Search Results - "Junji Yodoi"

Extracellular thioredoxin: A therapeutic tool to combat inflammation by Matsuo, Yoshiyuki, Yodoi, Junji

“…Abstract The manipulation of cellular redox status has emerged as a promising therapeutic strategy to prevent uncontrolled inflammatory response. Thioredoxin…”
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Progress in the mechanism and targeted drug therapy for COPD by Wang, Cuixue, Zhou, Jiedong, Wang, Jinquan, Li, Shujing, Fukunaga, Atsushi, Yodoi, Junji, Tian, Hai

“…Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor airflow. The…”
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Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics by Kasuno, Kenji, Yodoi, Junji, Iwano, Masayuki

“…The development and progression of renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), are the result of heterogeneous…”
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Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2 by Watanabe, Rie, Nakamura, Hajime, Masutani, Hiroshi, Yodoi, Junji

“…Thioredoxin 1 (Trx 1) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- that is ubiquitously present in the human body. Trx 1…”
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Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases by Yoshihara, Eiji, Masaki, So, Matsuo, Yoshiyuki, Chen, Zhe, Tian, Hai, Yodoi, Junji

“…During the past few decades, it has been widely recognized that Reduction-Oxidation (redox) responses occurring at the intra- and extra-cellular levels are one…”
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Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases by Wang, Jinquan, Zhou, Jiedong, Wang, Cuixue, Fukunaga, Atsushi, Li, Shujing, Yodoi, Junji, Tian, Hai

“…Thioredoxin-1 (Trx1) is an important regulator of cellular redox homeostasis that comprises a redox-active dithiol. Trx1 is induced in response to various…”
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Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care by Yodoi, Junji, Matsuo, Yoshiyuki, Tian, Hai, Masutani, Hiroshi, Inamoto, Takashi

“…Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to…”
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Thiol redox barrier; local and systemic surveillance against stress and inflammatory diseases by Yodoi, Junji, Tian, Hai, Masutani, Hiroshi, Nakamura, Hajime

“…A 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, human thioredoxin 1 (TRX) has demonstrated an excellent anti-inflammatory…”
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Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes by Oka, Shin-ichi, Hirata, Tsuyoshi, Suzuki, Wataru, Naito, Daichi, Chen, Yanbin, Chin, Adave, Yaginuma, Hiroaki, Saito, Toshiro, Nagarajan, Narayani, Zhai, Peiyong, Bhat, Santosh, Schesing, Kevin, Shao, Dan, Hirabayashi, Yoko, Yodoi, Junji, Sciarretta, Sebastiano, Sadoshima, Junichi

“…Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps…”
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Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity by Masutani, Hiroshi, Yoshihara, Eiji, Fujimoto, Shimpei, Inagaki, Nobuya, Okawa, Katsuya, Masaki, So, Yodoi, Junji

“…Type 2 diabetes mellitus (T2DM) is characterized by defects in both insulin sensitivity and glucose-stimulated insulin secretion (GSIS) and is often…”
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Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition by Masaki, So, Masutani, Hiroshi, Yoshihara, Eiji, Yodoi, Junji

“…Transforming growth factor beta (TGF-β) has critical roles in regulating cell growth, differentiation, apoptosis, invasion and epithelial-mesenchymal…”
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Redox Regulation in Aging Lungs and Therapeutic Implications of Antioxidants in COPD by Kiyokawa, Hirofumi, Hoshino, Yuma, Sakaguchi, Kazuhiro, Muro, Shigeo, Yodoi, Junji

“…Mammals, including humans, are aerobic organisms with a mature respiratory system to intake oxygen as a vital source of cellular energy. Despite the…”
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Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome by Kaimul, Ahsan M., Nakamura, Hajime, Masutani, Hiroshi, Yodoi, Junji

“…Thioredoxin (TRX), a small redox-active multifunctional protein, acts as a potent antioxidant and a redox regulator in signal transduction. TRX expression is…”
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Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling by Yoshihara, Eiji, Chen, Zhe, Matsuo, Yoshiyuki, Masutani, Hiroshi, Yodoi, Junji

“…The cellular thiol redox state is a crucial mediator of metabolic, signaling and transcriptional processes in cells, and an exquisite balance between the…”
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Redox regulation of cell survival by the thioredoxin superfamily: an implication of redox gene therapy in the heart by Ahsan, Md Kaimul, Lekli, Istvan, Ray, Diptarka, Yodoi, Junji, Das, Dipak K

“…Reactive oxygen species (ROS) are the key mediators of pathogenesis in cardiovascular diseases. Members of the thioredoxin superfamily take an active part in…”
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Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus by Masutani, Hiroshi, Yoshihara, Eiji, Masaki, So, Chen, Zhe, Yodoi, Junji

“…Thioredoxin binding protein -2/ thioredoxin interacting protein is an α-arrestin protein that has attracted much attention as a multifunctional regulator…”
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Thioredoxin-interacting protein suppresses bladder carcinogenesis by Nishizawa, Koji, Nishiyama, Hiroyuki, Matsui, Yoshiyuki, Kobayashi, Takashi, Saito, Ryoichi, Kotani, Hirokazu, Masutani, Hiroshi, Oishi, Shinya, Toda, Yoshinobu, Fujii, Nobutaka, Yodoi, Junji, Ogawa, Osamu

“…Thioredoxin-interacting protein (TXNIP), which has a tumor-suppressive function, is underexpressed in some human cancers. The function of TXNIP in vivo in…”
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Glutaredoxin Exerts an Antiapoptotic Effect by Regulating the Redox State of Akt by Murata, Hiroaki, Ihara, Yoshito, Nakamura, Hajime, Yodoi, Junji, Sumikawa, Koji, Kondo, Takahito

“…Glutaredoxin (GRX) is a small dithiol protein involved in various cellular functions, including the redox regulation of certain enzyme activities. GRX…”
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Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer by Nakamura, Hajime, Masutani, Hiroshi, Yodoi, Junji

“…Thioredoxin-1 (TRX) is a redox-active protein with multiple intracellular and extracellular functions. Intracellular redox balance is maintained by the TRX…”
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Analytical and clinical validation of rapid chemiluminescence enzyme immunoassay for urinary thioredoxin, an oxidative stress-dependent early biomarker of acute kidney injury by Yokoi, Seiji, Kasuno, Kenji, Nishimori, Kazuhisa, Nishikawa, Sho, Nishikawa, Yudai, Morita, Sayu, Kobayashi, Mamiko, Fukushima, Sachiko, Mikami, Daisuke, Takahashi, Naoki, Oota, Yumiko, Kimura, Hideki, Soya, Yoshihiro, Kimata, Shinsuke, Nishimura, Kengo, Ono, Takahiko, Muso, Eri, Yoshida, Haruyoshi, Yodoi, Junji, Iwano, Masayuki

“…•Development of a rapid measuring device for acute renal injury associated with oxidative stress.•Six-minute diagnosis, excellent accuracy, reliability,…”
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