Search Results - "KÜBLER, Kirsten"

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues by Yizhak, Keren, Aguet, François, Kim, Jaegil, Hess, Julian M, Kübler, Kirsten, Grimsby, Jonna, Frazer, Ruslana, Zhang, Hailei, Haradhvala, Nicholas J, Rosebrock, Daniel, Livitz, Dimitri, Li, Xiao, Arich-Landkof, Eila, Shoresh, Noam, Stewart, Chip, Segrè, Ayellet V, Branton, Philip A, Polak, Paz, Ardlie, Kristin G, Getz, Gad

“…How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 normal…”
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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer by Polak, Paz, Kim, Jaegil, Braunstein, Lior Z, Karlic, Rosa, Haradhavala, Nicholas J, Tiao, Grace, Rosebrock, Daniel, Livitz, Dimitri, Kübler, Kirsten, Mouw, Kent W, Kamburov, Atanas, Maruvka, Yosef E, Leshchiner, Ignaty, Lander, Eric S, Golub, Todd R, Zick, Aviad, Orthwein, Alexandre, Lawrence, Michael S, Batra, Rajbir N, Caldas, Carlos, Haber, Daniel A, Laird, Peter W, Shen, Hui, Ellisen, Leif W, D'Andrea, Alan D, Chanock, Stephen J, Foulkes, William D, Getz, Gad

“…Paz Polak, Jaegil Kim, Lior Z. Braunstein and colleagues have identified patterns of genome-wide mutation in certain breast cancers that can be used to…”
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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA by Herzner, Anna-Maria, Hagmann, Cristina Amparo, Goldeck, Marion, Wolter, Steven, Kübler, Kirsten, Wittmann, Sabine, Gramberg, Thomas, Andreeva, Liudmila, Hopfner, Karl-Peter, Mertens, Christina, Zillinger, Thomas, Jin, Tengchuan, Xiao, Tsan Sam, Bartok, Eva, Coch, Christoph, Ackermann, Damian, Hornung, Veit, Ludwig, Janos, Barchet, Winfried, Hartmann, Gunther, Schlee, Martin

“…Truncated reverse transcription of HIV RNA produces a single-stranded DNA intermediate with a unique Y-DNA stem-loop structure flanked by unpaired guanines…”
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Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma by Gopal, Raj K., Kübler, Kirsten, Calvo, Sarah E., Polak, Paz, Livitz, Dimitri, Rosebrock, Daniel, Sadow, Peter M., Campbell, Braidie, Donovan, Samuel E., Amin, Salma, Gigliotti, Benjamin J., Grabarek, Zenon, Hess, Julian M., Stewart, Chip, Braunstein, Lior Z., Arndt, Peter F., Mordecai, Scott, Shih, Angela R., Chaves, Frances, Zhan, Tiannan, Lubitz, Carrie C., Kim, Jiwoong, Iafrate, A. John, Wirth, Lori, Parangi, Sareh, Leshchiner, Ignaty, Daniels, Gilbert H., Mootha, Vamsi K., Dias-Santagata, Dora, Getz, Gad, McFadden, David G.

“…Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to radioiodine therapy that exhibits an accumulation of mitochondria. We…”
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N6-methyladenosine RNA modification (m6A) is of prognostic value in HPV-dependent vulvar squamous cell carcinoma by Condic, Mateja, Thiesler, Thore, Staerk, Christian, Klümper, Niklas, Ellinger, Jörg, Egger, Eva K, Kübler, Kirsten, Kristiansen, Glen, Mustea, Alexander, Ralser, Damian J

“…Abstract Background Vulvar squamous cell carcinoma (VSCC) is an uncommon gynecologic malignancy but with an increasing incidence in recent years…”
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Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma by Kübler, Kirsten, Ayub, Tiyasha H, Weber, Sarah K, Zivanovic, Oliver, Abramian, Alina, Keyver-Paik, Mignon-Denise, Mallmann, Michael R, Kaiser, Christina, Serçe, Nuran Bektas, Kuhn, Walther, Rudlowski, Christian

