Search Results - "Justin P Rubio"

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28 by Owen, David R, Yeo, Astrid J, Gunn, Roger N, Song, Kijoung, Wadsworth, Graham, Lewis, Andrew, Rhodes, Chris, Pulford, David J, Bennacef, Idriss, Parker, Christine A, StJean, Pamela L, Cardon, Lon R, Mooser, Vincent E, Matthews, Paul M, Rabiner, Eugenii A, Rubio, Justin P

“…[11C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However,…”
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Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination by Chen, Yongfeng, Zhen, Wei, Guo, Tony, Zhao, Yonggang, Liu, Ailian, Rubio, Justin P, Krull, David, Richardson, Jill C, Lu, Hongtao, Wang, Ryan

“…Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple…”
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SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive by Libert, Sergiy, Pointer, Kelli, Bell, Eric L., Das, Abhirup, Cohen, Dena E., Asara, John M., Kapur, Karen, Bergmann, Sven, Preisig, Martin, Otowa, Takeshi, Kendler, Kenneth S., Chen, Xiangning, Hettema, John M., van den Oord, Edwin J., Rubio, Justin P., Guarente, Leonard

“…SIRT1 is a NAD +-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms…”
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Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells by Wilson, Paul A, Santos Franco, Sara, He, Liu, Galwey, Nicholas W, Meakin, Jackie, McIntyre, Rebecca, McHugh, Simon M, Nolan, Michael A, Spain, Sarah L, Carlson, Thaddeus, Lobera, Mercedes, Rubio, Justin P, Davis, Bill, McCarthy, Linda C

“…RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven…”
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Splicing, cis genetic variation and disease by Jensen, Cathy J, Oldfield, Brian J, Rubio, Justin P

“…Splicing is a post-transcriptional modification of RNA during which introns are removed and exons are joined. Most of the mammalian genes undergo constitutive…”
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A conserved sorting-associated protein is mutant in chorea-acanthocytosis by Manfredi, Michela, Malandrini, Alessandro, Rampoldi, Luca, Ferrer, Xavier, Brown, Robert, Rudolf, Gabrielle, Németh, Andrea H, Alonso, Elisa, Vance, Jeffery, Wood, Nicholas W, Carrè, Sophie, Dobson-Stone, Carol, Danek, Adrian, Monaco, Anthony P, Rubio, Justin P, Verellen, Christine, Pericak-Vance, Margaret, Chalmers, Richard M, Fabrizi, Gian M

“…Chorea-acanthocytosis (CHAC, MIM 200150) is an autosomal recessive neurodegenerative disorder characterized by the gradual onset of hyperkinetic movements and…”
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McLeod neuroacanthocytosis: Genotype and phenotype by Danek, Adrian, Rubio, Justin P., Rampoldi, Luca, Ho, Mengfatt, Dobson-Stone, Carol, Tison, François, Symmans, William A., Oechsner, Matthias, Kalckreuth, Wolfgang, Watt, Julie M., Corbett, Alastair J., Hamdalla, Hisham H. M., Marshall, Andrew G., Sutton, Ian, Dotti, Maria Teresa, Malandrini, Alessandro, Walker, Ruth H., Daniels, Geoff, Monaco, Anthony P.

“…McLeod syndrome is caused by mutations of XK, an X‐chromosomal gene of unknown function. Originally defined as a peculiar Kell blood group variant, the disease…”
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Background and Breakthrough Opioid Choice May Determine Different Pain Outcomes by Wong, Aaron K., Vogrin, Sara, Le, Brian, Klepstad, Pal, Rubio, Justin P., Somogyi, Andrew A., Philip, Jennifer

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Opioid Switch Dosing in Chronic Cancer Pain: A Prospective Longitudinal Study by Wong, Aaron K, Klepstad, Pal, Rubio, Justin P, Somogyi, Andrew A, Vogrin, Sara, Le, Brian, Philip, Jennifer

“…Opioid switching is common, however, conversion tables have limitations. Guidelines suggest postswitch dose reduction, yet, observations show opioid doses may…”
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Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci by Patsopoulos, Nikolaos A., de Bakker, Paul I. W.

