Search Results - "Jursic, Branko"

Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides by Backes, Gregory L., Neumann, Donna M., Jursic, Branko S.

“…Efficient synthetic procedures for the preparation of acid hydrazines and hydrazides were developed by converting the corresponding carboxylic acid into the…”
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Preparation of substituted semicarbazides from corresponding amines and hydrazines via phenyl carbamates by Hron, Rebecca, Jursic, Branko S.

“…•Mild reaction conditions for the preparation of substituted semicarbazides.•The preparation method applicable to structurally diverse semicarbazides.•Building…”
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Synthesis and antifungal activity of substituted 2,4,6-pyrimidinetrione carbaldehyde hydrazones by Neumann, Donna M., Cammarata, Amy, Backes, Gregory, Palmer, Glen E., Jursic, Branko S.

“…Opportunistic fungal infections caused by the Candida spp. are the most common human fungal infections, often resulting in severe systemic infections—a…”
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Computational modeling and synthesis of pyridine variants of benzoyl-phenoxy-acetamide with high glioblastoma cytotoxicity and brain tumor penetration by Ingraham, Charles H., Stalinska, Joanna, Carson, Sean C., Colley, Susan B., Rak, Monika, Lassak, Adam, Peruzzi, Francesca, Reiss, Krzysztof, Jursic, Branko S.

“…Glioblastomas are highly aggressive brain tumors for which therapeutic options are very limited. In a quest for new anti-glioblastoma drugs, we focused on…”
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Ligand free open air copper(II) mediated aryl formamidation and amination of aryl halides by Komati, Rajesh, Jursic, Branko S.

“…•Direct foramidation procedure of electron rich aromatic halides was developed.•Aryl amination was performed on open air without copper ligand.•Economical…”
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Exploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential by Stalinska, Joanna, Houser, Lisa, Rak, Monika, Colley, Susan B., Reiss, Krzysztof, Jursic, Branko S.

“…Structural variations of the benzylphenoxyacetamide (BPA) molecular skeleton were explored as a viable starting point for designing new anti-glioblastoma drug…”
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Anti-glioblastoma effects of phenolic variants of benzoylphenoxyacetamide (BPA) with high potential for blood brain barrier penetration by Stalinska, Joanna, Vittori, Cecilia, Ingraham IV, Charles H., Carson, Sean C., Plaisance-Bonstaff, Karlie, Lassak, Adam, Faia, Celeste, Colley, Susan B., Peruzzi, Francesca, Reiss, Krzysztof, Jursic, Branko S.

“…Glioblastomas are the most aggressive brain tumors for which therapeutic options are limited. Current therapies against glioblastoma include surgical…”
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Anticancer potential of aminomethylidene-diazinanes I. Synthesis of arylaminomethylidene of diazinetriones and its cytotoxic effects tested in glioblastoma cells by Pianovich, Nichole A., Dean, Mathew, Lassak, Adam, Reiss, Krzysztof, Jursic, Branko S.

“…[Display omitted] Diazinane and aryl moieties with vinylamine linkers were synthesized to investigate the importance of their structural variations as…”
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Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs by Backes, Gregory L., Jursic, Branko S., Neumann, Donna M.

“…R=5-substituted-2-hydroxyphenyl or pyridinyl. [Display omitted] Schiff base derivatives have recently been shown to possess antimicrobial activity, and these…”
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Synthesis of N-aryl and N-arylcarbamoylamino derivatives of 1,3-diazinane-5-carboxamide and their activity against glioblastoma LN-229 cell line by Hron, Rebecca J., Jursic, Branko S., Neumann, Donna M.

“…[Display omitted] Six structural motifs based on the initial (lead) structure of merbarone were designed, prepared, and tested against the glioblastoma LN-229…”
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Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals by Luna-Tapia, Arturo, Kerns, Morgan E, Eberle, Karen E, Jursic, Branko S, Palmer, Glen E

“…The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the…”
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NMR spectroscopic study of cyclodextrin inclusion complexes with A-007 prodrugs by Sagiraju, Sarada, Jursic, Branko S.

“…One- and two-dimensional NMR spectroscopy was used to demonstrate the formation of inclusion cyclodextrin complexes with several A-007 prodrugs. These…”
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Anticancer activity for 4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and Their abilities to interact with lymphoendothelial cell surface markers by Morgan, Lee Roy, Jursic, Branko S., Hooper, Catherine L., Neumann, Donna M., Thangaraj, Kanappan, LeBlanc, Blaise

“…The structure of the anticancer agent 4,4′-dihydroxybenzophenone-2,4-dinitrophenylhydrazone ( A-007) has been modified through SAR and by incorporating…”
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Antifungal activity of 2α,3β-functionalized steroids stereoselectively increases with the addition of oligosaccharides by Cammarata, Amy, Upadhyay, Sunil Kumar, Jursic, Branko S., Neumann, Donna M.

“…Invasive fungal infections pose a significant problem to the immune-compromised. Moreover, increased resistance to common antifungals requires development of…”
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Microwave-assisted synthesis of 1,3-benzodioxole derivatives from catechol and ketones or aldehydes by Pingali, Subramanya R.K., Jursic, Branko S.

“…An efficient synthetic procedure for the preparation of a diverse library of 1,3-benzodioxoles was developed by applying controlled microwave heating in…”
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Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives by Jursic, Branko S., Upadhyay, Sunil Kumar, Creech, Clinton C., Neumann, Donna M.

“…Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel…”
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Preparation of tagged glucose as a key intermediate in the synthesis of branched oligosaccharides by Upadhyay, Sunil K., Jursic, Branko S.

“…Tagged and activated d-glucose was introduced as a building block for branched oligosaccharides. This building block was the oligosaccharide branching point at…”
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Microwave-Assisted NBS Bromination of p-Iminotoluenes: Preparation of New Alcohol, Mercapto, and Amino Protection Groups by Upadhyay, Sunil K., Jursic, Branko S.

“…A simple, efficient, safe, high-yielding and rapid microwave-assisted method for the preparation of protected p-bromomethyl and p-dibromomethylanilines was…”
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Synthesis and antifungal activity of functionalized 2,3-spirostane isomers by Upadhyay, Sunil Kumar, Creech, Clinton C., Bowdy, Katharine L., Stevens, Edwin D., Jursic, Branko S., Neumann, Donna M.

“…Invasive fungal infections are a major complication for individuals with compromised immune systems. One of the most significant challenges in the treatment of…”
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Electrospray-ionization mass spectrometry study of cyclodextrin complexes with A007 prodrugs by SagiRaju, Sarada, Chen, Kan, Cole, Richard B., Jursic, Branko S.

“…Electrospray-ionization mass spectrometric (ESIMS) studies of several A007 prodrugs in aqueous cyclomaltohexaose (α-cyclodextrin, α-CD), cyclomaltoheptaose…”
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