Search Results - "Kônig, Rainer"

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1 by Tönjes, Martje, Barbus, Sebastian, Park, Yoon Jung, Wang, Wei, Schlotter, Magdalena, Lindroth, Anders M, Pleier, Sabrina V, Bai, Alfa H C, Karra, Daniela, Piro, Rosario M, Felsberg, Jörg, Addington, Adele, Lemke, Dieter, Weibrecht, Irene, Hovestadt, Volker, Rolli, Claudio G, Campos, Benito, Turcan, Sevin, Sturm, Dominik, Witt, Hendrik, Chan, Timothy A, Herold-Mende, Christel, Kemkemer, Ralf, König, Rainer, Schmidt, Kathrin, Hull, William-Edmund, Pfister, Stefan M, Jugold, Manfred, Hutson, Susan M, Plass, Christoph, Okun, Jürgen G, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard

“…Branched-chain amino acid transaminase 1, the enzyme that initiates the catabolism of branched-chain amino acids, is involved in glioma pathogenesis, making it…”
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Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism by Sharma, Ashwini Kumar, Eils, Roland, König, Rainer

“…Somatic copy number alterations frequently occur in the cancer genome affecting not only oncogenic or tumor suppressive genes, but also passenger and potential…”
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Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models by Palsson, Bernhard Ø, Lewis, Nathan E, Hixson, Kim K, Conrad, Tom M, Lerman, Joshua A, Charusanti, Pep, Polpitiya, Ashoka D, Adkins, Joshua N, Schramm, Gunnar, Purvine, Samuel O, Lopez-Ferrer, Daniel, Weitz, Karl K, Eils, Roland, König, Rainer, Smith, Richard D

“…After hundreds of generations of adaptive evolution at exponential growth, Escherichia coli grows as predicted using flux balance analysis (FBA) on…”
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MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer by Ward, Aoife, Shukla, Kirti, Balwierz, Aleksandra, Soons, Zita, König, Rainer, Sahin, Özgür, Wiemann, Stefan

“…Tamoxifen is an endocrine therapy which is administered to up to 70% of all breast cancer patients with oestrogen receptor alpha (ERα) expression. Despite the…”
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Genetic analysis of sudden unexplained death: A multidisciplinary approach by Kauferstein, Silke, Kiehne, Nadine, Jenewein, Tina, Biel, Stephanie, Kopp, Marnie, König, Rainer, Erkapic, Damir, Rothschild, Markus, Neumann, Thomas

“…Abstract Each year infants, children and young adults die suddenly and unexpectedly. In many cases the cause of death can be elucidated by medico-legal…”
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Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma by Kolte, Amol, König, Rainer

“…The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained…”
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Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations by Reuss, David E., Piro, Rosario M., Jones, David T. W., Simon, Matthias, Ketter, Ralf, Kool, Marcel, Becker, Albert, Sahm, Felix, Pusch, Stefan, Meyer, Jochen, Hagenlocher, Christian, Schweizer, Leonille, Capper, David, Kickingereder, Phillipp, Mucha, Jana, Koelsche, Christian, Jäger, Natalie, Santarius, Thomas, Tarpey, Patrick S., Stephens, Philip J., Andrew Futreal, P., Wellenreuther, Ruth, Kraus, Jürgen, Lenartz, Doris, Herold-Mende, Christel, Hartmann, Christian, Mawrin, Christian, Giese, Nathalia, Eils, Roland, Collins, V. Peter, König, Rainer, Wiestler, Otmar D., Pfister, Stefan M., von Deimling, Andreas

“…Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of…”
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Evaluating the effects of automation components in service networks of rail freight by Pollehn, Tobias, Ruf, Moritz, König, Rainer

“…This paper addresses the assessment of the effects of automation components on the design of service networks in rail freight. We define three automation…”
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Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach by Poos, Alexandra M, Kordaß, Theresa, Kolte, Amol, Ast, Volker, Oswald, Marcus, Rippe, Karsten, König, Rainer

“…Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the…”
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Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein by Schweizer, Leonille, Koelsche, Christian, Sahm, Felix, Piro, Rosario M., Capper, David, Reuss, David E., Pusch, Stefan, Habel, Antje, Meyer, Jochen, Göck, Tanja, Jones, David T. W., Mawrin, Christian, Schittenhelm, Jens, Becker, Albert, Heim, Stephanie, Simon, Matthias, Herold-Mende, Christel, Mechtersheimer, Gunhild, Paulus, Werner, König, Rainer, Wiestler, Otmar D., Pfister, Stefan M., von Deimling, Andreas

