Search Results - "Jurado, Amalia S"

Mitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventions by Monteiro, João P., Oliveira, Paulo J., Jurado, Amália S.

“…Mitochondria are arbiters in the fragile balance between cell life and death. These organelles present an intricate membrane system, with a peculiar lipid…”
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Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach by Coutinho, Maria Francisca, Santos, Juliana Inês, S Mendonça, Liliana, Matos, Liliana, Prata, Maria João, S Jurado, Amália, Pedroso de Lima, Maria C, Alves, Sandra

“…More than two thirds of Lysosomal Storage Diseases (LSDs) present central nervous system involvement. Nevertheless, only one of the currently approved…”
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MiR-200c-based metabolic modulation in glioblastoma cells as a strategy to overcome tumor chemoresistance by Cardoso, Ana M, Morais, Catarina M, Sousa, Madalena, Rebelo, Olinda, Tão, Hermínio, Barbosa, Marcos, Pedroso de Lima, Maria C, Jurado, Amália S

“…Abstract Glioblastoma (GB) is the most aggressive and common form of primary brain tumor characterized by fast proliferation, high invasion and resistance to…”
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Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression by Cardoso, Ana M, Morais, Catarina M, Cruz, A. Rita, Cardoso, Ana L, Silva, Sandra G, do Vale, M. Luísa, Marques, Eduardo F, Pedroso de Lima, Maria C, Jurado, Amália S

“…Gene delivery targeting mitochondria has the potential to transform the therapeutic landscape of mitochondrial genetic diseases. Taking advantage of the…”
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Stearoyl CoA Desaturase-1 Silencing in Glioblastoma Cells: Phospholipid Remodeling and Cytotoxicity Enhanced upon Autophagy Inhibition by Morais, Catarina M., Cardoso, Ana M., Araújo, Ana Rita D., Reis, Ana, Domingues, Pedro, Domingues, Maria Rosário M., de Lima, Maria C. Pedroso, Jurado, Amália S.

“…Modulation of lipid metabolism is a well-established cancer hallmark, and SCD1 has been recognized as a key enzyme in promoting cancer cell growth, including…”
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Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib by Cardoso, Ana M, Morais, Catarina M, Pena, Frederico, Marante, Tânia, Cunha, Pedro P, Jurado, Amália S, Pedroso de Lima, Maria C

“…Abstract Despite the intense global efforts towards an effective treatment of glioblastoma (GB), current therapeutic options are unsatisfactory with a median…”
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Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through an miR-302a-dependent mechanism by Cardoso, Ana M, Morais, Catarina M, Rebelo, Olinda, Tão, Hermínio, Barbosa, Marcos, Pedroso de Lima, Maria C, Jurado, Amália S

“…Abstract Glioblastoma (GB) is the most frequent and malignant type of brain tumor, for which no effective therapy exists. The high proliferative and invasive…”
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Interaction of fullerene nanoparticles with biomembranes: from the partition in lipid membranes to effects on mitochondrial bioenergetics by Santos, Sandra M, Dinis, Augusto M, Peixoto, Francisco, Ferreira, Lino, Jurado, Amália S, Videira, Romeu A

“…Partition and localization of C60 and its derivative C60(OH)18-22 in lipid membranes and their impact on mitochondrial activity were studied, attempting to…”
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MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy by Cardoso, Ana M S, Sousa, Madalena, Morais, Catarina M, Oancea-Castillo, Liliana R, Régnier-Vigouroux, Anne, Rebelo, Olinda, Tão, Hermínio, Barbosa, Marcos, Pedroso, Maria C de Lima, Jurado, Amália S

“…Glioblastoma (GB) is the most aggressive and common form of primary brain tumor, characterized by fast proliferation, high invasion, and resistance to current…”
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High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors by Cunha, Pedro P, Costa, Pedro M, Morais, Catarina M, Lopes, Inês R, Cardoso, Ana M, Cardoso, Ana L, Mano, Miguel, Jurado, Amália S, Pedroso de Lima, Maria C

“…Glioblastoma (GBM) is a deadly and therapy resistant malignant brain tumour, characterized by an aggressive and diffuse growth pattern, which prevents complete…”
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Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells by Amorim, Ricardo, Simões, Inês C. M, Veloso, Caroline, Carvalho, Adriana, Simões, Rui F, Pereira, Francisco B, Thiel, Theresa, Normann, Andrea, Morais, Catarina, Jurado, Amália S, Wieckowski, Mariusz R, Teixeira, José, Oliveira, Paulo J

