Search Results - "Kähkönen, Tiina E"

Insights into immuno-oncology drug development landscape with focus on bone metastasis by Kähkönen, Tiina E, Halleen, Jussi M, MacRitchie, Gary, Andersson, Ronnie M, Bernoulli, Jenni

“…Bone is among the main sites of metastasis in breast, prostate and other major cancers. Bone metastases remain incurable causing high mortality, severe…”
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Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis by Kähkönen, Tiina E, Halleen, Jussi M, Bernoulli, Jenni

“…Immunotherapies provide a potential treatment option for currently incurable bone metastases. Bone marrow is an important secondary lymphoid organ with a…”
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Immunotherapies and Metastatic Cancers: Understanding Utility and Predictivity of Human Immune Cell Engrafted Mice in Preclinical Drug Development by Kähkönen, Tiina E., Halleen, Jussi M., Bernoulli, Jenni

“…Metastases cause high mortality in several cancers and immunotherapies are expected to be effective in the prevention and treatment of metastatic disease…”
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Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Bernoulli, Jenni, Tanaka, Azusa, Halleen, Jussi M., Mäki-Jouppila, Jenni H. E., Suominen, Mari I., Kähkönen, Tiina E., Seiler, Michael

“…Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed…”
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Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth by Tarkkonen, Kati M, Nilsson, Emeli M, Kähkönen, Tiina E, Dey, Julien H, Heikkilä, Jari E, Tuomela, Johanna M, Liu, Qing, Hynes, Nancy E, Härkönen, Pirkko L

“…Fibroblast growth factors (FGFs) regulate the growth and progression of breast cancer. FGF signaling is transduced through FGF receptors 1-4, which have…”
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Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model by Kähkönen, Tiina E., Tuomela, Johanna M., Grönroos, Tove J., Halleen, Jussi M., Ivaska, Kaisa K., Härkönen, Pirkko L.

“…Advanced breast cancer has a high incidence of bone metastases. In bone, breast cancer cells induce osteolytic or mixed bone lesions by inducing an imbalance…”
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Novel and Conventional Preclinical Models to Investigate Bone Metastasis by Kähkönen, Tiina E., Bernoulli, Jenni, Halleen, Jussi M., Suominen, Mari I.

“…Purpose of Review The purpose of this review is to emphasize the use of bone metastasis models in preclinical research. As classical models have been…”
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Abstract 2870: Limited data from clinical trials assessing immunotherapy effects on bone metastases by Kähkönen, Tiina E., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Bone metastases are a significant cause of mortality in many major cancers. They are difficult to treat and their response rate to standard-of-care…”
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Abstract 4850: The relevance of using proper preclinical models when developing therapeutics for localized or bone metastatic prostate cancer by Kähkönen, Tiina E., Mäki-Jouppila, Jenni H.E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Early stages of prostate cancer are sensitive to androgen deprivation therapy, but upon progression the disease develops to metastatic…”
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Abstract 4588: Characterization of anti-CTLA-4 effects on tumor growth and immune microenvironment in a syngeneic CT26.WT colon carcinoma mouse model by Mäki-Jouppila, Jenni H., Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Colorectal cancer is the third most common type of cancer and one of the leading causes of cancer related deaths. It is a group of various diseases at…”
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Abstract 1634: Orthotopic and bone metastasis prostate cancer models using the 22Rv1 cell line by Zdrojewska, Justyna, Kähkönen, Tiina E., Mäki-Jouppila, Jenni H., Valkonen, Masi, Ruusuvuori, Pekka, Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Prostate cancer is the most common cancer in men. Upon diagnosed malignancy the growth of the tumors is androgen driven in a majority of the cases…”
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Abstract 5740: Identification of genetic signatures in bone metastasis of breast and prostate cancer by Kähkönen, Tiina E., Halleen, Jussi M., Bernoulli, Jenni

“…Abstract Bone metastases (BM) cause high mortality and are present in 70-90% of advanced breast and prostate cancer patients. Cancer is a complex genetic…”
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Abstract 709: Anti-PD-1 therapy reduces bone lesion growth in a novel syngeneic bladder cancer bone metastasis model by Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni, Scholz, Arne

“…Abstract Bladder cancer is a common and aggressive type of cancer occurring both in women and in men. At diagnosis, lymph node involvement is frequently…”
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Abstract 1162: Castration-resistant prostate cancer bone metastasis model to assess new therapeutics by Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Bernoulli, Jenni, Lejeune, Pascale

“…Abstract The role of androgens in the regulation of growth of primary prostate cancer is well established but less recognized in the context of advanced bone…”
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Abstract 4614: Establishment of a HER2 positive breast cancer bone metastasis model for validation of novel therapies by Kähkönen, Tiina E., Suominen, Mari I., Mäki-Jouppila, Jenni H., Halleen, Jussi M., Bernoulli, Jenni, Grant, Derek

“…Abstract Breast cancers with overexpression of human epidermal growth factor receptor 2 (HER2+) have aggressive clinical behavior, and at advanced stages are…”
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Abstract 2814: Systemic and local bone metastasis models for immuno-oncology drug development by Kähkönen, Tiina E., Suominen, Mari I., Mäki-Jouppila, Jenni H., Halleen, Jussi M., Scholz, Arne, Bernoulli, Jenni

“…Abstract Bone metastases are common and count 30-70% of metastases in breast, lung, and bladder cancer, and 80% of multiple myeloma patients have bone disease…”
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Abstract B144: Lack of immunotherapy efficacy in a syngeneic bone metastasis model of triple-negative breast cancer by Kähkönen, Tiina E, Suominen, Mari I, Mäki-Jouppila, Jenni HE, Halleen, Jussi M, Bernoulli, Jenni

“…Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive cancer with treatment options limited to standard-of-care chemotherapy. TNBC…”
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Abstract 2815: Immunotherapy development landscape for bone metastasis - need of predictive preclinical efficacy evaluation for de-risking clinical development by Kähkönen, Tiina E., Halleen, Jussi M., MacRitchie, Gary, Andersson, Ronnie M., Bernoulli, Jenni

“…Abstract Most cancer deaths are due to metastases, and bone metastases are challenge especially in breast and prostate cancer, being developed in 70-90% of…”
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Abstract 1738: PD-1/PD-L1 expression and tumor-infiltrating immune cells in triple-negative breast cancer: Characterization of preclinical primary tumor and bone metastasis models in humanized mice by Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Tanaka, Azusa, Seiler, Michael, Haapaniemi, Teppo, Bernoulli, Jenni

“…Abstract Expression of programmed cell death-1 receptor (PD-1), programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in triple-negative…”
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Abstract 1677: Differential efficacy of PD-1 targeted immunomodulation in preclinical models of primary and bone metastatic triple-negative breast cancer by Kähkönen, Tiina E., Suominen, Mari I., Halleen, Jussi M., Haapaniemi, Teppo, Tanaka, Azusa, Seiler, Michael, Bernoulli, Jenni

“…Abstract Immuno-oncology (IO) has provided groundbreaking results in cancer treatment. Triple-negative breast cancer (TNBC) tumors attract immune cells, and…”
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