Search Results - "Kärrman, Carina"

Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist by Nicholls, David J, Wiley, Katherine, Dainty, Ian, MacIntosh, Fraser, Phillips, Caroline, Gaw, Alasdair, Mårdh, Carina Kärrman

“…In normal physiologic responses to injury and infection, inflammatory cells enter tissue and sites of inflammation through a chemotactic process regulated by…”
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Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data by Ericsson, Therese, Fridén, Markus, Kärrman-Mårdh, Carina, Dainty, Ian, Grime, Ken

“…Purpose A scientifically robust prediction of human dose is important in determining whether to progress a candidate drug into clinical development. A…”
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Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil activation by Selldén, Tilia, Mårdh, Carina Kärrman, Joelsson, Martin, Vikgren, Jenny, Johnsson, Åse, Larsson, Gunilla, Glinatsi, Daniel, Stubendorff, Kajsa, Svensson, Karin, Gjertsson, Inger, Rudin, Anna, Lundell, Anna-Carin, Ekwall, Anna-Karin Hultgård

“…The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop interstitial lung…”
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Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases by Hemmerling, Martin, Nilsson, Stinabritt, Edman, Karl, Eirefelt, Stefan, Russell, Wayne, Hendrickx, Ramon, Johnsson, Eskil, Kärrman Mårdh, Carina, Berger, Markus, Rehwinkel, Hartmut, Abrahamsson, Anna, Dahmén, Jan, Eriksson, Anders R, Gabos, Balint, Henriksson, Krister, Hossain, Nafizal, Ivanova, Svetlana, Jansson, Anne-Helene, Jensen, Tina J, Jerre, Anders, Johansson, Henrik, Klingstedt, Tomas, Lepistö, Matti, Lindsjö, Martin, Mile, Irene, Nikitidis, Grigorios, Steele, John, Tehler, Ulrika, Wissler, Lisa, Hansson, Thomas

“…A class of potent, nonsteroidal, selective indazole ether-based glucocorticoid receptor modulators (SGRMs) was developed for the inhaled treatment of…”
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Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease by Thomas, Matthew, Malmgren, Anna, Stenvall, Kristina, Uddin, Mohib, Root, James, Mårdh, Carina Kärrman, Karabelas, Kostas

“…Neutrophils are important effector cells of antimicrobial immunity in an acute inflammatory response, with a primary role in the clearance of extracellular…”
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A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses by Gauvreau, Gail M, Boulet, Louis-Philippe, Leigh, Richard, Cockcroft, Donald W, Killian, Kieran J, Davis, Beth E, Deschesnes, Francine, Watson, Richard M, Swystun, Veronica, Mårdh, Carina Kärrman, Wessman, Peter, Jorup, Carin, Aurivillius, Magnus, O'Byrne, Paul M

“…Effective antiinflammatory therapies are needed for the treatment of asthma, but preferably without the systemic adverse effects of glucocorticosteroids. We…”
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Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications by Muthas, Daniel, Reznichenko, Anna, Balendran, Clare A., Böttcher, Gerhard, Clausen, Ib Groth, Kärrman Mårdh, Carina, Ottosson, Tomas, Uddin, Mohib, MacDonald, Thomas T., Danese, Silvio, Berner Hansen, Mark

“…Objectives: This review article describes the role of neutrophils in mucosal injury and the resulting crypt abscesses characteristic of ulcerative colitis. We…”
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Cloning, characterization and immunolocalization of human ameloblastin by MacDougall, Mary, Simmons, Darrin, Gu, Ting Ting, Forsman-Semb, Kristina, Kärrman Mårdh, Carina, Mesbah, Michael, Forest, Nadine, Krebsbach, Paul H., Yamada, Yoishi, Berdal, Ariane

“…Amelogenesis imperfecta is a broad classification of hereditary enamel defects, exhibiting both genetic and clinical diversity. Most amelogenesis imperfecta…”
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Ameloblastin Gene (AMBN) Maps within the Critical Region for Autosomal Dominant Amelogenesis Imperfecta at Chromosome 4q21 by MacDougall, Mary, DuPont, Barbara R., Simmons, Darrin, Reus, Bonnie, Krebsbach, Paul, Kärrman, Carina, Holmgren, Gösta, Leach, Robin J., Forsman, Kristina

“…Amelogenesis imperfecta (AI) is a broad group of hereditary enamel defects that is characterized by a high degree of clinical diversity. Recently, the local…”
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IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways by Manson, Martijn L., Säfholm, Jesper, James, Anna, Johnsson, Anna-Karin, Bergman, Per, Al-Ameri, Mamdoh, Orre, Ann-Charlotte, Kärrman-Mårdh, Carina, Dahlén, Sven-Erik, Adner, Mikael

“…Specific inflammatory pathways are indicated to contribute to severe asthma, but their individual involvement in the development of airway hyperresponsiveness…”
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Human ameloblastin gene: genomic organization and mutation analysis in amelogenesis imperfecta patients by Kärrman Mårdh, Carina, Bäckman, Birgitta, Simmons, Darrin, Golovleva, Irina, Gu, Ting Ting, Holmgren, Gösta, MacDougall, Mary, Forsman-Semb, Kristina

“…A gene encoding the enamel protein ameloblastin (AMBN) was recently localized to a region on chromosome 4q21 containing a gene for the inherited enamel defect…”
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Long-Acting β 2 -Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)-Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR by Rider, Christopher F, Altonsy, Mohammed O, Mostafa, Mahmoud M, Shah, Suharsh V, Sasse, Sarah, Manson, Martijn L, Yan, Dong, Kärrman-Mårdh, Carina, Miller-Larsson, Anna, Gerber, Anthony N, Giembycz, Mark A, Newton, Robert

“…In asthma, the clinical efficacy of inhaled corticosteroids (ICSs) is enhanced by long-acting -adrenoceptor agonists (LABAs). ICSs, or more accurately,…”
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Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis by Malla, Sudarshan R, Kärrman Mårdh, Carina, Günther, Annett, Mahajan, Ujjwal M, Sendler, Matthias, D'Haese, Jan, Weiss, Frank Ulrich, Lerch, Markus M, Hansen, Mark Berner, Mayerle, Julia

“…Abstract Introduction Acute pancreatitis is a common gastrointestinal disorder burdened with a high mortality. Two pathophysiological events during…”
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Mapping of the Locus for Autosomal Dominant Amelogenesis Imperfecta (AIH2) to a 4-Mb YAC Contig on Chromosome 4q11–q21 by Kärrman, Carina, Bäckman, Birgitta, Dixon, Michael, Holmgren, Gösta, Forsman, Kristina

“…Amelogenesis imperfecta (AI) is a clinically and genetically heterogeneous group of inherited enamel defects. We recently mapped a locus for autosomal dominant…”
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Genetic heterogeneity of autosomal dominant amelogenesis imperfecta demonstrated by its exclusion from the AIH2 region on human chromosome 4Q by Kärrman, Carina, Bäckman, Birgitta, Holmgren, Gösta, Forsman, Kristina

“…Amelogenesis imperfecta (AI) is a group of hereditary enamel defects, characterized by large clinical diversity. On the basis of differences in clinical…”
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