“…Objective: To perform a 1‐stage meta‐analysis of genome‐wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional…”
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Evidence for the role of FMR1 gray zone alleles as a risk factor for parkinsonism in females by Loesch, Danuta Z., Tassone, Flora, Mellick, George D., Horne, Malcolm, Rubio, Justin P., Bui, Minh Q., Francis, David, Storey, Elsdon

“…ABSTRACT Background and Objective There is convincing evidence that small CGG expansion (41‐54 repeats): FMR1 “gray zone” alleles (GZ) contribute to the risk…”
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Variants of ST8SIA1 are associated with risk of developing multiple sclerosis by Husain, Seema, Yildirim-Toruner, Cagri, Rubio, Justin P, Field, Judith, Schwalb, Marvin, Cook, Stuart, Devoto, Marcella, Vitale, Emilia

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system of unknown etiology with both genetic and environmental factors…”
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Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial by St Jean, Pamela L, Xue, Zhengyu, Carter, Nick, Koh, Gavin C K W, Duparc, Stephan, Taylor, Maxine, Beaumont, Claire, Llanos-Cuentas, Alejandro, Rueangweerayut, Ronnatrai, Krudsood, Srivicha, Green, Justin A, Rubio, Justin P

“…Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria. PQ is the only FDA-approved medicine for…”
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Estimation of the Antirelapse Efficacy of Tafenoquine, Using Plasmodium vivax Genotyping by Beck, Hans-Peter, Wampfler, Rahel, Carter, Nick, Koh, Gavin, Osorio, Lyda, Rueangweerayut, Ronnatrai, Krudsood, Srivcha, Lacerda, Marcus V., Llanos-Cuentas, Alejandro, Duparc, Stephan, Rubio, Justin P., Green, Justin A.

“…Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized,…”
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Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan by Koshy, Beena, Miyashita, Akinori, St Jean, Pamela, Stirnadel, Heide, Kaise, Toshihiko, Rubio, Justin P, Mooser, Vincent, Kuwano, Ryozo, Irizarry, Michael C

“…High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene -…”
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Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells by Paul A Wilson, Sara Santos Franco, Liu He, Nicholas W Galwey, Jackie Meakin, Rebecca McIntyre, Simon M McHugh, Michael A Nolan, Sarah L Spain, Thaddeus Carlson, Mercedes Lobera, Justin P Rubio, Bill Davis, Linda C McCarthy

“…RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven…”
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Evaluation of the effect of UGT1A1 polymorphisms on dolutegravir pharmacokinetics by Chen, Shuguang, St Jean, Pamela, Borland, Julie, Song, Ivy, Yeo, Astrid J, Piscitelli, Stephen, Rubio, Justin P

“…To evaluate potential pharmacogenetic effects of UGT1A1 polymorphisms on the pharmacokinetics (PK) of dolutegravir (Tivicay®; ViiV Healthcare, NC, USA), an…”
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Exome array analysis suggests an increased variant burden in families with schizophrenia by McCarthy, Nina S, Melton, Phillip E, Ward, Sarah V, Allan, Spencer M, Dragovic, Milan, Clark, Melanie L, Morar, Bharti, Rubio, Justin P, Blangero, John, Badcock, Johanna C, Morgan, Vera A, Moses, Eric K, Jablensky, Assen

“…Abstract The exome array assays rare-but-recurrent, likely deleterious, exonic variants and represents an intermediary between single nucleotide polymorphism…”
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Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir by Song, Ivy, Borland, Julie, Chen, Shuguang, Guta, Phyllis, Lou, Yu, Wilfret, David, Wajima, Toshihiro, Savina, Paul, Peppercorn, Amanda, Castellino, Stephen, Wagner, David, Hosking, Louise, Mosteller, Michael, Rubio, Justin P., Piscitelli, Stephen C.

“…Purpose Dolutegravir (DTG) is an unboosted, integrase inhibitor for the treatment of HIV infection. Two studies evaluated the effects of efavirenz (EFV) and…”
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Saliva-Derived DNA Performs Well in Large-Scale, High-Density Single-Nucleotide Polymorphism Microarray Studies by BAHLO, Melanie, STANKOVICH, Jim, DANOY, Patrick, HICKEY, Peter F, TAYLOR, Bruce V, BROWNING, Sharon R, BROWN, Matthew A, RUBIO, Justin P

“…As of June 2009, 361 genome-wide association studies (GWAS) had been referenced by the HuGE database. GWAS require DNA from many thousands of individuals,…”
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