Search Results - "Jutz, Sabrina"

Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling by De Sousa Linhares, Annika, Battin, Claire, Jutz, Sabrina, Leitner, Judith, Hafner, Christine, Tobias, Joshua, Wiedermann, Ursula, Kundi, Michael, Zlabinger, Gerhard J., Grabmeier-Pfistershammer, Katharina, Steinberger, Peter

“…Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic…”
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Hand hygiene--evaluation of three disinfectant hand sanitizers in a community setting by Babeluk, Rita, Jutz, Sabrina, Mertlitz, Sarah, Matiasek, Johannes, Klaus, Christoph

“…Hand hygiene is acknowledged as the single most important measure to prevent nosocomial infections in the healthcare setting. Similarly, in non-clinical…”
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Reef invertebrate viromics: diversity, host specificity and functional capacity by Laffy, Patrick W., Wood‐Charlson, Elisha M., Turaev, Dmitrij, Jutz, Sabrina, Pascelli, Cecilia, Botté, Emmanuelle S., Bell, Sara C., Peirce, Tyler E., Weynberg, Karen D., van Oppen, Madeleine J. H., Rattei, Thomas, Webster, Nicole S.

“…Summary Recent metagenomic analyses have revealed a high diversity of viruses in the pelagic ocean and uncovered clear habitat‐specific viral distribution…”
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The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4 + T cells resembling iTreg by Tauber, Peter A, Kratzer, Bernhard, Schatzlmaier, Philipp, Smole, Ursula, Köhler, Cordula, Rausch, Lisa, Kranich, Jan, Trapin, Doris, Neunkirchner, Alina, Zabel, Maja, Jutz, Sabrina, Steinberger, Peter, Gadermaier, Gabriele, Brocker, Thomas, Stockinger, Hannes, Derdak, Sophia, Pickl, Winfried F

“…Treg cells have been shown to be an important part of immune-homeostasis and IL-2 which is produced upon T cell receptor (TCR)-dependent activation of T…”
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Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1 by Jutz, Sabrina, Leitner, Judith, Schmetterer, Klaus, Doel-Perez, Iago, Majdic, Otto, Grabmeier-Pfistershammer, Katharina, Paster, Wolfgang, Huppa, Johannes B., Steinberger, Peter

“…Engagement of the T cell receptor complex reprograms T cells for proliferation, cytokine production and differentiation towards effector cells. This process…”
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Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform by Rydzek, Julian, Nerreter, Thomas, Peng, Haiyong, Jutz, Sabrina, Leitner, Judith, Steinberger, Peter, Einsele, Hermann, Rader, Christoph, Hudecek, Michael

“…Chimeric antigen receptor (CAR)-T cell immunotherapy is under intense preclinical and clinical investigation, and it involves a rapidly increasing portfolio of…”
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Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery by Colomar-Carando, Natalia, Meseguer, Alberto, Company-Garrido, Iván, Jutz, Sabrina, Herrera-Fernández, Víctor, Olvera, Alex, Kiefer, Kerstin, Brander, Christian, Steinberger, Peter, Vicente, Rubén

“…Zinc deficiency causes immune dysfunction. In T lymphocytes, hypozincemia promotes thymus atrophy, polarization imbalance, and altered cytokine production…”
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TIM‐3 and CEACAM1 do not interact in cis and in trans by De Sousa Linhares, Annika, Kellner, Florian, Jutz, Sabrina, Zlabinger, Gerhard J., Gabius, Hans‐Joachim, Huppa, Johannes B., Leitner, Judith, Steinberger, Peter

“…TIM‐3 has been considered as a target in cancer immunotherapy. In T cells, inhibitory as well as activating functions have been ascribed to this molecule. Its…”
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A cellular platform for the evaluation of immune checkpoint molecules by Jutz, Sabrina, Hennig, Annika, Paster, Wolfgang, Asrak, Ömer, Dijanovic, Dejana, Kellner, Florian, Pickl, Winfried F, Huppa, Johannes B, Leitner, Judith, Steinberger, Peter

“…Blockade of the T cell coinhibitory molecules CTLA-4 and PD-1 has clinical utility to strengthen T cell responses. In addition to these immune checkpoints an…”
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Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens by Rosskopf, Sandra, Jutz, Sabrina, Neunkirchner, Alina, Candia, Martín R., Jahn-Schmid, Beatrice, Bohle, Barbara, Pickl, Winfried F., Steinberger, Peter

