Search Results - "Juss, Jatinder K"

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition by Juss, Jatinder K, House, David, Amour, Augustin, Begg, Malcolm, Herre, Jurgen, Storisteanu, Daniel M L, Hoenderdos, Kim, Bradley, Glyn, Lennon, Mark, Summers, Charlotte, Hessel, Edith M, Condliffe, Alison, Chilvers, Edwin R

“…Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin…”
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Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo by Poole, Emma, Juss, Jatinder K., Krishna, Benjamin, Herre, Jurgen, Chilvers, Edwin R., Sinclair, John

“…Human cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in…”
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Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival by Juss, Jatinder K, Hayhoe, Richard P, Owen, Charles E, Bruce, Ian, Walmsley, Sarah R, Cowburn, Andrew S, Kulkarni, Suhasini, Boyle, Keith B, Stephens, Len, Hawkins, Phillip T, Chilvers, Edwin R, Condliffe, Alison M

“…We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a…”
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Human Cytomegalovirus Delays Neutrophil Apoptosis and Stimulates the Release of a Prosurvival Secretome by Pocock, Joanna M, Storisteanu, Daniel M L, Reeves, Matthew B, Juss, Jatinder K, Wills, Mark R, Cowburn, Andrew S, Chilvers, Edwin R

“…Human cytomegalovirus (HCMV) is a major cause of viral disease in the young and the immune-suppressed. At sites of infection, HCMV recruits the neutrophil, a…”
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Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy by Ismail, Saila, Stokes, Clare A, Prestwich, Elizabeth C, Roberts, Rebecca L, Juss, Jatinder K, Sabroe, Ian, Parker, Lisa C

“…Human rhinoviruses (HRV) are a major cause of exacerbations of airways disease. Aspects of cell signalling responses to HRV infection remain unclear,…”
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Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens by Storisteanu, Daniel M L, Pocock, Joanna M, Cowburn, Andrew S, Juss, Jatinder K, Nadesalingam, Angalee, Nizet, Victor, Chilvers, Edwin R

“…The release of neutrophil extracellular traps (NETs) is a major immune mechanism intended to capture pathogens. These histone- and protease-coated DNA…”
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Hypoxia upregulates neutrophil degranulation and potential for tissue injury by Hoenderdos, Kim, Lodge, Katharine M, Hirst, Robert A, Chen, Cheng, Palazzo, Stefano G C, Emerenciana, Annette, Summers, Charlotte, Angyal, Adri, Porter, Linsey, Juss, Jatinder K, O'Callaghan, Christopher, Chilvers, Edwin R, Condliffe, Alison M

“…The inflamed bronchial mucosal surface is a profoundly hypoxic environment. Neutrophilic airway inflammation and neutrophil-derived proteases have been linked…”
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Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis by Pinder, Emma M, Rostron, Anthony J, Hellyer, Thomas P, Ruchaud-Sparagano, Marie-Helene, Scott, Jonathan, Macfarlane, James G, Wiscombe, Sarah, Widdrington, John D, Roy, Alistair I, Linnett, Vanessa C, Baudouin, Simon V, Wright, Stephen E, Chadwick, Thomas, Fouweather, Tony, Juss, Jatinder K, Chilvers, Edwin R, Bowett, Susan A, Parker, Jennie, McAuley, Daniel F, Conway Morris, Andrew, Simpson, A John

“…Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage…”
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Effects of tocilizumab on neutrophil function and kinetics by Lok, Laurence S. C., Farahi, Neda, Juss, Jatinder K., Loutsios, Chrystalla, Solanki, Chandra K., Peters, Adrien M., Donaldson, Francis, Porter‐Brown, Benjamin, Chilvers, Edwin R.

“…Background Decreases in circulating neutrophils (polymorphonuclear leucocytes, PMNs) have been reported in patients treated with the anti‐interleukin‐6…”
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Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity by Thomas, David C, Clare, Simon, Sowerby, John M, Pardo, Mercedes, Juss, Jatinder K, Goulding, David A, van der Weyden, Louise, Storisteanu, Daniel, Prakash, Ananth, Espéli, Marion, Flint, Shaun, Lee, James C, Hoenderdos, Kim, Kane, Leanne, Harcourt, Katherine, Mukhopadhyay, Subhankar, Umrania, Yagnesh, Antrobus, Robin, Nathan, James A, Adams, David J, Bateman, Alex, Choudhary, Jyoti S, Lyons, Paul A, Condliffe, Alison M, Chilvers, Edwin R, Dougan, Gordon, Smith, Kenneth G C

“…The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising…”
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Neutrophil GM‐CSF receptor dynamics in acute lung injury by Alessandris, Silvia, Ferguson, G. John, Dodd, Alison J., Juss, Jatinder K., Devaprasad, Abhinandan, Piper, Siân, Wyatt, Owen, Killick, Helen, Corkill, Dominic J., Cohen, E. Suzanne, Pandit, Aridaman, Radstake, Timothy R.D.J., Simmonds, Rosalind, Condliffe, Alison M., Sleeman, Matthew A., Cowburn, Andrew S., Finch, Donna K., Chilvers, Edwin R.

