Search Results - "Jurinke, Christian"

MALDI-TOF mass spectrometry : A versatile tool for high-performance DNA analysis by JURINKE, Christian, OETH, Paul, VAN DEN BOOM, Dirk

“…Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has developed during the past decade into a versatile tool for…”
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The use of MassARRAY technology for high throughput genotyping by Jurinke, Christian, van den Boom, Dirk, Cantor, Charles R, Köster, Hubert

“…This chapter will explore the role of mass spectrometry (MS) as a detection method for genotyping applications and will illustrate how MS evolved from an…”
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A single nucleotide polymorphism based approach for the identification and characterization of gene expression modulation using MassARRAY by Jurinke, Christian, Denissenko, Mikhail F, Oeth, Paul, Ehrich, Matthias, van den Boom, Dirk, Cantor, Charles R

“…Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. Their abundance and the ease with which they can be assayed have lead to…”
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Base-Specific Fragmentation of Amplified 16S rRNA Genes Analyzed by Mass Spectrometry: A Tool for Rapid Bacterial Identification by von Wintzingerode, Friedrich, Böcker, Sebastian, Schötelburg, Cord, Norman H. L. Chiu, Storm, Niels, Jurinke, Christian, Cantor, Charles R., Göbel, Ulf B., van den Boom, Dirk

“…A rapid approach to the 16S rRNA gene (16S rDNA)-based bacterial identification has been developed that combines uracil-DNA-glycosylase (UDG)-mediated…”
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Capture Compounds for the functional isolation of nucleotide interacting proteins by Dülsner, Erik, Jurinke, Christian, Köster, Hubert

“…The innovative Capture Compound mass spectrometry (CCMS) technology allows the functional reduction of biological sample complexity. Small synthetic molecules…”
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Direct detection of synthetic and biologically generated double-stranded DNA by MALDI-TOF MS by Little, Daniel P., Jacob, Anette, Becker, Thomas, Braun, Andreas, Darnhofer-Demar, Brigitte, Jurinke, Christian, van den Boom, Dirk, Köster, Hubert

“…A synthetic 50-mer DNA was mixed at room temperature with a non-complementary or a complementary 27-mer and analyzed by matrix-assisted laser…”
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Automated genotyping using the DNA MassArray technology by Jurinke, Christian, van den Boom, Dirk, Cantor, Charles R, Köster, Hubert

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CCMS technology enables improved proteomic analysis through functional isolation of subproteomes by Dülsner, Erik, Jurinke, Christian, Lenz, Thomas

“…Capture Compound mass spectrometry (CCMS) is a technology to reduce the complexity of biological samples through selective isolation of targeted proteins…”
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Functional isolation of staurosporine binding protein kinases using CCMS technology by Dülsner, Erik, Jurinke, Christian, Fischer, Jenny J, Köster, Hubert

“…Capture Compound mass spectrometry (CCMS) is an innovative technology to reduce biological sample complexity by selective isolation of targeted protein or…”
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RNase T1 mediated base‐specific cleavage and MALDI‐TOF MS for high‐throughput comparative sequence analysis by Hartmer, Ralf, Storm, Niels, Boecker, Sebastian, Rodi, Charles P., Hillenkamp, Franz, Jurinke, Christian, van den Boom, Dirk

“…Here we devise a new method for high‐throughput comparative sequence analysis. The developed protocol comprises a homogeneous in vitro transcription/RNase…”
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Mining Disease Susceptibility Genes through SNP Analyses and Expression Profiling Using MALDI-TOF Mass Spectrometry by Tang, Kai, Oeth, Paul, Kammerer, Stefan, Denissenko, Mikhail F, Ekblom, Jonas, Jurinke, Christian, van den Boom, Dirk, Braun, Andreas, Cantor, Charles R

“…To find genes that underlie disease susceptibilities, genome-wide single nucleotide polymorphisms (SNPs) have been analyzed using high-throughput matrix…”
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MALDI-TOF MS: a platform technology for genetic discovery by Boom, Dirk van den, Beaulieu, Martin, Oeth, Paul, Roth, Rich, Honisch, Christiane, Nelson, Matthew R., Jurinke, Christian, Cantor, Charles

“…Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has been applied as a high-throughput platform technology for…”
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Recovery of Nucleic Acids from Immobilized Biotin−Streptavidin Complexes Using Ammonium Hydroxide and Applications in MALDI-TOF Mass Spectrometry by Jurinke, Christian, van den Boom, Dirk, Collazo, Verena, Lüchow, Anke, Jacob, Anette, Köster, Hubert

“…The effects of ammonium hydroxide treatment of complexes consisting of biotinylated nucleic acids and immobilized streptavidin were investigated. It was found…”
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Analysis of Ligase Chain Reaction Products via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight–Mass Spectrometry by Jurinke, Christian, van den Boom, Dirk, Jacob, Anette, Tang, Kai, Wörl, Ralf, Köster, Hubert

“…A rapid and accurate detection of ligation products generated in ligase chain reactions (LCR) by using matrix-assisted laser desorption/ionization…”
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Asymmetric polymerase chain reaction improves streptavidin-biotin based purification of polymerase chain reaction products prior to matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis by Jurinke, Christian, van den Boom, Dirk, Köster, Hubert

“…Asymmetric polymerase chain reaction (PCR) simplifies the application of biotin–streptavidin based purification formats for PCR products in matrix‐assisted…”
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Microsatellites: perspectives and potentials of mass spectrometric analysis by van den Boom, D, Jurinke, C, McGinniss, M J, Berkenkamp, S

“…Mass spectrometry is a powerful analytical tool in biotechnology. The 'soft' ionization and desorption technologies matrix-assisted laser desorption/ionization…”
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Forward and Reverse DNA Sequencing in a Single Reaction by van den Boom, Dirk, Jurinke, Christian, Ruppert, Andreas, Köster, Hubert

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Combined amplification and sequencing in a single reaction using two DNA polymerases with differential incorporation rates for dideoxynucleotides by van den Boom, Dirk, Ruppert, Andreas, Jurinke, Christian, Köster, Hubert

“…We describe an approach, which combines the process of DNA amplification and sequence determination by using a pair of primers and two DNA polymerases with…”
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Application of nested PCR and mass spectrometry for DNA-based virus detection: HBV-DNA detected in the majority of isolated anti-HBc positive sera by Jurinke, C, Zöllner, B, Feucht, H H, van den Boom, D, Jacob, A, Polywka, S, Laufs, R, Köster, H

“…DNA preparations from three different groups of serum samples were examined for HBV-DNA via a nested polymerase chain reaction assay (lower detection limit: 10…”
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