“…Abstract Objective Endometrial adenocarcinoma is one of the most common gynecologic malignancies worldwide and in stages confined to the uterus considered to…”
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Accumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer by Ayub, Tiyasha H, Keyver-Paik, Mignon-Denise, Debald, Manuel, Rostamzadeh, Babak, Thiesler, Thore, Schröder, Lars, Barchet, Winfried, Abramian, Alina, Kaiser, Christina, Kristiansen, Glen, Kuhn, Walther, Kübler, Kirsten

“…Although ovarian cancer is a highly chemosensitive disease, it is only infrequently cured. One of the major reasons lies in the presence of drug-resistant…”
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Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells by Kübler, Kirsten, tho Pesch, Carola, Gehrke, Nadine, Riemann, Soheila, Daßler, Juliane, Coch, Christoph, Landsberg, Jennifer, Wimmenauer, Vera, Pölcher, Martin, Rudlowski, Christian, Tüting, Thomas, Kuhn, Walther, Hartmann, Gunther, Barchet, Winfried

“…Owing to high rates of tumor relapse, ovarian cancer remains a fatal disease for which new therapeutic approaches are urgently needed. Accumulating evidence…”
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Targeted Activation of RNA Helicase Retinoic Acid-Inducible Gene-I Induces Proimmunogenic Apoptosis of Human Ovarian Cancer Cells by KÜBLER, Kirsten, GEHRKE, Nadine, BARCHET, Winfried, RIEMANN, Soheila, BÖHNERT, Volker, ZILLINGER, Thomas, HARTMANN, Evelyn, PÖLCHER, Martin, RUDLOWSKI, Christian, KUHN, Walther, HARTMANN, Gunther

“…Most malignant cells are poorly immunogenic and fail to elicit an effective antitumor immune response. In contrast, viral infections of cells are promptly…”
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COOBoostR: An Extreme Gradient Boosting-Based Tool for Robust Tissue or Cell-of-Origin Prediction of Tumors by Yang, Sungmin, Ha, Kyungsik, Song, Woojeung, Fujita, Masashi, Kübler, Kirsten, Polak, Paz, Hiyama, Eiso, Nakagawa, Hidewaki, Kim, Hong-Gee, Lee, Hwajin

“…We present here COOBoostR, a computational method designed for the putative prediction of the tissue- or cell-of-origin of various cancer types. COOBoostR…”
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Cardiorenal syndrome is present in human fetuses with severe, isolated urinary tract malformations by Merz, Waltraut M, Kübler, Kirsten, Fimmers, Rolf, Willruth, Arne, Stoffel-Wagner, Birgit, Gembruch, Ulrich

“…We analyzed the association between renal and cardiovascular parameters in fetuses with isolated severe urinary tract malformations. 39 fetuses at a mean…”
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Diverse mutational landscapes in human lymphocytes by Machado, Heather E., Mitchell, Emily, Øbro, Nina F., Kübler, Kirsten, Davies, Megan, Leongamornlert, Daniel, Cull, Alyssa, Maura, Francesco, Sanders, Mathijs A., Cagan, Alex T. J., McDonald, Craig, Belmonte, Miriam, Shepherd, Mairi S., Vieira Braga, Felipe A., Osborne, Robert J., Mahbubani, Krishnaa, Martincorena, Iñigo, Laurenti, Elisa, Green, Anthony R., Getz, Gad, Polak, Paz, Saeb-Parsy, Kourosh, Hodson, Daniel J., Kent, David G., Campbell, Peter J.

“…The lymphocyte genome is prone to many threats, including programmed mutation during differentiation 1 , antigen-driven proliferation and residency in diverse…”
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In vivo intratumor angiogenic treatment effects during taxane-based neoadjuvant chemotherapy of ovarian cancer by Pölcher, Martin, Rudlowski, Christian, Friedrichs, Nicolaus, Mielich, Marieke, Höller, Tobias, Wolfgarten, Mathias, Kübler, Kirsten, Büttner, Reinhard, Kuhn, Walther, Braun, Michael

“…The aim of our study was to analyze the effect of taxane-based chemotherapy on tumor angiogenesis in patients with advanced epithelial ovarian cancer. Within a…”
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Genome Sequencing to Discover Drivers of Clonal Expansion in Smoldering Multiple Myeloma by Alberge, Jean-Baptiste, Dutta, Ankit K., Lightbody, Elizabeth D., Poletti, Andrea, Wallin, Sofia, Dunford, Andrew, Coorens, Tim, Loinaz, Xavi, Boehner, Cody J., Su, Nang Kham, Hevenor, Laura, Towle, Katherine, Perry, Jacqueline, Kübler, Kirsten, Sklavenitis-Pistofidis, Romanos, Hess, Julian, Stewart, Chip, Getz, Gad, Ghobrial, Irene M.