“…GM‐CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid…”
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TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils by Radjabova, Valeria, Mastroeni, Piero, Skjødt, Karsten, Zaccone, Paola, de Bono, Bernard, Goodall, Jane C, Chilvers, Edwin R, Juss, Jatinder K, Jones, Des C, Trowsdale, John, Barrow, Alexander David

“…We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T…”
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NBEAL2 is required for neutrophil and NK cell function and pathogen defense by Sowerby, John M, Thomas, David C, Clare, Simon, Espéli, Marion, Guerrero, Jose A, Hoenderdos, Kim, Harcourt, Katherine, Marsden, Morgan, Abdul-Karim, Juneid, Clement, Mathew, Antrobus, Robin, Umrania, Yagnesh, Barton, Philippa R, Flint, Shaun M, Juss, Jatinder K, Condliffe, Alison M, Lyons, Paul A, Humphreys, Ian R, Chilvers, Edwin R, Ouwehand, Willem H, Dougan, Gordon, Smith, Kenneth Gc

“…Mutations in the human NBEAL2 gene cause gray platelet syndrome (GPS), a bleeding diathesis characterized by a lack of α granules in platelets. The functions…”
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Role of Eros, a novel transmembrane protein, in regulation of host defence by Thomas, David C, Dr, Clare, Simon, PhD, Sowerby, John M, PhD, Pardo, Mercedes, PhD, Juss, Jatinder K, MRCP, Goulding, David A, PhD, Van der Weyden, Louise, PhD, Storisteanu, Daniel M L, PhD, Prakash, Ananth, BSc, Espeli, Marion, PhD, Flint, Shaun, MRCP, Lee, James C, MRCP, Hoenderdos, Kim, PhD, Kane, Leanne, BSc, Harcourt, Katherine, BSc, Mukhopadhyay, Subhankar, PhD, Umrania, Yagnesh, PhD, Antrobus, Robin, PhD, Adams, David, PhD, Bateman, Alex, PhD, Choudhary, Jyoti S, PhD, Lyons, Paul A, PhD, Condliffe, Alison M, Prof, Chilvers, Edwin R, Prof, Dougan, Gordon, Prof, Smith, Kenneth G C, Prof

“…Abstract Background Reactive oxygen species (ROS), generated via the phagocyte NADPH oxidase cytochrome b558, are essential for effective immune responses to…”
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Functional capacity of alveolar neutrophils in acute respiratory distress syndrome by Juss, Jatinder K, PhD, Herre, Jurgen, PhD, Amour, Augustin, PhD, Begg, Malcolm, PhD, House, David, PhD, Hessel, Edith M, PhD, Summers, Charlotte, PhD, Condliffe, Alison M, PhD, Chilvers, Edwin R, Prof

“…Abstract Background Inappropriate accumulation or persistence of neutrophils (polymorphonuclear leucocytes [PMNs]), within the alveolar airspace is considered…”
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Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils by Brode, Sven, Farahi, Neda, Cowburn, Andrew S, Juss, Jatinder K, Condliffe, Alison M, Chilvers, Edwin R

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Acupuncture induced pneumothorax – a case report by Juss, Jatinder K, Speed, Catherine A, Warrington, Jayne, Mahadeva, Ravi

“…We report a significant complication of acupuncture in a 50 year old woman who developed a pneumothorax shortly after receiving acupuncture needling to her…”
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Tolterodine-induced hyponatraemia by Juss, Jatinder K., Radhamma, Ajish K. J., Forsyth, Duncan R.

“…Management of electrolyte abnormalities is challenging in older people as the sensation of thirst, renal function and hormonal modulators of the milieu…”
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Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo by Poole, Emma, Juss, Jatinder K, Krishna, Benjamin, Herre, Jurgen, Chilvers, Edwin R, Sinclair, John

“…Human cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in…”
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TARM1 is a novel LRC-encoded ITAM receptor that co-stimulates pro-inflammatory cytokine secretion by macrophages and neutrophils by Radjabova, Valeria, Mastroeni, Piero, Skjødt, Karsten, Zaccone, Paola, de Bono, Bernard, Goodall, Jane C, Chilvers, Edwin R, Juss, Jatinder K, Jones, Des C, Trowsdale, John, Barrow, Alexander David

“…We identified a novel, evolutionarily conserved receptor encoded within the human Leukocyte Receptor Complex (LRC) and syntenic region of mouse chromosome 7,…”
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