Histopathological and immunohistochemical analysis of a suspected extraskeletal osteosarcoma in a rabbit ( Oryctolagus cuniculus )

An 8-year-old male rabbit ( ) presented with a subcutaneous mass in the proximal region of the fourth and accessory digit measuring 5.5 x 3.5 x 5.2cm. The mass was non-alopecic and exhibited irregular surface, ulceration and necrosis with predominantly pale and light brown coloring. Radiography reve...

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Bibliographic Details
Published in:	Revista brasileira de medicina veterinária Vol. 46; p. e003324
Main Authors:	de Andrade, Julia Penna, Soares, Camilla Faria, Junqueira, André Luiz de Moura, Santos, Daniel Reis, de Carvalho, Marcelo Pires Nogueira, Nakagaki, Karen Yumi Ribeiro, Viscone, Érica Almeida, Borges, Lize, Cassali, Geovanni Dantas, Horta, Rodrigo Dos Santos
Format:	Journal Article
Language:	English
Published:	Brazil 2024
Subjects:	vimentin pathology immunohistochemistry non-conventional pets oncology osteosarcoma
Online Access:	Get full text
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Summary:	An 8-year-old male rabbit ( ) presented with a subcutaneous mass in the proximal region of the fourth and accessory digit measuring 5.5 x 3.5 x 5.2cm. The mass was non-alopecic and exhibited irregular surface, ulceration and necrosis with predominantly pale and light brown coloring. Radiography revealed no involvement of bone and adjacent periosteum. The mass was marginally resected and the electrochemotherapy (ECT) was performed on the surgical bed. Histopathology and immunohistochemical analysis revealed positive reactions for Vimentin, Runx-2 and ki-67, leading to a diagnosis of extraskeletal osteosarcoma (ESOS). This report described a case of ESOS in a rabbit, thereby delineating its clinical presentation, anatomopathological characteristics, diagnostic modalities and recommended therapeutic interventions.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0100-2430 2527-2179 2527-2179
DOI:	10.29374/2527-2179.bjvm003324