“…We have generated engineered APC to present immunodominant peptides derived from the major aero-allergens of birch and mugwort pollen, Bet v 1 142–153 and Art…”
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Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation by Schmidt, Ralf L. J., Jutz, Sabrina, Goldhahn, Katrin, Witzeneder, Nadine, Gerner, Marlene C., Trapin, Doris, Greiner, Georg, Hoermann, Gregor, Steiner, Guenter, Pickl, Winfried F., Burgmann, Heinz, Steinberger, Peter, Ratzinger, Franz, Schmetterer, Klaus G.

“…Chloroquine (CQ) is widely used as an anti-inflammatory therapeutic for rheumatic diseases. Although its modes of action on the innate immune system are well…”
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The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c‐Myc activation by Prodinger, Johanna, Loacker, Lisa J., Schmidt, Ralf L. J., Ratzinger, Franz, Greiner, Georg, Witzeneder, Nadine, Hoermann, Gregor, Jutz, Sabrina, Pickl, Winfried F., Steinberger, Peter, Marculescu, Rodrig, Schmetterer, Klaus G.

“…Functional and molecular effects of tryptophan metabolite PA on CD4+ T cell activation. Tryptophan metabolites, including kynurenine, 3‐hydroxyanthranilic…”
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Bidirectional polarization of T cell function via CD43 (IRC8P.437) by Modak, Madhura, Majdic, Otto, Cejka, Petra, Waidhofer-Söllner, Petra, Jutz, Sabrina, Steinberger, Peter, Zlabinger, Gerhard, Stoeckl, Johannes

“…Abstract Co-receptors, being either co-stimulatory or co-inhibitory, play a pivotal role in T cell immunity, as they decide the fate of T cell function. CD43…”
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Engagement of distinct epitopes on CD43 induces different co‐stimulatory pathways in human T cells by Modak, Madhura, Majdic, Otto, Cejka, Petra, Jutz, Sabrina, Puck, Alexander, Gerwien, Jens G., Steinberger, Peter, Zlabinger, Gerhard J., Strobl, Herbert, Stöckl, Johannes

“…Summary Co‐receptors, being either co‐stimulatory or co‐inhibitory, play a pivotal role in T‐cell immunity. Several studies have indicated that CD43, one of…”
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A T‐cell reporter platform for high‐throughput and reliable investigation of TCR function and biology by Müller, Thomas R, Schuler, Corinna, Hammel, Monika, Köhler, Amelie, Jutz, Sabrina, Leitner, Judith, Schober, Kilian, Busch, Dirk H, Steinberger, Peter

“…Objective Transgenic re‐expression enables unbiased investigation of T‐cell receptor (TCR)‐intrinsic characteristics detached from its original cellular…”
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Engagement of distinct epitopes on CD 43 induces different co‐stimulatory pathways in human T cells by Modak, Madhura, Majdic, Otto, Cejka, Petra, Jutz, Sabrina, Puck, Alexander, Gerwien, Jens G., Steinberger, Peter, Zlabinger, Gerhard J., Strobl, Herbert, Stöckl, Johannes

“…Summary Co‐receptors, being either co‐stimulatory or co‐inhibitory, play a pivotal role in T‐cell immunity. Several studies have indicated that CD 43, one of…”
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Iron Deprivation in Human T Cells Induces Nonproliferating Accessory Helper Cells by Berg, Verena, Modak, Madhura, Brell, Jennifer, Puck, Alexander, Künig, Sarojinidevi, Jutz, Sabrina, Steinberger, Peter, Zlabinger, Gerhard J, Stöckl, Johannes

“…Iron uptake via the transferrin receptor (CD71) is a pivotal mechanism for T cell proliferation. Yet, it is incompletely understood if targeting of CD71 also…”
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Hand Hygiene - Evaluation of Three Disinfectant Hand Sanitizers in a Community Setting: e111969 by Babeluk, Rita, Jutz, Sabrina, Mertlitz, Sarah, Matiasek, Johannes, Klaus, Christoph

“…Hand hygiene is acknowledged as the single most important measure to prevent nosocomial infections in the healthcare setting. Similarly, in non-clinical…”
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