“…Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity…”
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Estimating the activity of transcription factors by the effect on their target genes by Schacht, Theresa, Oswald, Marcus, Eils, Roland, Eichmüller, Stefan B, König, Rainer

“…Understanding regulation of transcription is central for elucidating cellular regulation. Several statistical and mechanistic models have come up the last…”
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Large-scale in silico modeling of metabolic interactions between cell types in the human brain by Palsson, Bernhard Ø, Lewis, Nathan E, Schramm, Gunnar, Bordbar, Aarash, Schellenberger, Jan, Andersen, Michael P, Cheng, Jeffrey K, Patel, Nilam, Yee, Alex, Lewis, Randall A, Eils, Roland, König, Rainer

“…The metabolism of tissues often involves interactions between several types of cell. Lewis et al . model metabolism within and between neurons in the human…”
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Cognate Interaction With CD4 + T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype by Eisel, David, Das, Krishna, Dickes, Elke, König, Rainer, Osen, Wolfram, Eichmüller, Stefan B

“…The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor…”
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Customized Oligonucleotide Microarray Gene Expression–Based Classification of Neuroblastoma Patients Outperforms Current Clinical Risk Stratification by OBERTHUER, André, BERTHOLD, Frank, SCHWAB, Manfred, BRORS, Benedikt, WESTERMANN, Frank, FISCHER, Matthias, WARNAT, Patrick, HERO, Barbara, KAHLERT, Yvonne, SPITZ, Rudiger, ERNESTUS, Karen, KONIG, Rainer, HAAS, Stefan, EILS, Roland

“…To develop a gene expression-based classifier for neuroblastoma patients that reliably predicts courses of the disease. Two hundred fifty-one neuroblastoma…”
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SplicingCompass: differential splicing detection using RNA-seq data by Aschoff, Moritz, Hotz-Wagenblatt, Agnes, Glatting, Karl-Heinz, Fischer, Matthias, Eils, Roland, König, Rainer

“…Alternative splicing is central for cellular processes and substantially increases transcriptome and proteome diversity. Aberrant splicing events often have…”
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Reprogramming of macrophages employing gene regulatory and metabolic network models by Hörhold, Franziska, Eisel, David, Oswald, Marcus, Kolte, Amol, Röll, Daniela, Osen, Wolfram, Eichmüller, Stefan B, König, Rainer

“…Upon exposure to different stimuli, resting macrophages undergo classical or alternative polarization into distinct phenotypes that can cause fatal dysfunction…”
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Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly by Aramillo Irizar, Peer, Schäuble, Sascha, Esser, Daniela, Groth, Marco, Frahm, Christiane, Priebe, Steffen, Baumgart, Mario, Hartmann, Nils, Marthandan, Shiva, Menzel, Uwe, Müller, Jule, Schmidt, Silvio, Ast, Volker, Caliebe, Amke, König, Rainer, Krawczak, Michael, Ristow, Michael, Schuster, Stefan, Cellerino, Alessandro, Diekmann, Stephan, Englert, Christoph, Hemmerich, Peter, Sühnel, Jürgen, Guthke, Reinhard, Witte, Otto W., Platzer, Matthias, Ruppin, Eytan, Kaleta, Christoph

“…Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old…”
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Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas by Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, Brors, Benedikt, Beissbarth, Tim, Vandesompele, Jo, Pattyn, Filip, Hero, Barbara, König, Rainer, Fischer, Matthias, Schwab, Manfred

“…Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype…”
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Global expression analysis of the brown alga Ectocarpus siliculosus (Phaeophyceae) reveals large-scale reprogramming of the transcriptome in response to abiotic stress by Dittami, Simon M, Scornet, Delphine, Petit, Jean-Louis, Ségurens, Béatrice, Da Silva, Corinne, Corre, Erwan, Dondrup, Michael, Glatting, Karl-Heinz, König, Rainer, Sterck, Lieven, Rouzé, Pierre, Van de Peer, Yves, Cock, J Mark, Boyen, Catherine, Tonon, Thierry

“…Brown algae (Phaeophyceae) are phylogenetically distant from red and green algae and an important component of the coastal ecosystem. They have developed…”
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Evaluation of reverse phase protein array (RPPA)-based pathway-activation profiling in 84 non-small cell lung cancer (NSCLC) cell lines as platform for cancer proteomics and biomarker discovery by Ummanni, Ramesh, Mannsperger, Heiko A., Sonntag, Johanna, Oswald, Marcus, Sharma, Ashwini K., König, Rainer, Korf, Ulrike

“…The reverse phase protein array (RPPA) approach was employed for a quantitative analysis of 71 cancer-relevant proteins and phosphoproteins in 84 non-small…”
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