Search Results - "Jurk, Diana"

Telomere dysfunction in ageing and age-related diseases by Rossiello, Francesca, Jurk, Diana, Passos, João F., d’Adda di Fagagna, Fabrizio

“…Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of…”
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
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A senescent cell bystander effect: senescence‐induced senescence by Nelson, Glyn, Wordsworth, James, Wang, Chunfang, Jurk, Diana, Lawless, Conor, Martin‐Ruiz, Carmen, von Zglinicki, Thomas

“…Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen…”
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Cellular senescence drives age-dependent hepatic steatosis by Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana

“…The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined…”
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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk by Cassidy, Liam D., Young, Andrew R. J., Young, Christopher N. J., Soilleux, Elizabeth J., Fielder, Edward, Weigand, Bettina M., Lagnado, Anthony, Brais, Rebecca, Ktistakis, Nicholas T., Wiggins, Kimberley A., Pyrillou, Katerina, Clarke, Murray C. H., Jurk, Diana, Passos, Joao F., Narita, Masashi

“…Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to…”
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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice by Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.

“…Summary While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long‐term senolytic treatment…”
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Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence by Vizioli, Maria Grazia, Liu, Tianhui, Miller, Karl N, Robertson, Neil A, Gilroy, Kathryn, Lagnado, Anthony B, Perez-Garcia, Arantxa, Kiourtis, Christos, Dasgupta, Nirmalya, Lei, Xue, Kruger, Patrick J, Nixon, Colin, Clark, William, Jurk, Diana, Bird, Thomas G, Passos, João F, Berger, Shelley L, Dou, Zhixun, Adams, Peter D

“…Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable…”
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice by Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana

“…Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a…”
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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline by Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.

“…Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide…”
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Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice by Fielder, Edward, Wan, Tengfei, Alimohammadiha, Ghazaleh, Ishaq, Abbas, Low, Evon, Weigand, B Melanie, Kelly, George, Parker, Craig, Griffin, Brigid, Jurk, Diana, Korolchuk, Viktor I, von Zglinicki, Thomas, Miwa, Satomi

“…Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence…”
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Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response by Jurk, Diana, Wang, Chunfang, Miwa, Satomi, Maddick, Mandy, Korolchuk, Viktor, Tsolou, Avgi, Gonos, Efstathios S., Thrasivoulou, Christopher, Jill Saffrey, M., Cameron, Kerry, von Zglinicki, Thomas

“…Summary In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive…”
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DNA damage response and cellular senescence in tissues of aging mice by Wang, Chunfang, Jurk, Diana, Maddick, Mandy, Nelson, Glyn, Martin‐Ruiz, Carmen, Von Zglinicki, Thomas

“…Summary The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere…”
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Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis by Carroll, Bernadette, Otten, Elsje G., Manni, Diego, Stefanatos, Rhoda, Menzies, Fiona M., Smith, Graham R., Jurk, Diana, Kenneth, Niall, Wilkinson, Simon, Passos, Joao F., Attems, Johannes, Veal, Elizabeth A., Teyssou, Elisa, Seilhean, Danielle, Millecamps, Stéphanie, Eskelinen, Eeva-Liisa, Bronowska, Agnieszka K., Rubinsztein, David C., Sanz, Alberto, Korolchuk, Viktor I.

“…Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic…”
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DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease by Birch, Jodie, Anderson, Rhys K, Correia-Melo, Clara, Jurk, Diana, Hewitt, Graeme, Marques, Francisco Madeira, Green, Nicola J, Moisey, Elizabeth, Birrell, Mark A, Belvisi, Maria G, Black, Fiona, Taylor, John J, Fisher, Andrew J, De Soyza, Anthony, Passos, João F

“…Cellular senescence has been associated with the structural and functional decline observed during physiological lung aging and in chronic obstructive…”
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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis by Farr, Joshua N, Saul, Dominik, Doolittle, Madison L, Kaur, Japneet, Rowsey, Jennifer L, Vos, Stephanie J, Froemming, Mitchell N, Lagnado, Anthony B, Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J, Niedernhofer, Laura J, Robbins, Paul D, Jurk, Diana, Passos, João F, LeBrasseur, Nathan K, Tchkonia, Tamara, Kirkland, James L, Monroe, David G, Khosla, Sundeep

“…Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in…”
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Oxidative stress and life histories: unresolved issues and current needs by Speakman, John R., Blount, Jonathan D., Bronikowski, Anne M., Buffenstein, Rochelle, Isaksson, Caroline, Kirkwood, Tom B. L., Monaghan, Pat, Ozanne, Susan E., Beaulieu, Michaël, Briga, Michael, Carr, Sarah K., Christensen, Louise L., Cochemé, Helena M., Cram, Dominic L., Dantzer, Ben, Harper, Jim M., Jurk, Diana, King, Annette, Noguera, Jose C., Salin, Karine, Sild, Elin, Simons, Mirre J. P., Smith, Shona, Stier, Antoine, Tobler, Michael, Vitikainen, Emma, Peaker, Malcolm, Selman, Colin

“…Life‐history theory concerns the trade‐offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized…”
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Senescence explains age- and obesity-related liver steatosis by Ogrodnik, Mikolaj, Jurk, Diana

“…Cellular senescence, the irreversible loss of replicative potential of somatic cells, was first described in fibroblasts cultured by Leonard Hayflick more than…”
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Characterization of cellular senescence in aging skeletal muscle by Zhang, Xu, Habiballa, Leena, Aversa, Zaira, Ng, Yan Er, Sakamoto, Ayumi E, Englund, Davis A, Pearsall, Vesselina M, White, Thomas A, Robinson, Matthew M, Rivas, Donato A, Dasari, Surendra, Hruby, Adam J, Lagnado, Anthony B, Jachim, Sarah K, Granic, Antoneta, Sayer, Avan A, Jurk, Diana, Lanza, Ian R, Khosla, Sundeep, Fielding, Roger A, Nair, K Sreekumaran, Schafer, Marissa J, Passos, João F, LeBrasseur, Nathan K

“…Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite profound age-associated changes in skeletal muscle (SkM), whether its…”
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Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in primary sclerosing cholangitis by Jalan-Sakrikar, Nidhi, Anwar, Abid, Yaqoob, Usman, Gan, Can, Lagnado, Anthony B., Wixom, Alexander Q., Jurk, Diana, Huebert, Robert C.

“…Cellular senescence and biliary fibrosis are prototypical features of obliterative cholangiopathies, such as Primary Sclerosing Cholangitis (PSC). Telomere…”
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