Search Results - "Junwei Hao"

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response by Wan, Dongshan, Jiang, Wei, Hao, Junwei

“…Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential…”
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Linc‐MAF‐4 regulates Th1/Th2 differentiation and is associated with the pathogenesis of multiple sclerosis by targeting MAF by Zhang, Fang, Liu, Guiyou, Wei, Changjuan, Gao, Chao, Hao, Junwei

“…ABSTRACT In this study, we strove to substantiate the ability of linc‐MAF‐4 to act as a regulator of pathogenesis during multiple sclerosis (MS). We recruited…”
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Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke by Zheng, Kai, Lin, Lingmin, Jiang, Wei, Chen, Lin, Zhang, Xiyue, Zhang, Qian, Ren, Yi, Hao, Junwei

“…Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. It has been challenging to define the roles of brain cell subsets…”
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Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke by Li, Qian, Cao, Yuze, Dang, Chun, Han, Bin, Han, Ranran, Ma, Heping, Hao, Junwei, Wang, Lihua

“…Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and sensed by nucleic acid‐sensing pattern recognition receptors. We study…”
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DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway by Zhang, Fang, Liu, Guiyou, Li, Daojing, Wei, Changjuan, Hao, Junwei

“…Inflammation that complicates many autoimmune diseases, such as multiple sclerosis (MS), has been correlated to abnormal differentiation of Th17 cells…”
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages by Han, Ranran, Xiao, Jinting, Zhai, Hui, Hao, Junwei

“…Guillain-Barré syndrome (GBS) is an acute, post-infectious, immune-mediated, demyelinating disease of peripheral nerves and nerve roots. Dimethyl fumarate…”
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The clinical features of combined central and peripheral demyelination and antibodies against the node of Ranvier by Hou, Xiaodan, Liang, Yan, Cui, Pan, Hao, Junwei

“…Background: Combined central and peripheral demyelination (CCPD) is a disease of inflammatory demyelination that affects central and peripheral nerves…”
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Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity by Li, Minshu, Li, Zhiguo, Yao, Yang, Jin, Wei-Na, Wood, Kristofer, Liu, Qiang, Shi, Fu-Dong, Hao, Junwei

“…Astrocytes are believed to bridge interactions between infiltrating lymphocytes and neurons during brain ischemia, but the mechanisms for this action are…”
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Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation by Han, Bin, Jiang, Wei, Cui, Pan, Zheng, Kai, Dang, Chun, Wang, Junjie, Li, He, Chen, Lin, Zhang, Rongxin, Wang, Qing Mei, Ju, Zhenyu, Hao, Junwei

“…Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ…”
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Impact of an immune modulator fingolimod on acute ischemic stroke by Fu, Ying, Zhang, Ningnannan, Ren, Li, Yan, Yaping, Sun, Na, Li, Yu-Jing, Han, Wei, Xue, Rong, Liu, Qiang, Hao, Junwei, Yu, Chunshui, Shi, Fu-Dong

“…Peripheral lymphocytes entering brain ischemic regions orchestrate inflammatory responses, catalyze tissue death, and worsen clinical outcomes of acute…”
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Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation by Yao, Yang, Chen, Li, Xiao, Jinting, Wang, Chunyang, Jiang, Wei, Zhang, Rongxin, Hao, Junwei

“…Inflammation and oxidative stress play an important part in the pathogenesis of focal cerebral ischemia/reperfusion (I/R) injury, resulting in neuronal death…”
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Temperature-related death burden of various neurodegenerative diseases under climate warming: a nationwide modelling study by Yin, Peng, Gao, Ya, Chen, Renjie, Liu, Wei, He, Cheng, Hao, Junwei, Zhou, Maigeng, Kan, Haidong

“…Limited knowledge exists regarding the ramifications of climate warming on death burden from neurodegenerative diseases. Here, we conducted a nationwide,…”
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Remote ischemic conditioning improves cognition in patients with subcortical ischemic vascular dementia by Liao, Zhangyuan, Bu, Yali, Li, Meijie, Han, Ranran, Zhang, Nan, Hao, Junwei, Jiang, Wei

“…Subcortical ischemic vascular dementia (SIVD) is very common among the older people, but has no approved treatment. Preclinical trials show that remote…”
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Upregulation of Microglial ZEB1 Ameliorates Brain Damage after Acute Ischemic Stroke by Li, Daojing, Lang, Wenjing, Zhou, Chen, Wu, Chao, Zhang, Fang, Liu, Qiang, Yang, Shuang, Hao, Junwei

“…Microglia are a key immune-competent cell type that respond to environmental and physiological changes during ischemic stroke. However, the molecular…”
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Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis by Kim, Do Young, Hao, Junwei, Liu, Ruolan, Turner, Gregory, Shi, Fu-Dong, Rho, Jong M

“…A prominent clinical symptom in multiple sclerosis (MS), a progressive disorder of the central nervous system (CNS) due to heightened neuro-inflammation, is…”
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PR‐957, a selective inhibitor of immunoproteasome subunit low‐MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17‐cell differentiation and regulating cytokine production by Liu, Haijie, Wan, Chunxiao, Ding, Yanan, Han, Ranran, He, Yating, Xiao, Jinting, Hao, Junwei

“…Experimental autoimmune neuritis (EAN) is a CD4+ T‐cell–mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system. It has been…”
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Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity by Yin, Jie, Leavenworth, Jianmei W., Li, Yang, Luo, Qi, Xie, Huafeng, Liu, Xinhua, Huang, Shan, Yan, Han, Fu, Zheng, Zhang, Liyun Y., Zhang, Litao, Hao, Junwei, Wu, Xudong, Deng, Xianming, Roberts, Charles W. M., Orkin, Stuart H., Cantor, Harvey, Wang, Xi

“…Changes of histone modification status at critical lineage-specifying gene loci in multipotent precursors can influence cell fate commitment. The contribution…”
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Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages by Jiang, Wei, Li, Daojing, Han, Ranran, Zhang, Chao, Jin, Wei-Na, Wood, Kristofer, Liu, Qiang, Shi, Fu-Dong, Hao, Junwei

“…The nonneural cholinergic system of immune cells is pivotal for the maintenance of immunological homeostasis. Here we demonstrate the expression of choline…”
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Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model by Cui, Pan, Lu, Wanting, Wang, Junjie, Wang, Fei, Zhang, Xiyue, Hou, Xiaodan, Xu, Fang, Liang, Yan, Chai, Guoliang, Hao, Junwei

“…Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely…”
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MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O -GlcNAc Transferase by Liu, Ruiqiong, Ma, Xiaofeng, Chen, Li, Yang, Yang, Zeng, Yi, Gao, Jie, Jiang, Wei, Zhang, Fang, Li, Daojing, Han, Bin, Han, Ranran, Qiu, Rongfang, Huang, Wei, Wang, Yan, Hao, Junwei

“…IL-17-producing Th17 cells have gradually become considered as key factors in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS)…”
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