“…Background Better prediction models are required to identify patients with high-risk smoldering multiple myeloma (SMM) who can benefit from early intervention…”
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AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication by Monjé, Nanna, Dragomir, Mihnea P., Sinn, Bruno V., Hoffmann, Inga, Makhmut, Anuar, Simon, Tincy, Kunze, Catarina A., Ihlow, Jana, Schmitt, Wolfgang D., Pohl, Jonathan, Piwonski, Iris, Marchenko, Sofya, Keunecke, Carlotta, Calina, Teodor G., Tiso, Francesca, Kulbe, Hagen, Kreuzinger, Caroline, Cacsire Castillo-Tong, Dan, Sehouli, Jalid, Braicu, Elena I., Denkert, Carsten, Darb-Esfahani, Silvia, Kübler, Kirsten, Capper, David, Coscia, Fabian, Morkel, Markus, Horst, David, Sers, Christine, Taube, Eliane T.

“…Background The aim of this study was to analyse transcriptomic differences between primary and recurrent high-grade serous ovarian carcinoma (HGSOC) to…”
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Genetic alterations of HLA‐class II in ovarian cancer by Kübler, Kirsten, Arndt, Peter F., Wardelmann, Eva, Landwehr, Christina, Krebs, Dieter, Kuhn, Walther, van der Ven, Katrin

“…The immune system controls tumor formation through identification and elimination of cellular alterations. Consequently, cancer development in immune competent…”
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Tumoral PD-L1 expression defines a subgroup of poor-prognosis vulvar carcinomas with non-viral etiology by Hecking, Thomas, Thiesler, Thore, Schiller, Cynthia, Lunkenheimer, Jean-Marc, Ayub, Tiyasha H, Rohr, Andrea, Condic, Mateja, Keyver-Paik, Mignon-Denise, Fimmers, Rolf, Kirfel, Jutta, Kuhn, Walther, Kristiansen, Glen, Kübler, Kirsten

“…Vulvar cancer is rare but incidence rates are increasing due to an aging population and higher frequencies of young women being affected. In locally advanced,…”
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Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer by Pölcher, Martin, Eckhardt, Meike, Coch, Christoph, Wolfgarten, Matthias, Kübler, Kirsten, Hartmann, Gunther, Kuhn, Walther, Rudlowski, Christian

“…Purpose Sorafenib is a novel oral anticancer agent targeting signal transduction and angiogenic pathways through inhibitory effects against MAP kinases and…”
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Immune profiling of vulvar squamous cell cancer discovers a macrophage-rich subtype associated with poor prognosis by Condic, Mateja, Rohr, Andrea, Riemann, Soheila, Staerk, Christian, Ayub, Tiyasha H, Doeser, Anna, Zillinger, Thomas, Merkelbach-Bruse, Sabine, Buettner, Reinhard, Barchet, Winfried, Rudlowski, Christian, Mustea, Alexander, Kübler, Kirsten

“…The incidence rates of vulvar squamous cell cancer (VSCC) have increased over the past decades, requiring personalized oncologic approaches. Currently, lymph…”
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Individual management of cervical cancer in pregnancy by Hecking, Thomas, Abramian, Alina, Domröse, Christian, Engeln, Tabea, Thiesler, Thore, Leutner, Claudia, Gembruch, Ulrich, Keyver-Paik, Mignon-Denise, Kuhn, Walther, Kübler, Kirsten

“…Purpose The management of cervical cancer in pregnancy persists to be challenging. Therefore, identification of factors that influence the choice of…”
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