Search Results - "KÜHNE, Martin"

DNA Double-Strand Break Repair of Blood Lymphocytes and Normal Tissues Analysed in a Preclinical Mouse Model: Implications for Radiosensitivity Testing by RÜBE, Claudia E, GRUDZENSKI, Saskia, KUHNE, Martin, XIAORONG DONG, RIEF, Nicole, LOBRICH, Markus, RÜBE, Christian

“…Purpose: Radiotherapy is an effective cancer treatment, but a few patients suffer severe radiation toxicities in neighboring normal tissues. There is…”
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A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity by KÜHNE, Martin, RIBALLO, Enriqueta, RIEF, Nicole, ROTHKAMM, Kai, JEGGO, Penny A, LÖBRICH, Markus

“…The ATM protein, which is mutated in individuals with ataxia telangiectasia (AT), is central to cell cycle checkpoint responses initiated by DNA double-strand…”
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Accumulation of DNA Double-Strand Breaks in Normal Tissues After Fractionated Irradiation by Rübe, Claudia E., M.D., Ph.D, Fricke, Andreas, Ph.D, Wendorf, Juliane, Stützel, Annika, Kühne, Martin, Ph.D, Ong, Mei Fang, Ph.D, Lipp, Peter, Ph.D, Rübe, Christian, M.D., Ph.D

“…Purpose There is increasing evidence that genetic factors regulating the recognition and/or repair of DNA double-strand breaks (DSBs) are responsible for…”
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DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities by Rübe, Claudia E., M.D., Ph.D, Fricke, Andreas, Ph.D, Schneider, Ruth, M.D, Simon, Karin, M.D, Kühne, Martin, Ph.D, Fleckenstein, Jochen, M.D, Gräber, Stefan, Ph.D, Graf, Norbert, M.D., Ph.D, Rübe, Christian, M.D., Ph.D

“…Purpose To evaluate, in a pilot study, the phosphorylated H2AX (γH2AX) foci approach for identifying patients with double-strand break (DSB) repair…”
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The Impact of Individual In Vivo Repair of DNA Double-Strand Breaks on Oral Mucositis in Adjuvant Radiotherapy of Head-and-Neck Cancer by Fleckenstein, Jochen, M.D, Kühne, Martin, Ph.D, Seegmüller, Katharina, M.D, Derschang, Sarah, M.D, Melchior, Patrick, M.D, Gräber, Stefan, M.D., Ph.D, Fricke, Andreas, Ph.D, Rübe, Claudia E., M.D., Ph.D, Rübe, Christian, M.D., Ph.D

“…Purpose To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with…”
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DNA Double-Strand Break Rejoining in Complex Normal Tissues by Rübe, Claudia E., M.D., Ph.D, Dong, Xiaorong, M.D, Kühne, Martin, Ph.D, Fricke, Andreas, Ph.D, Kaestner, Lars, Ph.D, Lipp, Peter, Ph.D, Rübe, Christian, M.D., Ph.D

“…Purpose The clinical radiation responses of different organs vary widely and likely depend on the intrinsic radiosensitivities of their different cell…”
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X-irradiation of cells on glass slides has a dose doubling impact by Kegel, Peter, Riballo, Enriqueta, Kühne, Martin, Jeggo, Penny A., Löbrich, Markus

“…Immunofluorescence detection of γH2AX foci is a widely used tool to quantify the induction and repair of DNA double-strand breaks (DSBs) induced by ionising…”
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In vivo Formation and Repair of DNA Double-Strand Breaks after Computed Tomography Examinations by Löbrich, Markus, Rief, Nicole, Kühne, Martin, Heckmann, Martina, Fleckenstein, Jochen, Rübe, Christian, Uder, Michael, Setlow, Richard B.

“…Ionizing radiation can lead to a variety of deleterious effects in humans, most importantly to the induction of cancer. DNA double-strand breaks (DSBs) are…”
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Erratum: Improving the Traditional Information Management in Natural Sciences [Data Science Journal, Volume 8, 10 January 2009, 18-26] by Kühne, Martin, Liehr, Andreas W.

