Photoelectron Angular Distributions of Camphor and Fenchone from Multiphoton Ionization with Femtosecond Laser Pulses by Lux, Christian, Wollenhaupt, Matthias, Bolze, Tom, Liang, Qingqing, Köhler, Jens, Sarpe, Cristian, Baumert, Thomas

“…Shine a light: A circular dichroism effect in the ±10 % regime on randomly oriented chiral molecules in the gas phase is demonstrated. The signal is derived…”
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Unbiased RNA-Seq-driven identification and validation of reference genes for quantitative RT-PCR analyses of pooled cancer exosomes by Dai, Yao, Cao, Yumeng, Köhler, Jens, Lu, Aiping, Xu, Shaohua, Wang, Haiyun

“…Exosomes are extracellular vesicles (EVs) derived from endocytic compartments of eukaryotic cells which contain various biomolecules like mRNAs or miRNAs…”
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Thoracic staging in lung cancer: prospective comparison of 18F-FDG PET/MR imaging and 18F-FDG PET/CT by Heusch, Philipp, Buchbender, Christian, Köhler, Jens, Nensa, Felix, Gauler, Thomas, Gomez, Benedikt, Reis, Henning, Stamatis, Georgios, Kühl, Hilmar, Hartung, Verena, Heusner, Till A

“…Therapeutic decisions in non-small cell lung cancer (NSCLC) patients depend on the tumor stage. PET/CT with (18)F-FDG is widely accepted as the diagnostic…”
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