Search Results - "Juo, Peter"

Regulation of AMPA receptor trafficking by secreted protein factors by Rennich, Bethany J, Luth, Eric S, Moores, Samantha, Juo, Peter

“…AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain. Regulation of AMPAR levels at synapses controls synaptic strength…”
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The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans by Park, Lidia, Luth, Eric S, Jones, Kelsey, Hofer, Julia, Nguyen, Irene, Watters, Katherine E, Juo, Peter

“…Regulation of AMPA-type glutamate receptor (AMPAR) expression and function alters synaptic strength and is a major mechanism underlying synaptic plasticity…”
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VER/VEGF receptors regulate AMPA receptor surface levels and glutamatergic behavior by Luth, Eric S, Hodul, Molly, Rennich, Bethany J, Riccio, Carmino, Hofer, Julia, Markoja, Kaitlin, Juo, Peter

“…Several intracellular trafficking pathways contribute to the regulation of AMPA receptor (AMPAR) levels at synapses and the control of synaptic strength. While…”
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The Anaphase-Promoting Complex Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans by Juo, Peter, Kaplan, Joshua M.

“…The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that targets key cell cycle regulatory proteins for degradation. Blockade of APC…”
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The scaffolding protein SYD-2/Liprin-α regulates the mobility and polarized distribution of dense-core vesicles in C. elegans motor neurons by Goodwin, Patricia R, Juo, Peter

“…The polarized trafficking of axonal and dendritic components is essential for the development and maintenance of neuronal structure and function…”
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The CaM Kinase CMK-1 Mediates a Negative Feedback Mechanism Coupling the C. elegans Glutamate Receptor GLR-1 with Its Own Transcription by Moss, Benjamin J, Park, Lidia, Dahlberg, Caroline L, Juo, Peter

“…Regulation of synaptic AMPA receptor levels is a major mechanism underlying homeostatic synaptic scaling. While in vitro studies have implicated several…”
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The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases by Kowalski, Jennifer R., Juo, Peter

“…Posttranslational modification of proteins by ubiquitin has emerged as a critical regulator of synapse development and function. Ubiquitination is a reversible…”
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Function of the Deubiquitinating Enzyme USP46 in the Nervous System and Its Regulation by WD40-Repeat Proteins by Hodul, Molly, Dahlberg, Caroline L, Juo, Peter

“…Posttranslational modification of proteins by ubiquitin regulates synapse development and synaptic transmission. Much progress has been made investigating the…”
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TRAIL receptor-2 signals apoptosis through FADD and caspase-8 by Tschopp, Jürg, Bodmer, Jean-Luc, Holler, Nils, Reynard, Séverine, Vinciguerra, Patrizia, Schneider, Pascal, Juo, Peter, Blenis, Joe

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 by Sprick, M R, Weigand, M A, Rieser, E, Rauch, C T, Juo, P, Blenis, J, Krammer, P H, Walczak, H

“…Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various…”
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Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats by Sánchez, Ivelisse, Xu, Chi-Jie, Juo, Peter, Kakizaka, Akira, Blenis, John, Yuan, Junying

“…We show here that caspase-8 is required for the death of primary rat neurons induced by an expanded polyglutamine repeat (Q79). Expression of Q79 recruited and…”
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Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53 by Ding, H F, Lin, Y L, McGill, G, Juo, P, Zhu, H, Blenis, J, Yuan, J, Fisher, D E

“…p53's dual regulation of arrest versus apoptosis may underlie tumor-selective effects of anti-cancer therapy. p53's apoptotic effect has been suggested to…”
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Fas-associated Death Domain Protein (FADD) and Caspase-8 Mediate Up-regulation of c-Fos by Fas Ligand and Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) via a FLICE Inhibitory Protein (FLIP)-regulated Pathway by Siegmund, Daniela, Mauri, Davide, Peters, Nathalie, Juo, Peter, Thome, Margot, Reichwein, Monica, Blenis, John, Scheurich, Peter, Tschopp, Jurg, Wajant, Harald

“…Fas, a death domain-containing member of the tumor necrosis factor receptor family and its ligand FasL have been predominantly studied with respect to their…”
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A Versatile Semester-Long Course-Based Undergraduate Research Experience using Optogenetics and RNAi to Identify Genes Important for Synapse Function by Luth, Eric S, Juo, Peter

“…Compared to traditional teaching laboratory activities, course-based undergraduate research experiences (CUREs) can increase student engagement and confidence,…”
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The p97-UBXN1 complex regulates aggresome formation by Mukkavalli, Sirisha, Klickstein, Jacob Aaron, Ortiz, Betty, Juo, Peter, Raman, Malavika

“…The recognition and disposal of misfolded proteins is essential for the maintenance of cellular homeostasis. Perturbations in the pathways that promote…”
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The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation by Hodul, Molly, Ganji, Rakesh, Dahlberg, Caroline L., Raman, Malavika, Juo, Peter

“…Ubiquitination is a reversible post-translational modification that has emerged as a critical regulator of synapse development and function. However, the…”
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The WD40-repeat Proteins WDR-20 and WDR-48 Bind and Activate the Deubiquitinating Enzyme USP-46 to Promote the Abundance of the Glutamate Receptor GLR-1 in the Ventral Nerve Cord of Caenorhabditis elegans by Dahlberg, Caroline L., Juo, Peter

“…Ubiquitin-mediated endocytosis and degradation of glutamate receptors controls their synaptic abundance and is implicated in modulating synaptic strength. The…”
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A Versatile Semester-Long Course-Based Undergraduate Research Experience using Optogenetics and RNAi to Identify Genes Important for Synapse Function by Luth, Eric S, Juo, Peter

“…Compared to traditional teaching laboratory activities, course-based undergraduate research experiences (CUREs) can increase student engagement and confidence,…”
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Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans by Rennich, Bethany J, Luth, Eric S, Hofer, Julia, Juo, Peter

“…We identified the Low-Density Lipoprotein (LDL) Receptor Related Protein-2 (LRP-2) in a RNAi screen for genes that regulate glutamatergic behavior in …”
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The Scaffolding Protein SYD-2/Liprin-[alpha] Regulates the Mobility and Polarized Distribution of Dense-Core Vesicles in C. elegans Motor Neurons by Goodwin, Patricia R, Juo, Peter

“…The polarized trafficking of axonal and dendritic components is essential for the development and maintenance of neuronal structure and function…”
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