“…The following PDF indicates errata for the original article entitled "Improving the Traditional Information Management in Natural Sciences" by Martin Kühne and…”
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Improving the Traditional Information Management in Natural Sciences by Kühne, Martin, Liehr, Andreas W.

“…It is common practice that in teams working in the field of natural sciences all group members manage their primary data in highly individual systems. The…”
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Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks by ROTHKAMM, Kai, KÜHNE, Martin, JEGGO, Penny A, LÖBRICH, Markus

“…Two major pathways for repairing DNA double-strand breaks (DSBs) have been identified in mammalian cells, nonhomologous end-joining (NHEJ) and homologous…”
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A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci by Riballo, Enriqueta, Kühne, Martin, Rief, Nicole, Doherty, Aidan, Smith, Graeme C.M., Recio, Marı́a-José, Reis, Caroline, Dahm, Kirsten, Fricke, Andreas, Krempler, Andrea, Parker, Antony R., Jackson, Stephen P., Gennery, Andrew, Jeggo, Penny A., Löbrich, Markus

“…The hereditary disorder ataxia telangiectasia (A-T) is associated with striking cellular radiosensitivity that cannot be attributed to the characterized cell…”
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Nonlinear rheological properties and stability of dibenzylidene sorbitol fiber networks in poly(propylene oxide) by Kühne, Martin, Friedrich, Christian

“…Dibenzylidene sorbitol (DBS) is known to gel organic liquids and polymers such as poly(propylene oxide) (PPO) by forming long fibers and fiber networks…”
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Thermo-thickening during melting of dibenzylidene sorbitol fibre networks by Kühne, Martin, Wurth, Jonathan, Friedrich, Christian

“…Gels of dibenzylidene sorbitol (DBS) in poly(propylene oxide) (PPO) show an increase in viscosity in a certain temperature range during melting. This so-called…”
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On the communication of scientific data: The Full-Metadata Format by Riede, Moritz, Schueppel, Rico, Sylvester-Hvid, Kristian O., Kühne, Martin, Röttger, Michael C., Zimmermann, Klaus, Liehr, Andreas W.

“…In this paper, we introduce a scientific format for text-based data files, which facilitates storing and communicating tabular data sets. The so-called…”
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DNA Double-Strand Break Misrejoining after Exposure of Primary Human Fibroblasts to C K Characteristic X Rays, 29 kVp X Rays and 60 Co γ Rays by Kühne, Martin, Urban, Gerhard, Frankenberg, Dieter, Löbrich, Markus

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DNA Double-Strand Break Misrejoining after Exposure of Primary Human Fibroblasts to ${\rm C}_{{\rm K}}$ Characteristic X Rays, 29 kVp X Rays and 60 Co γ Rays by Kühne, Martin, Urban, Gerhard, Frankenberg, Dieter, Löbrich, Markus

“…The efficiency of ionizing photon radiation for inducing mutations, chromosome aberrations, neoplastic cell transformation, and cell killing depends on the…”
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DNA Double-Strand Break Misrejoining after Exposure of Primary Human Fibroblasts to CK Characteristic X Rays, 29 kVp X Rays and 60Co γ Rays by Kühne, Martin, Urban, Gerhard, Frankenberg, Dieter, Löbrich, Markus

“…Kühne, M., Urban, G., Frankenberg, D. and Löbrich, M. DNA Double-Strand Break Misrejoining after Exposure of Primary Human Fibroblasts to CK Characteristic X…”
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Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts by Löbrich, Markus, Kühne, Martin, Wetzel, Jana, Rothkamm, Kai

“…Chromosomal aberrations are believed to result from the incorrect joining of DNA double‐strand breaks (DSBs). In an attempt to investigate induction and…”
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Comments on the Paper “No Detectable Misrejoining in Double-Minute Chromosomes” by Nevaldine et al. (Radiat. Res. 152, 154–159, 1999) by Löbrich, Markus, Kühne, Martin, Rothkamm, Kai, Rydberg, Björn, Cooper, Priscilla K.

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