“…Non-alcoholic steatohepatitis (NASH), one of the deleterious stages of non-alcoholic fatty liver disease, remains a significant cause of liver-related…”
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Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma by Morais, Catarina M, Cunha, Pedro P, Melo, Tânia, Cardoso, Ana M, Domingues, Pedro, Domingues, M Rosário, Pedroso de Lima, Maria C, Jurado, Amália S

“…A great deal of evidence revealing that lipid metabolism is drastically altered during tumorigenesis has been accumulated. In this work, glucosylceramide…”
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Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics by Silva, Francisco, Paulo, António, Pallier, Agnès, Même, Sandra, Tóth, Éva, Gano, Lurdes, Marques, Fernanda, Geraldes, Carlos F G C, Castro, M Margarida C A, Cardoso, Ana M, Jurado, Amália S, López-Larrubia, Pilar, Lacerda, Sara, Campello, Maria Paula Cabral

“…Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization,…”
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Cell-penetrating peptides as nucleic acid delivery systems: from biophysics to biological applications by Trabulo, Sara, Cardoso, Ana L, Cardoso, Ana M S, Morais, Catarina M, Jurado, Amalia S, Pedroso de Lima, Maria C

“…The increasing knowledge on the genetic basis of disease has allowed the development of promising gene-targeted therapies that can be applied to numerous…”
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Application of Thermoresponsive PNIPAAM‑b‑PAMPTMA Diblock Copolymers in siRNA Delivery by Cardoso, Ana M, Calejo, M. Teresa, Morais, Catarina M, Cardoso, Ana L, Cruz, Rita, Zhu, Kaizheng, Pedroso de Lima, Maria C, Jurado, Amália S, Nyström, Bo

“…Gene knockdown has emerged as an important tool for cancer gene therapy as well as for viral infections and dominantly inherited genetic disorders. The…”
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Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast by Araújo, Ana Rita D, Melo, Tânia, Maciel, Elisabete A, Pereira, Clara, Morais, Catarina M, Santinha, Deolinda R, Tavares, Joana F, Oliveira, Helena, Jurado, Amália S, Costa, Vítor, Domingues, Pedro, Domingues, Maria Rosário M, Santos, Manuel A S

“…The occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10-4 is mostly deleterious to yeast, zebrafish and…”
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Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes by Cruz, Rita Q., Morais, Catarina M., Cardoso, Ana M., Silva, Sandra G., Vale, Maria L., Marques, Eduardo F., Pedroso de Lima, Maria C., Jurado, Amália S.

“…[Display omitted] Glioblastoma (GBM), the highest grade astrocytoma, is one of the most aggressive and challenging cancers to treat. The standard treatment is…”
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New serine-derived gemini surfactants as gene delivery systems by Cardoso, Ana M., Morais, Catarina M., Cruz, A. Rita, Silva, Sandra G., do Vale, M. Luísa, Marques, Eduardo F., de Lima, Maria C. Pedroso, Jurado, Amália S.

“…[Display omitted] •Complexes of serine-derived gemini surfactants efficiently transfect cells.•The most efficient DNA complexes were those containing…”
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Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains by Carvalho, Filipa S., Morais, Catarina M., Holy, Jon, Krasutsky, Dmytro, Yemets, Sergiy V., Krasutsky, Pavel A., Jurado, Amália S., Oliveira, Paulo J., Serafim, Teresa L.

“…Triterpenoids have multiple biological properties, although little information is available regarding their toxicity. The present study evaluates the toxicity…”
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Thermoresponsive hydrogels with low toxicity from mixtures of ethyl(hydroxyethyl) cellulose and arginine-based surfactants by Calejo, Maria Teresa, Kjøniksen, Anna-Lena, Pinazo, Aurora, Pérez, Lourdes, Cardoso, Ana Maria S., Pedroso de Lima, Maria C., Jurado, Amália S., Sande, Sverre Arne, Nyström, Bo

“…Ethyl(hydroxyethyl) cellulose (EHEC) is known to form hydrogels in water at elevated temperatures in the presence of an ionic surfactant. In this paper, the…”
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