Origin and differentiation of breast nipple syringoma

Origin and differentiation of breast nipple syringoma

Similarities in morphology and in glandular and squamous differentiation patterns amongst syringomas of the breast nipple and of the skin suggest a common nature, but the origin of nipple syringoma remains undefined. Using triple immunofluorescence analysis, we found that cells immunopositive for ba...

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Bibliographic Details
Published in:Scientific reports Vol. 2; no. 1; p. 226
Main Authors: Boecker, Werner, Junkers, Tina, Reusch, Michael, Buerger, Horst, Korsching, Eberhard, Metze, Dieter, Decker, Thomas, Loening, Thomas, Lange, Alina, Samoilova, Vera, Buchwalow, Igor
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 17-01-2012
Nature Publishing Group
Subjects:
631/136/142
631/1647
631/67/2321
692/308
Adult
Aged
Antibodies
Breast
Breast Neoplasms - etiology
Breast Neoplasms - pathology
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - pathology
Cell Differentiation
Cell Lineage
Epithelium
Female
Humanities and Social Sciences
Humans
Immunofluorescence
Keratin
Medical research
Middle Aged
multidisciplinary
Nipples - pathology
Pathology
Research methodology
Science
Skin
Smooth muscle
Syringoma - etiology
Syringoma - pathology
Tumors
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Summary:Similarities in morphology and in glandular and squamous differentiation patterns amongst syringomas of the breast nipple and of the skin suggest a common nature, but the origin of nipple syringoma remains undefined. Using triple immunofluorescence analysis, we found that cells immunopositive for basal keratins K5 and 14 undergo differentiation into glandular and squamous cell lineages. Both tumour types expressed K10, indicative of squamous lineage, but there were specific differences in their glandular lineage. In contrast to the breast nipple syringoma, which expressed glandular keratins K8/18/19, syringoma of the skin only expressed the glandular keratin K19. Therefore, syringomas of the breast nipple and of the skin resemble glandular lineages of the breast nipple duct or eccrine duct epithelium, respectively. From these results we conclude that K5/14-positive cells of the breast nipple ducts are the putative cells of origin for syringomas of the nipple, which highlights the organotypic glandular differentiation potential.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep00226